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Biomedical subjects

M Bignotti

Publications and source records attributed to M Bignotti.

8 recordsLinked to original sources
PubMed1996

[Renal and cardiac effects of chronic doxazosin therapy in patients with essential arterial hypertension].

Aim of the study was to evaluate the effects of a 6 month treatment with doxazosin on blood pressure profile, left ventricular morphology and function and microalbuminuria in non diabetics patients with mild to moderate essential hypertension. We selected 12 patient (7 men and 5 women, mean age 47 + 8) with left ventricular (LV) hypertrophy (men LV mass index > 130g/m2, women LV mass index > 110 g/m2) and normal (< 56 mm) LV diastolic diameter at the basal evaluation. Echocardiogram, 24-hour blood pressure monitoring and microalbuminuria have been evaluated after 3 weeks of placebo and 6 months of oral treatment with doxazosin (2 mg once daily). We evaluated: heart rate, 24-hour, day-time and night-time systolic and diastolic blood pressure, LV mass index (LVMi), peak shortening rate (-dD/dt) and peak lengthening rate (+dD/dt) of LV diameter, and systolic wall stress (ESS). At the basal evaluation +dD/dt was reduced (< 3.6 sec-1) in 9 patients; -dD:dt was normal (> 1.9 sec-1) in all. Bun and creatinine was normal before and after treatment. After treatment +dD/dt increased in all patients, with normalization in 7 patient with basal diastolic impairment. ESS and -dD/dt were normal at the basal evaluation and did not change after therapy. The % reduction of LV mass significantly correlated with % decrease of 24-hour (r = 0.71) and day-time systolic BP (r = 0.86) and 24-hour (r = 0.69) and day-time diastolic BP (r = 0.81). In conclusion, treatment with doxazosin is able to induce regression of LV hypertrophy and significantly reduce microalbuminuria.

Albuminuria↗
PubMed1996

[Ambulatory blood pressure monitoring. Clinical use. Is this the right time?].

Despite some technical limits ambulatory blood pressure monitoring must be considered as a careful instrument for blood pressure measurement. After demonstration of its sensibility and specificity in experimental trials, the use of blood pressure monitoring has been extended to clinical evaluation. The recent Consensus Conferences on Ambulatory blood pressure monitoring has suggested that this method should not be routinely yet, but it should be recommended in clinical selected cases.

Blood Pressure Monitoring, Ambulatory↗
PubMed1995

Ambulatory blood pressure and left ventricular changes during antihypertensive treatment: perindopril versus isradipine.

Using digitized M-mode echocardiograms and 24-h ambulatory blood pressure (BP) monitoring, we compared the effects on left ventricle (LV) and BP of 6-month treatment with a calcium antagonist or an angiotensin-converting enzyme (ACE) inhibitor in 36 hypertensive patients with LV hypertrophy (group 1, 18 subjects treated with sustained-release isradipine; group 2, 18 subjects treated with perindopril). At the basal evaluation, the two groups had comparable BP and LV parameters. After treatment, both groups showed a similar and significant reduction in 24-h, day- and night-systolic and diastolic BP (SBP, DBP). The reduction in LV mass index was greater (p < 0.01) in group 2. In group 1, percentage of decrease of LV mass correlated significantly with percentage of decrease in 24-h and daytime BP; this was not true of group 2. Together with the reduction in LV hypertrophy, there was a significant increase of peak lengthening rate of LV diameter that was greater (p < 0.01) in group 1. Both drugs can reduce LV hypertrophy and improve diastolic function. The reduction of hypertrophy induced by perindopril appears to be partly independent of BP decrease and therefore partly related to a direct action of perindopril on the myocardium.

Adult↗
PubMed1995

One-year antihypertensive treatment with amlodipine: effects on 24-hour blood pressure and left ventricular anatomy and function.

Using digitized M-mode echocardiograms and 24-hour noninvasive ambulatory blood pressure monitoring, we evaluated the effects of 1 year treatment with amlodipine on left ventricular morphology and function in 10 hypertensives with left ventricular hypertrophy. Echocardiograms and 24-hour blood pressure monitoring were performed after 3 weeks of wash-out and after 1 year of oral treatment with amlodipine (5 mg once daily). The therapy significantly lowered blood pressure, without changes in heart rate. Left ventricular mass decreased in all the patients and peak lengthening rate of left ventricular diameter, index of diastolic function, increased in all, with normalization in 5 of the 6 with basal diastolic impairment. Peak shortening rate of left ventricular diameter, index of systolic function, was normal in all at the basal evaluation and did not change after therapy. The percentage reduction of left ventricular mass index significantly correlated with percentage decrease of 24-hour and day-time systolic and diastolic blood pressure. Amlodipine is able to induce regression of left ventricular diastolic function and no changes of systolic function.

Adult↗
PubMed1993

Effects of sustained-release isradipine on left ventricular anatomy and function in systemic hypertension.

With use of digitized M-mode echocardiograms and 24-hour noninvasive ambulatory blood pressure (BP) monitoring, the effects of chronic treatment with sustained-release isradipine on left ventricular (LV) morphology and function in hypertensive patients were evaluated. We selected 12 patients with LV hypertrophy and normal LV diastolic diameter. Echocardiograms and 24-hour BP monitoring were performed after 2 weeks of placebo and after 6 months of oral treatment with sustained-release isradipine (5 mg once daily). Therapy significantly reduced BP without changes in heart rate. LV mass decreased in all patients and peak lengthening rate of LV diameter, index of diastolic function, increased in all, with normalization in 7 of the 9 with basal diastolic impairment. Peak shortening rate of LV diameter, index of systolic function, was normal in all patients at basal evaluation and did not change after therapy. Reduction in LV mass significantly (p < 0.05) correlated with the decrease in average 24-hour and daytime systolic and diastolic BP. Sustained-release isradipine administered once daily is an effective antihypertensive agent; the drug also induces regression of LV hypertrophy, with significant improvement in LV diastolic function and no deterioration in systolic function.

Adult↗
PubMedDate not supplied

Clinical feasibility of echocardiographic automated border detection in monitoring left ventricular response to acute changes of preload in normal subjects.

Echocardiographic automated border detection (ABD) provides an instantaneous measurement of left ventricular (LV) volume and its rate of change. We tested the clinical feasibility of ABD in monitoring on-line LV response to acute changes in preload. We examined 20 healthy males in the supine position, with legs elevated, back in the supine position, 5 min after the inflation of blood pressure cuffs at the root of the four limbs, 5 min after the deflation of cuffs. End-diastolic and end-systolic LV volumes significantly increased with elevated legs and decreased during cuff inflation; ejection fraction remained unchanged. Peak filling and peak emptying rates did not change with elevated legs and increased significantly during cuff inflation. The values of LV parameters were stable in the three resting conditions, demonstrating a good reproducibility of the ABD technique. Our results demonstrate that ABD may be useful in clinical practice for monitoring on-line small acute changes in LV volume and function.

Adult↗