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Biomedical subjects

M Bindoni

Publications and source records attributed to M Bindoni.

At least 37 records · Page 2Linked to original sources
PubMed1984

Physiological and pathological influences of central nervous system on the immune system: a critical appraisal.

There is considerable evidence of intricate links between central nervous and immune systems. This paper makes a critical assessment of these relationships. Recent experimental data on hypothalamic influences on Natural Killer activity in mice have been presented and the problems met with in defining causal nexuses discussed. Some information on immune reactivity in patients with mental disorders has briefly been reviewed.

Animals↗
PubMed1980

Growth of Yoshida ascites tumor in the rat after radiofrequency destruction of the tuberoinfundibular region of the hypothalamus.

The mitotic index of Yoshida ascites tumor cells was significantly higher in rats that underwent tuberoinfundibular destruction than those lesioned in other regions of the hypothalamus or in the cerebral hemispheres or in sham-operated animals. Survival was shorter in the rats lesioned in the tubero-infundibular and posterior hypothalamic regions. The rise in the mitotic index of Yoshida ascites tumor cells is consistent with the results of previous work showing significantly increased cell proliferation in the normal tissues of animals lesioned in the tuberoinfundibular region.

Acoustic Stimulation↗
PubMed1977

[Mitotic activity in the glandular epithelium of the rat small intestine after electrothermocoagulation of the tubero-infundibular region of the hypothalamus and simultaneous resection of the pineal gland].

Radio-frequency lesions of the tubero-infundibular region of the hypothalamus and simultaneous pinealectomy are performed in rats. The double operation is followed by a significant increase of mitotic rate in the small intestine glandular epithelium. This increase is higher than the addition of the effects that are caused by each operation.

Animals↗
PubMed1977

[The effects of lesions in several zones of the brain on cell multiplication in the glandular epithelium of the rat small intestine].

Radio-frequency lesions of tubero-infundibular region of the hypothalamus are followed by a significant increase of the mitotic rate in the small intestine glandular epithelium in rats. This increase does not occur when radio-frequency lesions are located in the anterior and posterior hypothalamus, in the dorsomedial thalamus and in the cerebral hemispheres.

Animals↗
PubMed1976

Characterization and partial purification of a substance in the pineal gland which inhibits cell multiplication in vitro.

A substance which inhibits the in vitro multiplication of 3 cell strains, 37 RC, KB and NCTC clone 929, was characterized in the sheep pineal gland and partially purified using three successive chromatography techniques, respectively on Sephadex G-25, CM-cellulose and Biogel P 60 columns. The sheep cerebral cortex and liver also contain, but at much lower concentration than in the pineal, substance(s) that behave in different tests like the factor isolated from the pineal. The nature of the antimitotic substance from the pineal is as yet unknown. It is not destroyed by treatment with proteolytic enzymes, nor by boiling with 6 M HC1. It was established that it is different from the known antiblastic drugs such as Daunomycin and Methotrexate and from some active substances known to be present in the pineal, such as melatonin, secotonin and norepinephrine, which, in the same conditions, did not show any antimitotic activity. It was shown that when the concentration of the pineal factor in the culture medium was high enough (10 mug/ml), the inhibition of the KB cells multiplication was complete and irreversible. Microscopic examination of the treated cells showed that the morphological alteration was rapid (3--6 h) and deep, with shrinkage of both cytoplasm and nucleus, while with antiblastic drugs, morphological alteration proceeded slower (1--3 days) and appeared less pronounced.

Animals↗