[Pathography, mysterious disease and death of Alexander the Great (historical and medical hypothesis)].
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Biomedical subjects
Publications and source records attributed to M Bizjak.
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A new home-made electronic spirometer (Vitalomer 1) is presented. The adequacy of measurement of lung volumes and flows with Vitalomer is assessed in two ways: by registration of volume changes after filling the device by air from the syringe of known volume and by so called "biological testing". By this method in the group of healthy subjects and patients with airflow obstruction the volumes and flows were simultaneously measured both by Vitalomer and standard spirometer (Vitalograph). The values, measured by both devices, were compared according to two statistical methods. Analysis has showed that Vitalomer is comparable in measurement of volumes and flows with well-known Vitalograph and that it fulfils the criteria proposed for spirometers by American Thoracic Society (ATS) and Communauté Européenne du Charbon et de l'Acier (CECA). The handling with new device is very simple as well as its cleaning. Vitalomer is therefore appropriate for diagnostic spirometry both in out-patients clinics as well as in hospital wards.
The technical characteristics of most frequently used devices for the production of aerosol have been described together with their effect on deposition of aerosol in tracheobronchial system. However, there are many reasons to prefer jet nebulisers for everyday application.
The author is resuming part of the reports and discussions from the 26th Golnik symposium with the main topic "The measurement of nonspecific bronchial responsiveness." The indications for nonspecific bronhcoprovocation tests, different methods for production of aerosol and ways of inhalation of bronchoconstrictory agent are discussed. Further on the procedures for measurement of bronchial response, shorter one by inhalation of one dose and longer one by increased quantities of metacholine or histamine together with the interpretation of the results have been introduced as well.
The measurement of transfer factor of the lung with CO rebreathing method (TLcoRB) is presented by slightly modified method of Clark et al. The measurements were performed in 32 healthy subjects and in 24 patients with restrictive or obstructive ventilatory defect and compared with the values of TLcoSB. TLcoRB was in all examined persons cca 30% lower than TLcoSB. Contrary to that Kco in healthy subjects was the same in both methods while the values of KcoRB in patients were slightly lower than KcoSB. It is concluded that measurement of TLco rebreathing method is suitable for routine use. The measurement of TLcoRB may be performed also in patients with severely decreased ventilatory capacity and even at patient's bed. In specialised laboratories for lung function test TLcoRB should be used as parallel method in routine work.
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