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M Bizot

Publications and source records attributed to M Bizot.

17 recordsLinked to original sources
PubMed2002

JAHK: a low frequency antigen associated with the rG complex of the Rh blood group system.

We have investigated a 'new' low frequency antigen JAHK, which is a marker for the rare Rh gene complex rG. The rG haplotype does not produce any D, c or E antigens, but does produce a strong G antigen. The rG haplotype [d(C)(e)G] is associated with weak C and weak e antigens. Three unrelated rG/dce individuals and one rG/rG propositus were JAHK+. In addition, three propositi whose red cells had a typical expression of C and/or e antigen, which could not be shown to be rG because of a normal D antigen produced by the haplotype in trans, were also JAHK+. Families of three of the propositi demonstrate the inheritance of JAHK as a Mendelian dominant character. It is likely that the JAHK antigen results from conformational changes in an RhCcEe protein that has the amino acid characteristic of c antigen at position 16 and the amino acid residues characteristic of C antigen at positions 60, 68, and 103. JAHK has been assigned the number RH53.

Blood Grouping and Crossmatching↗
PubMed1983

[The importance of HLA typing in cases of disputed paternity].

In dispute paternity, the biologists must reply to two questions: 1. Is the paternity excluded or possible? 2. If it is possible, what is its probability? Valid answers can be given, using several genetic markers, among which HLA genes are specially interesting. Looking at HLA-A, B, C, DR typing of child, mother and presumed father, we propose a method which allows a direct calculation of paternity probability. Crossing over between HLA genes in presumed father and in mother are also considered in this method. In our experience, adding the date provided by the HLA genes and other genetic markers, we obtained, either formal exclusions, or possible paternities with a probability almost always higher than 90%.

Female↗
PubMed1982

[Phenotyping Kell and Duffy antigens by a technic of coagglutination on the Groupamatic G 360].

By adapting the technique of coagglutination to the Groupamatic, we have developed an efficient rapid method of phenotyping donors for the Kell and Fya antigens. 340 specimens can be tested per hour; 800 tests can be performed with only 15 ml of antisera. Over 10,000 donor specimens were tested for Kell and 2,470 were simultaneously phenotyped for Fya. No false negatives were observed. The rate, of false positive results, due to autoagglutinins coating the donors' red cells, was the same as that seen with the continuous flow method. We conclude that this technique is suitable for routine use in screening donors for Kell and Fya antigens.

Autoanalysis↗
PubMed1980

[Detection and identification of irregular anti-erythrocyte antibodies with the Groupamatic G 360. Adaptation to the routine].

The screening of irregular red-cell antibodies on 20.200 recipient samples was carried out simultaneously on continuous flux AUTO-ANALYZER (LIP-bromeline) and GROUPAMATIC (TPC-bromeline). From results it appears: --an equivalent sensibility of both technologies to detect Rh, Kell, Duffy and Kidd antibodies; --a higher sensibility of Groupamatic to detect particularly Lewis and P1 antibodies; --a clear superiority of TPC compared to bromeline technique which is commonly used with Groupamatic. Small modifications of the standard TPC system allow to associate, in routine work, detection of irregular red-cell antibodies with other analyses, such as ABO Rh grouping and phenotyping. From this last point of view, a restricted test of coagglutination phenotyping has revealed to be very promising.

Antibodies↗
PubMedDate not supplied

[Cad antigens].

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Absorption↗