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Acetaldehyde, the first metabolite of ethyl alcohol, is found in higher concentrations in alcoholics and heavy drinkers after alcohol ingestion than in social drinkers or abstainers. This experiment investigated gender differences related to acetaldehyde. Seventy-nine adult social drinkers (38 females and 41 males) were tested after an overnight fast and at least 4 hours food deprived with 0.52 g/kg ethanol in water (20% alcohol by volume). Blood alcohol and acetaldehyde concentrations from breath samples were determined every 5 minutes post-drink for 40 minutes with a gas chromatograph. The drink was consumed over a 5-minute period. Half of each group ran 30-140 miles per week. The other half were controls. A significant overall gender difference in peak acetaldehyde concentration was obtained (p less than 0.5), with males showing higher values than females. Among athletes, these gender differences were greater (p less than 0.002). Among controls the gender differences were in the same direction but they were not significant. Groups did not differ reliably on age (M = 32.88 years, F = 31.13 years), drinking history (M = 2.07, F = 1.92) or lean body mass (M = 43.1, F = 43.1). Groups did not differ on time to peak blood alcohol concentrations (M = 30.98 min, F = 31.58 min). The results have implications for gender differences in alcoholism and biological sensitivity to alcohol.