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Biomedical subjects

M Blasini

Publications and source records attributed to M Blasini.

11 recordsLinked to original sources
PubMed1991

Transscleral Nd:YAG laser cyclophotocoagulation with a contact lens.

Transscleral Nd:YAG laser cyclophotocoagulation was performed on 100 consecutive patients. A contact lens designed specifically for this operation was used, and the results were compared to those of a previously reported series of 100 patients in which the same procedure was performed without the lens. The lens provided intraoperative advantages of eyelid separation, compression and blanching of the conjunctiva at the treatment site, and precise measurements for placement of the laser applications. Early postoperative advantages were reduced conjunctival burns and less hyperemia. However, the long-term results were comparable between the two series, with the exception of a higher incidence of phthisis when the lens was used. The thinning and blanching of the conjunctiva may increase the percentage of laser energy reaching the ciliary processes, which suggests a need for reduced energy levels when using the lens.

Adult↗
PubMed1991

A comparison of total and partial tenonectomy with trabeculectomy.

We compared the results of two methods of tenonectomy at the time of trabeculectomy. Of 49 eyes, 23 were randomly assigned to a partial tenonectomy and 26 to a total tenonectomy. There was no statistically significant difference in the success rate between the two surgical groups using an upper limit of intraocular pressure of either 18 or 21 mm Hg as the criterion for success. There was no difference in the need for postoperative medications or further surgical intervention between the two groups. Although certain advantages exist with each technique, these findings suggest that equivalent results can be anticipated with either a total or partial tenonectomy.

Female↗
PubMed1991

Early postoperative prognostic indicators following trabeculectomy.

We compared prognostic indicators manifesting within the first 2 postoperative days, with filtration status 3 months following trabeculectomy in 51 primary open-angle glaucoma patients. Patients with an avascular area in the filtering bleb 2 days after surgery had a significantly lower (P less than .05) intraocular pressure (IOP) (12.6 mm Hg) 3 months postoperatively than patients with vascular blebs (16.3 mm Hg). However, neither the height, breadth, or transparency of the filtering bleb, presence of microcysts, anterior chamber depth, nor IOP during the first 2 postoperative days were related significantly to the filtration status at 3 months.

Female↗
PubMed1990

Comparison of transscleral neodymium:YAG cyclophotocoagulation with and without a contact lens in human autopsy eyes.

A contact lens designed to facilitate neodymium:YAG transscleral cyclophotocoagulation was evaluated on human autopsy eyes, and the lesions produced were compared to the lesions produced by similar laser treatments without a lens. Using the thermal mode at 20-msec duration, the variables studied were distance from the corneoscleral limbus (0.5, 1.5, 2.5 mm); energy (2, 4, 6, 8 J); and offset (distance between the focal points of the aiming and therapeutic beams; settings of 5, 7, 8, 9). By gross and light microscopic inspection, the ciliary body lesions produced were similar with or without the lens. A distance between 0.5 and 1.5 mm appears optimal for damaging the pars plicata. Energies of 4 to 8 J produced ciliary epithelial destruction.

Ciliary Body↗
PubMed1990

Evaluation of a protocol for transscleral neodymium: YAG cyclophotocoagulation in one hundred patients.

One hundred consecutive patients with intractable glaucoma underwent transscleral neodymium: YAG (Nd:YAG) cyclophotocoagulation using a standard protocol derived from a study of human autopsy eyes, and were followed prospectively for a minimum of 6 months. After the first treatment, 51 patients had a final intraocular pressure (IOP) between 7 and 20 mmHg (classified as "IOP success") and 17 more had an IOP less than 7 mmHg or more than 20 mmHg, but required no additional surgery ("qualified IOP success"). With one or more additional treatments, the totals rose to 65 IOP successes and 30 qualified IOP successes. Parameters associated with qualified success and failure were younger age and higher preoperative IOP. Forty-five patients in the cumulative IOP success and qualified IOP success groups had reduced visual acuity, although this could be attributed to other ocular problems in at least one half of the cases. Other postoperative complications included transient IOP rise in 23 patients, severe pain in 12 patients, and severe inflammation in 29 patients.

Adolescent↗
PubMed1990

Early tissue response to transscleral neodymium: YAG cyclophotocoagulation.

Transscleral cyclophotocoagulation was performed with a neodymium: YAG laser on five patients 24-72 hr before enucleation for a blind, painful eye. The thermal mode at 20 ms and a maximum offset between aiming and therapeutic beams were kept constant. Variable parameters evaluated were energy levels between 2 and 8 J and distance from the limbus of 0.5-3.0 mm. Because of the underlying distortion in three of the eyes, meaningful interpretation by light microscopic evaluation was possible only in the other two. This suggested that the early histologic hallmark of the procedure is similar to that previously observed in human autopsy eyes with ciliary epithelial damage and elevation from underlying tissue. In addition, fibrin and scant inflammatory cells were seen in the space between ciliary epithelium and stroma. Minimal damage was observed in the ciliary muscle. These findings suggest that direct damage to the ciliary epithelium is the most likely mechanism of reduced aqueous production by this cyclodestructive procedure. The findings also support the concept that an anterior placement of approximately 1.0-1.5 mm posterior to the limbus is most likely to damage the ciliary epithelium of the pars plicata.

Ciliary Body↗
PubMed1989

Splenic cyst: a case report.

The following presentation deals with a case report of a large true splenic cyst. After a thorough research of the available medical literature this appears to be the largest reported specimen of this entity.

Adult↗
PubMedDate not supplied

Adverse drugs reactions associated with glaucoma medications.

We undertook a non-concurrent prospective study of 191 Puerto Rican patients from August 1993 to April 1994. All patients had open angle glaucoma (OAG) (age ranged from 50 to 80 yrs; mean = 65 yrs). Patient's symptomatology associated to side effects of their glaucoma medicadons was reviewed. Incidence percent of ocular and/or systemic side effects per medication were: levobunolol 45.0%; betaxolol 42.0%; timolol 27.3%; pilocarpine 100%; dipivefrin 14.0%; and acetazolamide 250 mg 64.1%. Incidence percent of ocular and/or systemic side effects of topical beta-blockers used with concomittant medications were determined. Ocular side effects were more frequent in patients using levobunolol 44.2% than in those patients using betaxolol 42.0%, 8.5% of patients using levobunolol did report systemic side effects. No systemic side effects were reported by patients using betaxolol. Ocular side effects in patients using pilocarpine were frequent (100%); whereas the frequency of systemic side effects was low (6.1%). Systemic side effects were common in patients using carbonic anhydrase inhibitors. These results suggest that non-selective and cardio-selective topical Beta-blockers, differ in their ocular or systemic side effects.

Acetazolamide↗