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Biomedical subjects

M Block

Publications and source records attributed to M Block.

At least 163 records · Page 9Linked to original sources
PubMed1981

Treatment of stage D prostatic carcinoma with megestrol acetate.

Nine previously untreated patients with stage D prostatic carcinoma received megestrol acetate 40 mg orally three times daily. Responses included five partial regressions, two stabilizations, and two progressions. Duration of response ranged from 3+ to 33+ months, with a mean of 11.7 months and a median of 12 months. Three of five patients who had failed prior hormonal therapy remained objectively stable while receiving megestrol acetate. No gastrointestinal toxicity, gynecomastia, fluid retention, or thromboembolic complications were observed during treatment. Weight gain of 5 to 51 pounds occurred in seven of 14 patients.

Aged↗
PubMed1981

Satisfaction and distress in a community: a test of the effects of life events.

A household survey of 537 residents was conducted to test conflicting hypotheses about the correlates of life events derived from three general models of well-being: an equilibrium, a life crisis, and a positive mental health model. Consistent with the predictions of a positive mental health approach, positive life events were correlated with both reports of distress and satisfaction. Further, positive and negative events were intercorrelated; the distress effects of positive events could be accounted for to a large extent by the negative events associated with them. The findings suggest that community studies need to assess the potentially positive as well as stressful effects of life events.

Adolescent↗
PubMed1981

The pathogenesis of infantile malignant osteopetrosis: bone mineral metabolism and complications in five infants.

Bone mineral metabolism was studied in five infants aged 8 to 22 months with severe osteopetrosis. There were findings consistent with biochemical osteomalacia. These included hypocalcemia, hypophosphatemia, high serum acid phosphatase and alkaline phosphatase activity, high levels of serum parathyroid hormone, and high urinary cyclic AMP. Serum 1,25(OH)2 vitamin D3 level was high in the one patient tested. Radiographs in all infants revealed rachitic changes in the metaphyses. However, dense bones on radiographs, calcium balance studies, and radio-calcium absorption studies demonstrated markedly positive calcium balance. Iliac crest bone biopsies showed increased quantity of woven bone with abundant numbers of osteoclasts, excessive amounts of osteoid, myelofibrosis, and a decreased number of Howship's lacunae. The wide bands of unmineralized osteoid did not take up tetracycline. In vitro bone resorbing activity due to osteoclast activating factor from cultured stimulated leukocytes was normal. Bone turnover however, was now as evidenced by low urinary hydroxyproline levels. We interpret these findings as indicating there is decreased bone remodeling and resorption in spite of increased humoral stimuli and osteoclasts. Since calcitonin levels were normal for age, the most likely cause of the impaired bone remodeling sequence was defective osteoclast function. We postulate that there may be a common genetic defect in phagocyte cells, including monocytes, neutrophils and osteoclasts, which accounts for the abnormalities of mineral metabolism and previously reported hematologic, neurologic, and infectious complications.

Biopsy, Needle↗
PubMed1980

Clinical evaluation of three free-thyroxine assays.

The free thyroxine (FT4) test of Clinical Assays, Corning Medical, and Damon Diagnostics were evaluated in 245 patients. Although all three assays generally correlated well with the clinical functional status, there were apparent discrepancies in the clinically euthyroid population. All patients with discordant values had either relatively high or low triiodothyronine (T3) uptakes. In these instances, the free-thyroxine index gave a more accurate assessment of the clinical thyroid status than did the FT4. In our opinion, these findings place a critical limitation on these assays as a replacement for the free-thyroxine index.

Evaluation Studies as Topic↗
PubMed1979

Life stress and maladaptation of children.

Social environmental variables differentiating maladapting children from matched controls in four inner-city elementary schools were investigated. Teacher selection was used to identify the maladapting children. Identified maladapting children were more likely to have been on welfare and to have experienced significantly more stressful life events during the previous year than the matched control children. The maladapting group was subdivided into welfare and non-welfare groups. Comparisons between groups on the life stress event measures indicated that the nonwelfare maladapting group experienced more life events than either the nonwelfare controls or the maladapting welfare children. The measures of life events correlated with parent ratings of behavior problems for the nonwelfare maladapting group but not for the welfare maladapting or the control groups.

Adaptation, Psychological↗
PubMed1979

Osteomalacic new bone formation during chemotherapy of acute granulocytic leukemia.

The development of a rapid rate of regeneration of osteomalacic bone in a patient treated for acute granulocytic leukemia has been demonstrated for the first time. This positive bone balance was most intense at the time of maximal depletion of leukemic tissue. The authors postulate that new formation of osteomalcic bone is due to inability to maintain the rate of calcification parallel to that of bone formation. A similar abnormality occurs in egg-laying birds, in rapidly growing children on a diet suboptimal in vitamin D who have rickets, and in some patients with osteoblastic metastases.

Bone Marrow↗
PubMed1978

Triiodothyronine uptake test in which antibody-coated tubes are used compared to two other tests in which precipitation separations are used.

A triiodothyronine uptake test in which antibody-coated tubes are used (Clinical Assays) was compared to two other such tests in which silicate tablets (Nuclear-Medical Laboratories, Inc.) or macroaggregated albumin (Diagnostic Corporation of America) are used to separate the bound from the free fraction. The Clinical Assays test showed good linear correlation with the values obtained by the other two tests on 67 samples. The interassay coefficient of variation was 4.8%. The correlation between the values obtained and the clinical evaluation on 60 patients also was essentially the same as for the other two tests, 80%.

Antibodies↗
PubMed1975

Clinical implications of lactose-positive breast secretions in nonpuerperal females.

Inappropriate milk-like secretion from the breasts is not infrequently encountered in patients. Usually these secretions have been identified as milk on the basis of their characteristic appearance, and only rarely has their identity as milk been proven by appropriate analysis. Since milk is chemically defined as a lactose-containing mammary secretion, the presence of lactose in a breast secretion identifies it as milk irrespective of its appearance or the presence of other constituents. Lactose can be readily identified by thin-layer chromatographic methods, which despite their inherent speed and sensitivity have not been widely utilized. A method using commercially prepared cellulose layers and a sandwich developing apparatus is presented in detail. This method utilizes current advances in chromatographic techniques and permits rapid and accurate identification of lactose in breast secretions. Such secretions from 10 nonpuerperal women were screened for the presence of lactose. The milk-like secretions from 8 contained varying amounts of lactose, which was not detectable in the secretions from the other 2. There was no correlation between the appearance of the secretion and the presence of lactose.

Breast↗