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Biomedical subjects

M Boga

Publications and source records attributed to M Boga.

17 recordsLinked to original sources
PubMed2005

The combined effect of iloprost and N-acetylcysteine in preventing spinal cord ischemia in rabbits.

OBJECTIVES: This study investigated the cytoprotective effects of N-acetylcysteine (NAC) and iloprost on spinal cord ischemia in an experimental model. MATERIALS AND METHODS: Thirty-five (male) New Zealand white rabbits were included in five study groups (n=7, each group). One group served as Sham. Rabbits in other groups had their abdominal aorta cross-clamped just above the iliac bifurcation for 40 min. During aortic cross clamping, iloprost, NAC, both iloprost and NAC or saline (control) were infused. RESULTS: In NAC, iloprost, and iloprost+NAC groups, neurological status of rabbits (Tarlov score) 24 and 48 h after the operation was better than the control group (p<0.01), but worse than the Sham group (p<0.01). There was minimal neuronal damage in the iloprost treated groups compared to the NAC group (p<0.05). Mean viability index values in NAC, iloprost and iloprost+NAC groups were higher than the control group (p<0.01). Viability index in the NAC group was lower than the iloprost and iloprost+NAC groups. CONCLUSIONS: The use of iloprost and NAC may provide better protection from spinal cord ischemia.

Acetylcysteine↗
PubMed2001

Effectiveness of endothelial cell seeding on patency of damaged vascular surfaces in a canine model.

The effects of endothelial cell seeding, which is assumed to be an effective technique to improve patency rates of denuded vascular surfaces, were investigated in an experimental model. In this study, after anesthetic induction, jugular veins of 16 dogs were harvested bilaterally. Endothelial cells were extracted enzymatically by collagenase from these veins and were passaged into a culture medium until they grew to a reasonable number. After 3 weeks, dogs were anesthetized again in a similar fashion and bilateral femoral veins were exposed and experimental intimal denudation was performed. Subsequently, one femoral artery was injected with cell solution and the other with saline solution as a control. Two weeks after the injections, arteriographic studies of femoral arteries were performed and arterial specimens were taken for histological evaluation. Our results suggest that endothelial seeding might improve the patency rate in elective but urgent cases in which endarterectomy, percutaneous transluminal angioplasty, or similar vascular procedures are considered.

Animals↗
PubMed2000

Comparative analysis of left ventricular hemodynamics and hypertrophy after aortic valve replacement with homografts or mechanical valves.

BACKGROUND AND AIM OF THE STUDY: The study aim was to examine comparatively the effects of prosthetic and homograft valves in the aortic position on ventricular hemodynamics and structure. METHODS: Hemodynamic evaluations were performed at rest and during exercise in 38 patients who had undergone aortic valve replacement (AVR) with either a homograft (n = 19) or prosthetic valve (19-23 mm; n = 19). Using echocardiographic, electrocardiographic and hematologic methods, the pressure gradient (PG); aortic valve area; diameters of left anterior wall, posterior wall (PW) and interventricular septum (IVS); ejection fraction (EF); left ventricular mass (LVM) and mass index (LVMI); electrocardiographic data of LV hypertrophy; hemoglobin; hematocrit and lactate dehydrogenase (LDH) levels were measured. RESULTS: LVM and LVMI decreased significantly after surgery in both groups (p<0.001), but the decrease was significantly greater in the homograft group (p<0.05). The IVS and PW diameters in the homograft group decreased significantly postoperatively (p<0.05); the inter-group difference was also significant (p<0.01). In the homograft group there was a significant improvement in EF (p<0.05), and the exercise PG was significantly less. Both groups showed improved LV hypertrophy and correlation between V1S >24 mm criteria and LVMI measurements. Postoperative LDH levels in the homograft group were significantly lower than preoperative levels (p<0.05); the intergroup difference was also significant (p<0.001). CONCLUSIONS: Our data suggest that homografts, as compared to mechanical prostheses, provide significantly better hemodynamics in the aortic position.

Adult↗
PubMedDate not supplied

[The role of several simultaneously acting mechanisms in the formation of the clinical symptomatology of Goodpasture's syndrome].

Two cases of Goodpasture syndrome in young patients are described; the importance of a detailed analysis of the symptoms is stressed and found useful in explaining the origin of simultaneous manifestations of allergic reactions of different mechanisms. Thus a wider variety of therapeutical possibilities may be applied and better allowance made for the nature of diseases. An analogy is assumed between the occurrence of the symptoms described and of the development of auto-immune diseases which have not, or only with difficulty, been differentiated.

Adolescent↗
PubMedDate not supplied

[Infectious and neoplastic complications in rheumatoid arthritis].

Three cases are reported of rheumatic arthritis protracted over several decades, with reduced immunobiological resistance, who developed infectious arthritis, a syndrome with urticaria and angio-edematous signs and increased monoclonal IgM synthesis, and Hodgkin's disease. The discussion covers the manifold pathogenesis, the common and simultaneous effect of constitutional, local factors of the development of the disease, related to the generally reduced resistance of the organism, and the therapeutical moments (corticosteroids, immunosuppressives); further the establishment of therapeutical measures in the interest of the prevention of the complications mentioned.

Aged↗