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Biomedical subjects

M Bogdanov

Publications and source records attributed to M Bogdanov.

32 records · Page 2Linked to original sources
PubMed1978

[Cyclophosphamide content in the meat and milk after a single application to sheep].

Investigated were two groups of 10 Merino sheep each. The test group were given orally cyclophosphamide, singly, at the rate of 25 mg/kg, while the controls of the second group were not treated but were kept under the same conditions. Both milk and meat of the two groups were investigated by thin layer chromatography and gas chromatography on the 1st, 4th, 9th, 14th, 23rd, and 30th day following the introduction of cyclophosphamide. The results obtained by gas chromatography showed that it was not until the fourth day that there were two metabolites of the compound in milk only. On the 9th day the same were established in the milk and meat samples in a maximum concentration, the excretion from the body of the treated animals starting as early as the 14th day. By the 23rd day there were traces only, and after the 30th they were no longer established. Thin-layer chromatography showed that the two metabolites were found in approximately equal amounts up to the 14th day following treatment, and were fully excreted after the third week. Therefore, the full elimination of cyclophosphamide metabolites from the milk and meat of sheep treated with it at the rate cited takes place in about four weeks.

Animals↗
PubMed1977

[Studies of the etiology of infectious abortion in cows in Ruse District].

A total of 28,159 blood serum samples have been examined for brucellosis, 87--for leptospirosis, 84--for toxoplasmosis, 554--for the presence of rickettsii and neoreckettsii, and 193--for total protein content, albumin, and protein fractions, taken from cows in the course of the years on 40 dairy farms in the district of Rousse. Bacteriologically were examined 349 aborted fetuses, 178 samples of estral secretion, 57 placentae, and 1002 samples of washings and seminal fluid from bulls for vibriosis. Bacteriologic investigations were also carried out on 383 fetuses for salmonellosis, listeriosis, and colibacteriosis, and virologic studies of 398 placentae and parenchymal organs of fetuses. Twenty-eight fetuses were studied parasitologically for toxoplasmosis, and 118 blood smears were examined for hemosporidiosis. It was established that most important in the etiology of the infectious abortions in cows in the district of Rousse were Vibrio organisms. They were found in 36.9 per cent of the studied bovine fetuses and in 24.4 per cent of all materials examined bacteriologically. Only 4 cases were noted of neorickettsii from fetuses and placentae. Serologically, there were 23.6 per cent cases positive for neorickettsiosis, and 12.6 per cent--for Q fever; 56.4 per cent of the investigated sera proved positive for leptospirosis. In 0.8 per cent of the examined fetuses there was Escherichia coli. Abortions in cows were also due to anaplasmosis and francaillelosis; 14.2 per cent of the investigated respective sera were positive for toxoplasmosis. On the days of abortions the amount of total protein was 7.13 mg%, that of albumins--36%, and of globulins--64%. It is considered imperative to elucidate the cause of abortions of infectious nature in cows in connection with the establishing of cattle-breeding complexes.

Abortion, Veterinary↗
PubMed1977

[Chemical and hematologic studies of sheep before and after treatment with cyclophosphamide].

Studied was the effect of cyclophosphamide, a typical venena A agent, on 15 sheep and 20 weaned lambs, given orally at 25 mg/kg. A total of 13 types of laboratory investigations were carried out revealing a dependable increase in the calcium and phosphorus levels with young animals, and a dependable decrease in the gamma-2-globulin with adult animals. At the individual application of the preparation the fleece was removed manually on the eleventh day in all animals. At the group application of a granulated formula the fleece in some animals was removed hardly on the 11th-15th day, and with one sheep and 3 weaned lambs shearing was effected mechanically.

Animals↗
PubMed1976

[Effect of betaine hydrochloride on broiler chickens when used alone or in combination with vitamin B12].

The studies were carried out with 2287 broilers aged from 3 to 56 days, divided when one-day-old into four equal groups. The first group were fed the common ration and served as controls. The remaining three groups were experimental, the broilers of the second group being offered the basic common ration enriched with 0.2 per cent betaine. The third group were also given the ordinary ration, however, they received in the drinking water some 10 mug vitamin BUI per one kilogram feed each. The fourth group received both betaine and vitamin B12 at the rates indicated. Results showed that betaine hydrochloride offered either alone or in combination with vitamin B12 contributes to increasing the liveweight gain of broilers in the course of the starter period, but its use in doses of 0.2 per cent in the finishing period is not effective.

Animal Nutritional Physiological Phenomena↗