PubMed Health⌕ Search

Biomedical subjects

M Bogićević

Publications and source records attributed to M Bogićević.

14 recordsLinked to original sources
PubMed1996

[Functional and morphologic study of kidneys using radioisotope methods].

This survey of investigation of renal function and morphology by radionuclides. Radiopharmaceuticals with different pathways of renal excretion or fixation, and methods of their use are presented. These methods assess separate kidney function, as well as blood and urine flow by a noninvasive way.

Humans↗
PubMed1993

Thyroid hormone profiles in experimental acute renal failure.

Thyroid hormone profiles were determined in two groups of dogs made uremic, either by i.v. uranyl nitrate 10 mg/kg BW injection or by bilateral ureteral ligation, and in one group of sham-operated animals. Each group consisted of 6 dogs and served as its own control. From blood samples taken in 12-h intervals up to 144 h for uranyl nitrate-injected dogs and 96 h for operated dogs, serum levels of T4, T3, fT4, fT3, rT3, and cortisol were measured by radioimmunoassays. The results obtained in both groups of uremic dogs showed an initial sharp fall of T4, T3, fT4, and fT3 followed by a plateau or retarded decrease. In sham-operated dogs the fall of these hormones was slight and of short duration. Reverse T3 had a tendency to increase in all groups examined, but a significant elevation was recorded only after bilateral ureteral ligation. In this group cortisol serum levels were found the highest, being also significantly increased in the other two groups. The temporal coincidence of the most marked alterations in T3, rT3, and cortisol serum concentrations indicates a significant role of stress in thyroid dysfunction. Although serum creatinine rise and weight loss were not parallel with thyroid hormone alterations, the involvement of uremic compounds and malnutrition in this process is also quite clear. Thus, the data presented suggest simultaneous influences of uremic toxins, stress, and malnutrition on the induction of thyroid dysfunction in dogs made uremic by uranyl nitrate injection or bilateral ureteral ligation.(ABSTRACT TRUNCATED AT 250 WORDS)

Acute Kidney Injury↗
PubMed1993

Myoglobin elimination in end stage kidney disease patients on renal replacement treatment.

Increased serum myoglobin levels were previously found in patients with chronic renal failure. In this report we have studied the effects of dialysis on myoglobin elimination in patients on CAPD, IPD, cuprophan and polyacrylonitrile (PAN) membrane hemodialysis. Peritoneal dialysis removed a significant amount of myoglobin, CAPD 480 +/- 65 micrograms/day, IPD 270 +/- 25 micrograms/12 h treatment, while with cuprophan dialysis none, and with PAN dialysis only an insignificant amount of myoglobin. The serum myoglobin levels were 250 +/- 18 and 264 +/- 14 micrograms/l on cuprophan and a 3 month dialysis on PAN membrane, respectively. Markedly increased serum levels were also found in CAPD and IPD patients on peritoneal dialysis, 227 +/- 25 and 286 +/- 32 micrograms/l respectively. This study has shown that there is an increased serum myoglobin concentration in end-stage kidney disease patients on dialysis. Although peritoneal membrane is permeable to myoglobin, a relatively small amount is removed, and the serum level in CAPD and IPD patients was not significantly different from the serum myoglobin concentration in hemodialysis patients. Furthermore myoglobin could not be removed by hemodialysis membrane and an analysis of its important extrarenal catabolism level points were analyzed.

Acrylic Resins↗
PubMed1990

[The effect of thyroxine on renal function in experimental acute renal insufficiency].

The aim of the study was to investigate the influence of exogenous thyroxine upon the kidney function in the experimental renal failure induced by the uranyl acetate application. Acute renal failure was induced by uranyl acetate in 32 rats, divided into 4 groups, each consisted of 8 rats. The group of untreated animals and the group of animals treated with thyroxine only were used as controls. Then glomerular filtration rate was determined in all the rats taken in the experiment. The comparison was made between the control or the group with acute renal failure without the thyroxine treatment and the groups treated with a single application of thyroxine before, simultaneously and after the uranyl acetate injection. An improvement of the glomerural filtration rate and a decrease of the blood nitrogen retention were obtained in rats with acute renal failure pretreated with thyroxine. Necrotic alterations of the kidney cortex were less marked in this group than in the group without thyroxine treatment. The improvements of the kidney function and morphology in acute renal failure suggest the possibility of the protective effect of thyroxine.

Acute Kidney Injury↗
PubMed1988

Relationship between parathyroid hormone and pituitary-testicular axis in patients on maintenance hemodialysis.

The effect of secondary hyperparathyroidism upon hormones of the pituitary testicular axis was studied in 39 end-stage kidney disease male patients on maintenance hemodialysis. In hemodialysed patients the mean serum levels of PTH, prolactin and LH were significantly increased, that of testosterone decreased, and of FSH unchanged. PTH and prolactin values were found to be dependent upon residual renal function measured by 24 h urine output. A significant positive correlation was found between the serum levels of PTH and LH (r = 0.405) and between PTH and serum levels of prolactin (r = 0.401). Secondary hyperparathyroidism is suggested to be responsible, at least partly, for sexual dysfunction in male patients on maintenance hemodialysis.

Adolescent↗
PubMedDate not supplied

[Diurnal changes in the levels of immunoreactive parathyroid hormone and calcitonin in patients with chronic renal insufficiency].

The circadian rhythms of the serum immunoreactive parathyroid hormone (iPTH) and calcitonin concentration were examined in 6 patients with chronic renal failure (CRF) not treated by haemodialysis. In 3 patients on haemodialysis the influence of haemodialysis with cuprophan and polyacrylonitrile membranes (in a.m. and p.m. periods of day) on serum concentration of these was investigated. The results demonstrate that in patients with CRF in predialysis period the circadian rhythm of serum iPTH concentration is at least partially preserved. However, the effect of dialysis on serum C-terminal iPTH concentration showed a sharp progressive fall of the concentration during haemodialysis on polyacrylonitrile membranes. The study of the circadian rhythm of serum calcitonin concentration in CRF patients with the six hours intervals between blood sampling could not reveal changes which favour the opinion of the existence of circadian rhythmicity. In patients on haemodialysis during haemodialysis with cuprophan membranes a rise of serum calcitonin concentration was observed.

Adult↗
PubMedDate not supplied

[Serum myoglobin levels in patients with acute and chronic renal insufficiency].

The serum level of myoglobin was studied in 20 patients with acute renal failure, in 16 chronic renal failure patients and in 94 patients on maintenance haemodialysis. The serum myoglobin level was significantly increased in the oligoanuric phase of acute renal failure, rapidly decreased during diuretic phase and attained apparently normal values in the recovery phase. In patients with chronic renal failure the serum myoglobin level correlated with serum creatinine and creatinine clearance as a measure of the glomerular filtration rate, indicating a major role of kidney in the metabolism of this low-molecular weight protein. It was established that myoglobin could not be removed by dialysis membrane and analysis of the myoglobin level in endstage kidney disease patients on maintenance hemodialysis has shown an important extrarenal catabolism of this protein.

Acute Kidney Injury↗
PubMedDate not supplied

[Fixation of tubules with radioactive technetium dimercaptosuccinate in parenchymal diseases of the kidney].

In order to evaluate tubular function 99mTc-DMS dynamic kidney scintigraphy and 99mTc-DMS uptake determinations were performed in 55 patients with endemic nephropathy, diabetic nephropathy and glomerulo nephritis. From 64-656th segment of computerized radiorenograms 99mTc-DMS uptake and curve slope were assessed and compared with the corresponding parameters of 20 healthy subjects. Both parameters were decreased in patients of all three groups. Tubular uptake of 99mTc-DMS measured during 60 sec. 4 hours after 99mTc-DMS administration, was decreased in endemic nephropathy and diabetic nephropathy, but without a significant difference in glomerulonephritic patients. The study of the relationship between 4 hour 99mTc-DMS tubular fixation and glomerular filtration rate, estimated by 99mTc-DTPA clearance, showed a positive correlation only in patients with diabetic nephropathy. Patients with renal failure from all three groups had more seriously impaired tubular handling of 99mTc-DMS, that correlated with reduction of the glomerular filtration rate. The present data showed more severe impairment of tubular function in patients with endemic nephropathy and diabetic nephropathy than in glomerulonephritic patients. The method was suitable for estimation of the tubular function.

Balkan Nephropathy↗