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Biomedical subjects

M Bojsen-Moller

Publications and source records attributed to M Bojsen-Moller.

4 recordsLinked to original sources

Radiation-induced meningeal sarcoma. A case report with a review of the literature.

A case is reported of a 21 month old boy from whom a 357 g ependymona was removed. Postoperatively, radiation therapy (Co60) was administered, and the central dosage was estimated to be 4,350 r given over 46 days. Seven and a half years later craniotomy was again performed because of a supposed recurrence. However, a meningeal sarcoma weighing 370 g was found. Tumour induction by radiotherapy is discussed on the basis of published reports, and the need of estimating tumour dose in relationship to the age of the patient is stressed.

Age Factors↗

Polyvinylpyrrolidone-storage disease. Light microscopical, ultrastructural and chemical verification.

The light and electron microscopical findings in the polyvinylpyrrolidine-storage disease are reported on the basis of biopsies of skin, striated muscle, bone marrow and liver from one patient and a subcutaneous nodule from another patient. Both patients suffer from diabetes insipidus and have been treated for several years with Insipidin retard, which contains polyvinylpyrrolidone (PVP) as the retarding agent. Deposits of PVP have been demonstrated in all the tissues examined and can easily be recognized by certain staining qualities. The combination of haematoxylin-eosin, elastin (Weigert), alkaline Congo red and Sirius red for amyloid and PTAH is specially to be recommended. The ultrastructural findings consist of intracellular vacuoles containing a granular material and probably representing lysosomes. The final identification of the nature of the deposits has been made by spectrophotometric analysis. The suspicion of a case of PVP-storage disease should result in a skin biopsy which usually is sufficient for the diagnosis.

Bone Marrow↗

[Masks and men].

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