Biomedical subjects
Publications and source records attributed to M Bommen.
Neonatal septicaemia and meningitis remain major causes of mortality and of neurodevelopmental sequelae, especially in premature and low birthweight babies: early diagnosis with appropriate antimicrobial and supportive treatment is essential to minimize the risk of complications. Congenital viral and protozoal infections also require diagnosis in the neonatal period so that long-term surveillance and management for complications can be planned.
17 boys with delayed growth spurt, 9 of whom also had late puberty, were treated with 2.5 to 5.0 mg of fluoxymesterone daily for 0.23-0.58 years. Mean increment of growth velocity was 4.5 cm/year during treatment and this was maintained at 3.8 cm/year over a post-treatment observation period of 0.22-1.3 years. Mean testicular volume at the end of the treatment period was 9.9 ml. Mean height for bone age standard deviation score remained unchanged at -1.2 to -1.4 (not significant). We conclude that a low dose of fluoxymesterone may be used in safety for a short time to induce a growth acceleration in adolescent boys with constitutional delay of growth and puberty.
A five-day-old premature infant presented with hyperbilirubinemia, vomiting, and an abdominal mass. At laparotomy a gastric duplication cyst was removed from the pyloric region.
We describe two children with hypoglycaemia due to pancreatic beta cell hyperactivity. Both had low serum insulin but raised plasma C peptide concentrations when hypoglycaemic. Measurement of C peptide is valuable in the diagnosis of hyperinsulinaemic hypoglycaemia in children.
A 13-year-old boy who maintains his body temperature between 33 and 35 degrees C was investigated. Tests of peripheral and central thermoregulatory function did not show a specific abnormality, except for some generalised hypothalamic dysfunction of unknown aetiology. He responded appropriated when his temperature was altered from its usual low level. His temperature regulatory mechanisms appeared to be set at a temperature lower than is normal.
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