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Biomedical subjects

M Boni

Publications and source records attributed to M Boni.

At least 55 records · Page 3Linked to original sources
PubMed1982

[Surgical treatment of cervical arthrosis. Follow-up review (2-13 years) of the 1st 100 cases operated on by anterior approach].

The authors have dissected 137 cadavers and have noted the frequency of degenerative lesions of the intervertebral disc and articular facets. Calcified protrusions were more frequent than uncalcified ones. During the same period, 100 patients were operated on, 72 of whom suffered from root involvement and 28 from root and cord involvement. The Cloward technique was used at one or two levels in 90 cases and partial resection of the vertebral bodies when more than two levels were involved in 10 cases. The technique of bone resection and grafting is described in detail. Few complications were noted, all of which regressed. There was one post-operative death. Fusion was obtained in all cases. In 22 cases a post-operative kyphosis was noted. 87 patients had a true improvement in their neurological status.

Adult↗
PubMed1980

Surgical treatment of traumatic lesions of the middle and lower cervical spine (C3-C7).

The writers report on the treatment of traumatic lesions of the middle and lower cervical spine (sprains, fractures, fracture dislocations). The techniques and surgical routes most commonly used and reported in the literature are discussed. After a brief review of a comparable group of twenty-two patients followed up from two to ten years after operation, the authors present their views on the prognosis and some considerations arising out of their experience.

Adolescent↗
PubMed1979

Biochemical and structural abnormalities of the connective tissue in Larsen's syndrome.

Skin, iliac crest cartilage and tendon of a patient affected with Larsen's syndrome were subjected to biochemical and ultrastructural investigation. A substantial increase in the ratio of glucosamine to galactosamine was found both in skin and cartilage. Ultrastructural abnormalities of collagen fibres and proteoglycan filaments were also found in Larsen's tissues. The significance of these findings are discussed.

Cartilage↗
PubMed1977

Osteogenesis imperfecta: morphological, histochemical and biochemical aspects. Modifications induced by (+)-catechin.

Two patients affected with two different forms of Osteogenesis Imperfecta were examined in order to study collagen and glycosaminoglycans (GAGs) in skin and iliac crest cartilage. A sharp decrease of the galactosamine to glucosamine ratio due to a reduced content of chondroitin sulfate was evidenced in both patients. Moreover the structure of proteoglycans appeared altered, this being more evident in the severe form of the disease. Morphological examination in light and electron microscopy of cartilage of the less severely diseased patient showed that GAGs in the extracellular matrix did not present regular connection with collagen fibers. Chondrocytes, elongated and disorderly scattered, showed large lipidic inclusions and, on histochemical basis, were devoid of UDPG dehydrogenase activity. Treatment with (+)-catechin produced an improvement, in both patients, of the biochemical pattern of collagen and GAGs. Similarly a shift of the cellular activity and of the matrix morphology towards normality was observed in the investigated cartilage of the less severely affected patient.

Adolescent↗
PubMed1977

Experimental arthrosis from intra-articular vitamin A injection in the rabbit. Morphological and biochemical study: considerations on the pathogenesis of human arthrosis in relation to the experimental model.

The key to the pathogenesis of arthrosis lies in the mechanism responsible for the initial lesions. In this experimental work the possibility of producing arthrosic changes is demonstrated by activating lysosomal chondrocytic enzymes by the intra-articular injection of Vitamin A in rabbits. On the basis of the experimental results the authors discuss the possible role that activation of the lysosomal hydrolytic enzymes might play in producing primary and secondary arthrosis in humans. They advance the hypothesis that this mechanism may be the common final step in the degradation of the articular cartilage, whatever the aetiological factor.

Acid Phosphatase↗
PubMed1976

Fractures in haemophilia.

Eight cases of fractures in haemophiliac patients are presented. The clinical and radiological features, behaviour and response to treatment indicate that they are normal, not pathological fractures. If fractures in haemophiliac patients are treated early and correctly both from a haematological and orthopaedic point of view, the results are comparable with those in normal subjects. The haematological and orthopaedic management is discussed.

Adolescent↗