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M Boniuk

Publications and source records attributed to M Boniuk.

At least 19 recordsLinked to original sources
PubMed2000

Melanocytoma (magnocellular nevus) of the ciliary body: report of 10 cases and review of the literature.

PURPOSE: To describe the characteristics of melanocytoma (magnocellular nevus) of the ciliary body, an unusual melanocytic tumor. DESIGN: Retrospective, clinicopathologic case series. METHODS: Ten melanocytomas of the ciliary body were examined histopathologically. Five tumors were also examined by transmission electron microscopy. The clinical histories were abstracted from the patients' medical records. We compared the clinical, histopathologic, and ultrastructural findings of our 10 cases with those previously reported in the literature. MAIN OUTCOME MEASURES: To define clinical and histopathologic parameters of this rare tumor. RESULTS: A total of 40 cases were summarized, including our 10 and 30 previously reported cases. The mean age of the 40 cases was 47 years. Twenty-six patients were female (65%), fourteen were male (35%). No laterality was observed. Eighty percent of the patients were white and 10% were black. The most common clinical presentation was an asymptomatic dark spot involving the iris and ciliary body or the sclera. Involvement of chamber angle structures, with or without intrascleral extension, was observed in 85% (34 of 40 patients); but only 12% (2 of the 17 patients for whom information about intraocular pressure and local extension was available) had elevated preoperative intraocular pressure. By electron microscopy, two distinct cell types were observed. CONCLUSIONS: Melanocytomas can usually be distinguished from other pigmented lesions of the ciliary body by histopathologic criteria, but may be difficult to differentiate before surgery from other pigmented ciliary body tumors, including malignant melanomas, adenomas, and adenocarcinomas of the pigmented ciliary epithelium. Most tumors can be managed conservatively by iridocyclectomy.

Adult↗
PubMed2000

Vibrio ocular infections on the U.S. Gulf Coast.

PURPOSE: To describe the epidemiology of Vibrio eye infections. METHOD: We reviewed the records of a patient from our institution with V. vulnificus keratitis and conducted a literature search for other cases of ocular infections with Vibrio species. RESULTS: A 39-year-old fisherman was struck in his left eye with an oyster shell fragment, developed suppurative V. vulnificus keratitis, and was successfully treated with combined cefazolin and gentamicin. Including our patient, 17 cases of eye infections with Vibrio spp. have been reported, and 11 (65%) involved exposure to seawater or shellfish. Of the seven cases due to V. vulnificus (six keratitis and one endophthalmitis), six had known exposure to shellfish or seawater along the U.S. coast of the Gulf of Mexico. Of five cases of V. alginolyticus conjunctivitis, three had been exposed to fish or shellfish. Three infections with V. parahaemolyticus (one keratitis and two endophthalmitis) were reported; two of these occurred in people exposed to brackish water on or near the Gulf Coast. Two cases of postsurgical endophthalmitis, one with V. albensis and one with V. fluvialis, also were reported. CONCLUSIONS: In addition to septicemia, gastroenteritis, and wound infections, halophilic noncholera Vibrio species can cause sight-threatening ocular infections. Ocular trauma by shellfish from contaminated water is the most common risk factor for Vibrio conjunctivitis and keratitis. Nearly one half of reported Vibrio infections of the eye occurred along the U.S. coast of the Gulf of Mexico.

Adult↗
PubMed1998

Malignant nonteratoid medulloepithelioma of the ciliary body in an adult.

BACKGROUND: The authors describe a 62-year-old man with a malignant nonteratoid malignant medulloepithelioma of the ciliary body with extension into the anterior choroid and posterior chamber. He developed gradual loss of vision in his right eye, and a clinical diagnosis of malignant melanoma of the ciliary body and choroid was made. RESULTS: Histopathologic examination of the enucleated eye showed a malignant nonteratoid medulloepithelioma of the ciliary body with extension into the anterior choroid and posterior chamber. CONCLUSION: This report provides clinicopathologic evidence that intraocular medulloepithelioma can occur rarely in an adult. The lesion clinically may mimic a malignant melanoma. The authors also summarize five previously reported cases of this unusual lesion.

Choroid Neoplasms↗
PubMed1993

Glomus cell tumor of the eyelid.

BACKGROUND/METHODS: Glomus cell tumor, a vascular neoplasm, has been rarely reported to occur in the eyelid. The authors examined the clinicopathologic features of two patients with glomus cell tumor of the eyelid. RESULTS: The tumors occurred as enlarging violaceous to bluish masses. One patient had a solitary eyelid tumor that contained sheets of individual glomus cells. The other patient had eyelid and wrist tumors and multiple family members with similar lesions. CONCLUSION: This report provides clinicopathologic evidence that glomus cell tumor can occur in the eyelid in two different settings; in one setting, the tumor is solitary and sporadic, and in the second setting, it is multiple and familial.

Adolescent↗
PubMed1992

Malignant lymphoma of the ocular adnexa associated with the benign lymphoepithelial lesion of the parotid glands. Report of two cases.

BACKGROUND: The benign lymphoepithelial lesion of the salivary/lacrimal glands is generally regarded as a lymphoproliferative disorder that may be associated with Sjögren syndrome. Although lymphomatous transformation in patients with Sjögren syndrome is well documented, few reports have appeared describing similar findings in patients with a benign lymphoepithelial lesion. METHODS: The authors report the unusual occurrence of malignant lymphoma involving the ocular adnexa in two patients with a histopathologically documented benign lymphoepithelial lesion of the parotid glands. RESULTS: Both patients developed B-cell lymphomas. The eyelid tumor in case 1 expressed IgM/kappa cell surface markers by flow cytometry, and the orbital/conjunctival masses in case 2 showed neoplastic nodules of B cells that were only immunoreactive to lambda light chains (avidin-biotin complex method). CONCLUSION: To the authors' knowledge, this is the first report of ocular adnexal lymphoma arising in patients with a benign lymphoepithelial lesion of the parotid glands. This report establishes that ocular adnexal lymphoma may arise in a patient with a preexisting benign lymphoepithelial lesion.

Aged↗
PubMed1990

Familial hemifacial spasm.

Three male patients in successive generations of the same family developed acquired left-sided hemifacial spasm. Magnetic resonance imaging of the proband demonstrated a pontine vertebral artery anomaly near the root of the affected facial nerve. This family and a similar family that was recently presented illustrate several interesting features: (1) hemifacial spasm, from whatever cause, may be autosomal dominant; (2) the spasms involve the same side of the face in affected individuals within an affected family; and (3) the age of onset in familial cases may be younger than in nonfamilial cases.

Adult↗
PubMed1990

A clinicopathologic study of three carcinoid tumors metastatic to the orbit. Immunohistochemical, ultrastructural, and DNA flow cytometric studies.

Three patients with histopathologically proven orbital metastatic lesions from a carcinoid tumor are reported. Computed tomography (CT) disclosed a well-circumscribed orbital mass in two of three cases. Each tumor was studied by both light and electron microscopy as well as immunohistochemistry and DNA flow cytometry. A review of the literature discloses the relatively rare occurrence of carcinoid tumors metastasizing to the eye and orbit. With the exception of one case, the reported metastatic carcinoid tumors to the uvea all developed from primary bronchial carcinoids. In contrast, the vast majority of the reported orbital metastases arose from ileal carcinoids. Immunohistochemical markers such as chromogranin A, synaptophysin, and serotonin have proven to be useful diagnostic tools in evaluating carcinoid tumors. Furthermore, DNA flow cytometry may be of prognostic value in patients with metastatic carcinoid tumor.

Adult↗
PubMed1988

Diffuse uveal melanoma in a 5-year-old child.

A 5-year-old white boy developed a gray-tan discoloration with nodular thickening of the iris stroma in his left eye six weeks earlier. Ophthalmologic examination demonstrated keratic precipitates, peripheral anterior synechiae, and several pale-tan choroidal infiltrates in the involved eye. Cytologic examination of the aqueous humor and results of iris biopsy were interpreted as malignant melanoma of the iris, predominantly of the epithelioid cell type. The globe was enucleated one week later. Histopathologic examination disclosed a diffuse malignant melanoma of the uvea, mixed cell type, with multiple cysts of the ciliary epithelium. Study by electron microscopy indicated bizarre neoplastic melanocytes containing numerous immature melanosomes in various stages of melanogenesis, as well as fully melanized mature melanosomes. Eight months after enucleation the patient developed metastasis to the nasopharynx and base of the skull.

Child, Preschool↗
PubMed1988

Nocardial endophthalmitis: report of two cases studied histopathologically.

We report two cases of nocardial endophthalmitis. Case 1 is a 66-year-old man whose left eye was enucleated about one month after onset of decreased vision. Ophthalmoscopic examination disclosed multiple choroidal masses. Six weeks before the onset of ocular manifestations he had undergone a prolonged carotid endarterectomy with intraoperative complications. The source of the ocular infection was probably exogenous. Case 2 is a 49-year-old woman who had systemic sclerosis (scleroderma) with severe pulmonary insufficiency. She had received moderate doses of corticosteroids. Seventeen months after initiation of therapy she developed ocular manifestations leading to enucleation of the eye one month later. Histopathologically, the enucleated eyes in both cases showed numerous branching, Gram-positive, filamentous organisms involving mainly the plane of Bruch's membrane and the subretinal space. The nosological and microbiological aspects of nocardiosis are reviewed.

Aged↗
PubMed1985

Spontaneous intrastromal iris cyst. A case report with immunohistochemical and ultrastructural observations.

A 39-year-old man had an enlarging intrastromal iris cyst that obstructed the chamber angle inferotemporally and abutted the cornea. No history of ocular trauma or previous surgery was present. Iridocyclectomy with en bloc resection of the cyst was performed. The cyst was lined by one to three cell layers of focally pigmented epithelium that ultrastructurally exhibited desmosomes, tonofilaments, terminal bars, and apical microvilli. Additionally, membrane-bound melanin granules (melanosomal complexes) consistent with phagocytized uveal melanin granules were observed. Immunohistochemistry confirmed intracellular keratin. We conclude that the non-traumatic cyst reported herein is of surface ectodermal origin and suggest that such cysts be removed en bloc by sector iridectomy or iridocyclectomy if the lesion has been proven to enlarge.

Adult↗
PubMed1985

Hemangiopericytoma of the meninges of the optic nerve. A clinicopathologic report including electron microscopic observations.

A 61-year-old man complained of visual loss of his right eye following a systemic viral illness. At this time, complete ophthalmologic examination failed to disclose any abnormalities. Over the next months the patient developed dramatic loss of vision. Extensive workup, including CT scans, failed to clarify the underlying cause and a diagnosis of optic atropy following optic neuritis was made. The patient remained asymptomatic, but repeated CT scans depicted a fusiform enlargement of the intraorbital portion of the right optic nerve, three years after the onset of visual loss. The presumptive clinical diagnosis was optic nerve meningioma and the tumor was removed via a Krönlein procedure. Histopathologically, a highly vascularized intradural mass that led to compression atrophy of the optic nerve was present. The tumor was composed of fascicles of spindle-shaped cells that were interspersed among numerous, irregular vascular channels. Electron microscopically, the cells disclosed a lucent cytoplasm with a scarcity of organelles, prominent cytoplasmic filaments, numerous micropinocytotic vesicles and subplasmalemmal linear densities (hemidesmosomes). Poorly developed intercellular junctions were present between interdigitating cytoplasmic processes. The tumor cells surrounding the vascular units displayed a continuous basement membrane as well as all the features of well-differentiated pericytes. Away from vascular structures some tumor cells, which showed a focally discontinuous basement membrane, exhibited intermediate features between pericytes and fibroblasts. To the best of our knowledge, this is the first report of a hemangiopericytoma arising from the meninges of the optic nerve.

Cranial Nerve Neoplasms↗
PubMed1984

Amputation neuroma of the orbit. Report of two cases and review of the literature.

Two patients developed proptosis and a slowly enlarging mass with increasing discomfort in the orbital socket 17 and 25 years following enucleation. Preoperative CT scans revealed a single cystic structure within the orbits of each case with distinct soft tissue tumors adjacent to the cysts. The cystic structures and the adjacent solid masses were removed en bloc necessitating reconstruction of the orbits with a dermal fat pad (case 1) and a mucous membrane graft (case 2). Postoperatively the patients were free of complaints. Microscopically, the cystic structures were identified as conjunctival inclusion cysts while the soft tissue masses were traumatic neuromas with irregular tangles and whorls composed of proliferated axons, Schwann cells and connective tissue. Only seven amputation neuromas of the orbit have been reported. Pain related to the neuroma is rarely encountered and is probably caused by mechanical irritation of the amputation neuroma, by retracting scar tissue, or compression from an adjacent cystic mass as in one of our cases.

Adult↗
PubMed1983

Intravascular papillary endothelial hyperplasia of the orbit and ocular adnexa. A report of five cases.

This is a clinicopathologic study of five patients with intravascular papillary endothelial hyperplasia involving the orbit and ocular adnexa. The median age of the patients was 45 years. Three lesions were located in the orbit, one in the eyelid, and one in the eyebrow. Four lesions were located within a distended vein and one involved an artery. The walls of the vessel corresponded to the "capsule" of the circumscribed mass. The lumen disclosed different stages of organization of a thrombus with prominent endothelial cell proliferation centered around cores of collagenous tissue and fibrin. Electron microscopy of one lesion displayed spindle-shaped cells with features of endothelial cells forming a polarized basement membrane with numerous micropinocytotic vesicles on their plasmalemma. Some cells showed ultrastructural features of pericytes. The lesion, which may be confused with angiosarcoma, represents an unusual exuberant proliferation of vascular endothelium as a cellular response to the organization of a thrombus.

Adult↗
PubMed1983

Medulloepithelioma diagnosed by ultrasound and vitreous aspirate. Electron microscopic observations.

Ultrasonography and cytologic examination of the vitreous aspirate established the correct pre-enucleation diagnosis of medulloepithelioma in the case of an 8-year-old boy. The use of a muscle hook allowed the examiner to elevate the eye and bring the ciliary body into adequate ultrasonographic view. Histopathologic examination of the enucleated eye showed a partially pigmented mass composed of elongated neuroepithelial tubules and cords arising from the ciliary body inferiorly. Several tubules displayed a central lumen with rosette-like structures. The tumor was classified as a benign, nonteratoid medulloepithelioma. Electron microscopically the lumens of the rosettes contained myriad, slender microvilli, and were bordered by numerous terminal bar complexes and areas displaying zonula adherens and zonula occludens type junctions. Additionally, invaginating gap junctions, which clearly established that the tumor originated from the ciliary epithelium, were identified.

Biopsy, Needle↗
PubMed1982

'Cholesteatoma' of the orbit.

'Cholesteatoma' of the orbit is a variant of pseudotumor histologically characterized by masses of cholesterol crystals. We propose the term "epidermoid or true cholesteatoma" for lesions containing epithelial elements and refer to those nonepithelium-containing pseudotumors as "cholesterol granulomas." Important clinical features distinguish between epidermoid cholesteatomas and cholesterol granulomas of the orbit and justify a separation of these two pathologic entities.

Adolescent↗