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Biomedical subjects

M Borghi

Publications and source records attributed to M Borghi.

33 records · Page 2Linked to original sources
PubMed1985

[The law, a possible factor in the promotion of preventive medicine?].

The author observes first the uneven or even contradictory character of existing Swiss law, aggravated by a lack of coordination in terms of its application. He proposes several examples, though noting that the new Federal law on protection of the environment, for which a comprehensive approach has been adopted, might mark a new trend. In a second part, he describes the importance, in the field of prevention, of general constitutional principles the legislator has to take into account, above all in cases of envisaged limitations of fundamental rights. He proposes some legal guidelines which could influence the evolution of health law even in the absence of a direct restriction of individual freedom. An interdisciplinary approach is a necessary condition, especially a close collaboration between physician and lawyer.

Environmental Health↗
PubMed1983

A new catheter for peritoneal dialysis (two years of experience with Valli catheter).

The authors analyze the experience of more than 2 yrs of peritoneal dialysis with a new type of catheter. The catheter proposed allows higher flow rates and the maximum outflow of fluid even if malpositioned. The possibility of migration of the catheter is also reduced. The main new feature of this catheter consists in a perforated silastic balloon which protects the distal end of a standard Tenckhoff catheter.

Catheters, Indwelling↗
PubMed1979

[Cytosegregosomes in the kidney tubule cells in a case of acute renal insufficiency (ARI) caused by gentamycin].

The Authors describe one case of acute renal insufficiency in a patient treated with high doses of gentamicin over a period of three weeks. The documentation includes electron microscope observations of needle biopsy material revealing the presence of electron-dense masses (cytosegregosomes) in the epithelial cells of the proximal renal tubules, such as had previously been described only in animal experiments and human autopsy studies. The clinical course and favorable outcome of this case of gentamicin-induced renal failuse afford the opportunity for some interesting considerations concerning the kinetics and toxic proclivities of this aminoglycoside antibiotic.

Acute Kidney Injury↗
PubMed1978

[Use of hypnotism in transcutaneous renal biopsy. Preliminary results].

We wish to point out the outstanding importance of kidney biopsy in diagnosis of kidney diseases and enphasize the fact that it is very important for the patient to give one's full cooperation, in order to achieve the most successful results. Anxious subjects and children usually do not give this cooperation owing to their excessive emotional reactions to the special situation of the biopsy and so we think it useful to induce beforehand a hypnotic state in them, hoping that this would make it possible to carry out the research with the usual transcutaneous technique. In this research, which is to be considered as preliminary, ten patients were examined, nine of whom aged from three to fourteen and one aged forty-six. Eight subjects, out of ten, reached such a degree of hypnotic depth that it was possible to carry out the biopsy in a few minutes without noteworthy difficulties. The high ratio of successful cases and the lack of any considerable complications in their experiments enable the Authors, though still waiting for a wider range of data, to suggest since now the use of hypnosis whenever the patients prove reluctant to cooperation.

Adolescent↗
PubMedDate not supplied

Free D-amino acids in human cerebrospinal fluid of Alzheimer disease, multiple sclerosis, and healthy control subjects.

This is the first report of the presence of free D-amino acids in lumbar and ventricular human cerebrospinal fluid (CSF) of individuals with Alzheimer disease (AD) compared with CSF of normal control subjects and with individuals affected by multiple sclerosis, as an unrelated neurologic disorder. Free D-amino acids are present at significantly higher levels in AD CSF than normal CSF, whereas in the CSF of patients affected by multiple sclerosis, D-amino acids occurs at the same level as in the normal controls. The total D-amino acid content in ventricular CSF was 1.48 times higher in the AD than controls (26.4 vs 17.9 nmol/mL, p = 0.025). The total D-amino acid content was 1.43 times higher in AD lumbar CSF than controls (1.89 vs 1.32 nmol/mL, p = 0.001). D-Aspartate in particular was 2.74 times higher in AD ventricular CSF compared to normal ventricular CSF (3.34 vs 1.22 nmol/mL, p = 0.029). In lumbar CSF, D-aspartate was 1.5 times higher in AD than controls (0.054 vs 0.036 nmol/mL, p = 0.041). Previously we reported that D-amino acids are elevated in AD brain proteins associated with neurofibrillary tangles compared to normal brain proteins (D'Aniello et al., 1992c; Fisher et al., 1992a,b). Thus, the D-amino acids present in CSF may originate from degradation of brain proteins.

Alzheimer Disease↗
PubMedDate not supplied

[Osteomalacia from phosphate-binding substances (author's transl)].

A case is told with osseous fractures occurred during uremia in a periodically dialyzed man treated with phosphate-binding substances in excessive doses. The healing time is studied to value the effectiveness of normalized phosphatemia and the vitamin D treatment necessity.

Adult↗