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M Borrelli

Publications and source records attributed to M Borrelli.

At least 73 records · Page 4Linked to original sources
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Central serous chorioretinopathy and Helicobacter pylori.

PURPOSE: This study was designed to evaluate the prevalence of Helicobacter pylori infection in patients with central serous chorioretinopathy (CSC). METHODS: Retrospective observational case series. A group of 23 patients (22 men and 1 woman, age range 34-62 years, median age 47 years) with diagnosis of CSC, confirmed by fluorescein angiogram, and a control group of 23 consecutive patients (22 men and 1 woman, age range 41-69 years, median age 50 years) referred to our Department for retinal disease other than CSC were studied. Each patient provided peripheral venous blood samples and a stool specimen, which were analyzed at the Department of Gastroenterology and Microbiology at the same university. H. pylori infection was determined by measurement of IgG anti-bodies to H. pylori and by determination of H. pylori antigens in the stool specimens by enzyme-linked immunosorbent assay technique. Patients were defined as H. pylori infected if both tests were positive. RESULTS: The prevalence of H. pylori infection was 78.2% (95% CI, 56%-92%) in CSC patients and 43.5% (95% CI, 23%-65%) in control subjects (p<0.03 by two-tail ed Fisher exact test). The odds ratio for CSC associated with H. pylori infection was 4.6 (95% CI 1.28-16.9). CONCLUSIONS: The results of this study show that the prevalence of H. pylori infection seems to be significantly higher in patients with CSC than in control s. H. pylori infection may represent a risk factor in patients with CSC.

Adult↗
PubMedDate not supplied

Evaluation with MR, perfusion MR and cerebral flowSPECT in NPSLE patients.

PURPOSE: To compare the performance of MR, cerebral flow SPECT and perfusion MRI (PWI) in NPSLE patients by using image co-registration. MATERIALS AND METHODS: 20 SLE patients underwent MR (T2-weighted FLAIR), perfusion and diffusion MR, and SPECT (after ( 99m)Tc-HMPAO intravenous injection). Two experienced operators analysed the images both independently and jointly after multi-modal volumetric co-registration ("Statistical Parametric Mapping" software, based on the Maximization of mutual information method). RESULTS: The FLAIR examination depicted 82 small lesions in 11/20 patients. Perfusion SPECT showed 43 hypoperfused areas in 17/20 patients. PWI showed 13 hypoperfused areas in 10/20 patients. After co-registration of images, anatomical agreement between SPECT and PWI was found in 10 hypoperfused areas (8 patients). Co-registration with FLAIR showed some false positives, more frequent in SPECT (9/43 areas) than in PWI (2/13 areas). DISCUSSION AND CONCLUSIONS: The FLAIR examination confirmed its high sensitivity in detecting lesions. Perfusion SPECT confirmed high sensitivity for the detection of hypoperfused cerebral areas. PWI showed fewer areas of cerebral hypoperfusion than did SPECT. The disagreement between SPECT and PWI may be related to the different modalities for disease detection. The anatomical agreement of hypoperfused areas between SPECT and PWI, assessed after co-registration, can suggest the prognostic hypothesis of delayed appearance of permanent parenchymal lesions. Co-registration modality, being able to show some false positives, seems to be a valid support for the interpretation of SPECT and PWI findings; the joint analysis of SPECT and PWI highlighted the capability of PWI for the interpretation of uncertain cases.

Adult↗