Biomedical subjects
Publications and source records attributed to M Borsa.
A mass fragmentographic technique was used to study the pharmacokinetic behavior of SCMC-Lys in patients with acute exacerbations of chronic bronchitis and with dense expectoration. Serum and urine levels, as well as bronchial mucus levels and their correlations, were determined. The data suggest that SCMC-Lys diffuses well into bronchial mucus, a useful feature for a mucolytic drug.
A high-performance liquid chromatographic method for the quantitation of the new anti-secretory and antiulcer drug trithiozine in human plasma and urine is reported. The procedure is simple and precise; it allows the simultaneous determination of therapeutic doses of the drug and its three main metabolites, namely, 4-(3,4,5-trimethoxythiobenzoyl)tetrahydro-1,4-oxazine S-oxide, 4-(3,4,5-trimethoxybenzoyl)tetrahydro-1,4-oxazine, and 2-hydroxy-4-(3,4,5-trimethoxybenzoyl)tetrahydro-1,4-oxazine.
Explore the source record for details and available documents.
Wistar rats, aged 30 and 90 days, received Aldrin and Lindan treatment (8 ppm or 11 ppm) over 60 days, followed by inoculation of E. coli. The capacity of antibody formation was changed but not inhibited. Functional disorders occurred in the thymus (decline of nucleic acids), adrenal gland (decline of Vitamin C), and in the protein synthesis. The toxicity of even smaller Aldrin doses obviously was stronger than that of Lindan. The toxicity of either substance to younger animals was stronger than to individuals in more advanced age.
Explore the source record for details and available documents.
Chickens received Mecadox treatment for 28 days, beginning at the age of five days, with the daily rations having been 1 g in 1 kg feedstuff. Changes were caused in two periods. The first therapeutic period, first to 14th days, was characterised by rise in total protein, DNA, RNA, amino nitrogen, and ascorbic acid in the adrenal gland as well as by rise in body mass, however, with no change of thymus and bursa mass. The second therapeutic period, between the 14th and 28 th days, led to decline in the above parameters and to involution of the lymphatic organs. The conclusion is suggested that biological stimulation can be achieved only in response to short-time Mecadox treatment.
Eight weeks of Entomoxan administration to chickens (15 mg/kg live weight) were followed by significant change of certain physiological parameters relating to the blood, liver, suprarenal bodies, and sexual glands. Such variation was taken to indicate the presence of stress suffered by the animals' impairment of carbohydrate and fat metabolism, and defects of hormonal regulation.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.