Action of mercuric chloride during one cycle of seminiferous epithelium in the rat.
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Animals↗
Biomedical subjects
M Bose
Publications and source records attributed to M Bose.
Very low calorie diets and pre-fasting prolonged QT interval. A hidden potential danger.
The association of torsade de pointes and a prolonged electrocardiographic QT interval is well described. A prolonged QT interval may be congenital or acquired in several ways--by the use of anti-arrhythmic agents exemplified by quinidine, by the presence of hypocalcaemia or hypokalaemia, by the use of psychotropic drugs, and by the presence of intrinsic cardiac disease or bradycardias. Possibly less well appreciated is the potential for drastic weight loss to prolong the QT interval, as the present case report illustrates. A young woman weighing 244 pounds lost 24 pounds in two weeks with a consequent prolongation of QTc interval from pre-diet value of 0.57 seconds to 0.72 seconds at admission, when severely symptomatic paroxysms of torsade de pointes were recorded. Successful therapy with lignocaine and prompt re-feeding suppressed the arrhythmia and, three days later, the QTc was reduced to almost its pre-diet state. A (UK) DHSS report offers guidelines in the use of very low calorie diets. This case suggests that a pre-diet electrocardiogram should be carefully assessed for QT prolongation before initiation of dieting to achieve serious weight loss.
Adolescent↗
Inhalation toxicity of methylisocyanate: assessment of germ cell mutagenicity and reproductive effects in rats.
Adult male Wistar rats were exposed to methylisocyanate (MIC, 3.2 mg/l, single inhalation exposure for 8 min under static condition) or ethyl methanesulphonate (EMS, 150 mg/kg, single ip dose) for the assessment of germ cell mutagenicity and reproductive effects. Sequential matings of treated males with normal females on days 1-7, 8-14 and 15-21 post-exposure did not indicate any induction of dominant lethal mutation (increased frequency of preimplantation losses and early fetal deaths) by MIC but it was significantly induced by EMS as compared to respective controls. Males, necropsied after 21 days of exposure, showed no effect of MIC on epididymal sperm density and morphology. EMS also had no effect on sperm density but it significantly induced morphological abnormalities in sperm as compared to untreated controls. There was an acute and transitional reduction in reproductive performance (10-21%) of MIC-exposed males during days 1-14 post-exposure followed by recovery to the normal level during days 15-21 post-exposure. The progeny of MIC-exposed males was also normal in terms of litter size, litter weight, neonatal survival and body weight gain in litters up to 10 days post-partem. It is concluded with the evidence at hand that the observed failure of MIC to cause germ cell mutagenicity is related to its poor biodistribution to the target site(s) and a transient reduction in the reproductive performance of MIC-exposed males is a result of general stress and disconsolate copulation.
Administration, Inhalation↗
[Paresthesias].
A 23-year-old patient suddenly experienced paresthesia in both legs which progressively ascended to the region of the umbilicus and finally also occurred in all fingers. The physical examination revealed a decreased sensation for touch, discrimination and vibration in all paresthetical regions and on the stem even up to dermatome C5. A mild elevation of the protein content, a mononuclear pleocytosis and oligoclonal bands were found in the cerebrospinal fluid. Magnetic resonance imaging of the cervical spinal cord showed a hyperintensive lesion in the region of the posterior tract at C6. With respect to these findings and after exclusion of other neurological affections, multiple sclerosis was diagnosed. The symptoms subsided spontaneously within five weeks, and the patient was discharged without any complaints. The diagnostic accuracy of the various findings is discussed.
Adult↗
[Studies on the reproducibility of recordings obtained with the Condylocomp LR 2].
The reproducibility of movement recordings obtained with the Condylocomp LR 2 was tested on three different types of articulator (Dentatus, SAM 2, Stuart). Additionally, reproducibility of TMJ movement recordings was tested on 18 subjects. Differences of +/- 2 degrees to the real angles, when working carefully, seem to be precise enough. The Condylocomp LR 2 seems to be a useful means for diagnosing and documenting TMJ movements, because it allows dynamic recordings with high resolution and correction of geometric errors.
Adult↗
Mechanism and pathway of glucose transportation in a digenetic trematode Ceylonocotyle scoliocoelium.
The mode of absorption, kinetics and mechanism of transportation of 14C--glucose in a digenetic trematode, Ceylonocotyle scoliocoelium were studied by culturing the trematodes under in vitro condition in Hank's saline supplemented with radioactive tracer. It was then followed separately by autoradiography and liquid scintillation. Autoradiographic study reveals that the maximum amount of glucose uptake occurs through cuticle whereas the role of intestinal canal is insignificant in this respect. Maximum cpm is recorded in the precipitate followed by TCA treatment. This is due to the presence of a protein-bound 14C-glucose which is assumed as the carrier protein. The inhibitor, phlorizin, used here presumably acts noncompetitively.
Absorption↗
Absence of antibodies to human immunodeficiency virus (HIV) in health workers after hepatitis B vaccination.
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Acquired Immunodeficiency Syndrome↗
Serratia marcescens septicaemia in newborn.
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Anti-Bacterial Agents↗
Epidemic of Japanese encephalitis in Bankura (1973): clinico-pathological findings.
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Disease Outbreaks↗
[Plasma progesterone of ewes at the end of the gestational period after destruction of the fetal hypophysis. Effect of dexamethasone administration].
Destruction of the foetal pituitary has been performed in ewes at day 120 of pregnancy and progesterone has been assayed by radioimmunology. The plasma progesterone remains at a steady level from day 138 and throughout the prolongation of pregnancy, even after injection of dexamethasone on day 145.
Animals↗