[Personal experience with posterior transsphincteric procto-rectotomy].
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Adult↗
Biomedical subjects
M Bozanić
Publications and source records attributed to M Bozanić.
[Diagnostic value of the NBT-PABA test in the functional evaluation of the exocrine pancreas].
N benzoyl-L-tyrosil PABA was orally administered to 13 controls and 35 patients with pancreatic disease: 7 with chronic exocrine pancreatic disease, 7 patients after an attack of acute pancreatitis, 3 with carcinoma of the pancreas, 8 with biliary tract disease and 10 with diabetes. The amount of PABA excreted serves as parameter exocrine pancreatic function. PABA excretion in patients with chronic pancreatitis (p < 0.01) and diabetes (p < 0.05) was significantly less then in controls. The present data justify further investigation of this procedure as a possible new oral test of exocrine pancreatic function.
4-Aminobenzoic Acid↗
[Serum antithyroid antibodies in patients with pernicious anemia].
We investigated the incidence of thyroid auto-antibodies and their relationship to antigastric antibodies in 20 euthyroid patients with pernicious anaemia. To evaluate possible thyroid dysfunction we also measured total level of thyroid hormones (TT3 and TT4) and TSH in our patients. Histologic evidence of autoimmune atrophic gastritis and intestinal metaplasia was obtained in 15 patients. We found that it was surprisingly high incidence of thyroid auto-antibodies in patients with pernicious anaemia, particularly in the group with intestinal metaplasia (antithyreoglobulin antibodies 71% and antimicrosomal antibodies 100%). The incidence of antigastric antibodies in these patients was similar to that of those with significant antithyroid antibodies (16/18). Total triiodo thyronine and TSH were significantly higher in the patients with pernicious anaemia than in the control group (p less than 0.05), in the normal range. The results of our study suggest that this upset in immunological physiology is due to a more generalized defect in immune tolerance.
Aged↗
[Serum gastrin in patients with diabetes].
We evaluated the basal and postprandial circulating levels of gastrin in 20 diabetic patients and in 20 normal subject. The basal gastrin concentrations were not statistically different in comparison to controls. The blood tests provoked increased circulating levels of gastrin. In our study diabetes significantly enhanced that response, particularly in diabetics with severe disease, peripheral neuropathy and in untreated patients. Histologic evidence of antral hyperplasia was obtained in 7 patients; atrophic gastritis and intestinal metaplasia were found in 3 diabetics. We postulate that postprandial gastrin levels raised secondary to achlorhydria, common in diabetics.
Diabetes Mellitus↗
[Lipids and total bile acids in the blood of patients with inflammatory bowel diseases].
We evaluated the total plasma bile acids, total lipids, total cholesterol, total triglicerides, LDL-cholesterol, HDL-cholesterol, phospholipids and lipoproteins (APOA-A and APO-B) in 25 patients with inflammatory bowel disease: 20 with ulcerative colitis (UC) and 5 with Crohn's disease. In comparison to 17 healthy volunteers, the total plasma bile acids were decreased in all patients. The serum level of total cholesterol, LDL-Ch, HDL-ch and APO-A was significantly lower in patients with Crohn's disease and ulcerative colitis (p less than 0.01) than in normal controls; total triglycerides and APO-B were decreased only in the group with Crohn's disease (p less than 0.05). Thus, decreased values of total plasma bile acids malabsorption, and they suggest a more important romalabsortion, and they suggest a more important role of the colon in the preservation of bile acids.
Adult↗
[Hormone levels in patients with alcoholic liver cirrhosis].
The purpose of the study was to evaluate some of the hormones in 20 patients with alcoholic cirrhosis. We investigated the diurnal rhythmicity of some of the hormones (cortisol, follicle-stimulating hormone-FSH, luteinizing hormone-LH, growth hormone-LH, prolactin-PRL) and basal serum concentrations of thyroid-stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4) and testosterone, as well as gastrin and insulin, using provocative tests. Statistical analysis of the results obtained from the observed patients compared with controls, showed significantly lower concentrations of T3 (p less than 0.05), cortisol (p less than 0.05), testosterone (p less than 0.05) and FSH (p less than 0.05), and significantly higher (p less than 0.01) serum concentration of prolactin. Then, in the cirrhotic group the serum concentrations of gastrin and insulin increased significantly (p less than 0.01), together with the disorders of carbohydrate metabolism (impaired glucose tolerance and diabetes mellitus. The described disturbances of some of the observed hormones are complex, particularly in their relationship by which the clinical picture of the cirrhotic patients can be explained.
Adult↗
[Serum cholesterol and triglycerides in patients with benign and malignant tumors of the colon and rectum].
There are many epidemiological papers on the relation of lipids especially of cholesterol, and the incidence of colorectal adenoma and cancer. In the studies of pathogenesis of the cancer of the large intestine attention is paid to the role of certain lipoproteins of bile acids and certain gastrointestinal hormones. We examined 30 patients: 10 were healthy subjects (the control group), 9 with colorectal adenoma, 2 with villous adenoma and 9 with adenocarcinoma of the colon and the rectum. The study concerned: total lipids, total cholesterol, total triglycerides, LDL cholesterol, HDL cholesterol, phospholipids, gastrinaemia and insulinaemia. Statistical analysis of the obtained results showed that hypocholesterolemia followed the incidence of adenocarcinoma. This is in accordance with the most frequently quoted literature. The incidence of hypergastrinaemia, however, was found primarily in the patients with villous adenoma, which indicates possible secretory function of the studied tumours.
Adult↗