Biomedical subjects
Publications and source records attributed to M Brückner.
A young man with Weber B fracture had adrenalectomy under the suspicion of pheochromocytoma on the right side. Surprisingly hematoma of the right adrenal gland was found. This case is presented to point out the mechanism of trauma and diagnostic possibilities of the injury.
Eight patients suffering from leakage around the esophagus were treated with a transnasally fixed Celestin tube. All of the subjects had exhibited an anastomotic dehiscence after having undergone esophageal resection, cardia resection or total gastrectomy. Following treatment, in all cases the anastomoses healed quickly with no complications.
The advantages and problems of different types of artificial feeding are discussed. For patients needing long-term nutritional support, we see the following special advantages of PEG: physiological enteral nutrition with an only small risk of tube dislocation, no additional handicap of the natural swallowing procedure and without stigmatizing the patient by an external visible tube (Tab. 3). To help to spread this method of artificial feeding for the benefit of the patient, this article gives some informations on how to cope with the problems that might occur when using PEG (for example: a diet plan for building up the tube food nutrition (Tab. 4).
Paired helical filaments (PHF) were isolated from the cerebral cortex of patients with Alzheimer's disease (AD) by a combination of SDS treatment and density gradient centrifugation according to the method of Ihara et al. (1983). The protein component of the preparation was extracted with formic acid and Balb/c mice were used for immunization. Hybridoma supernatants were screened by immunocytochemical staining, by an ELISA assay, and by immunoblotting of SDS-PAGE, the latter both using the PHF preparation as antigen. One hybridoma which showed a strong reactivity with PHF in both the ELISA assay and immunocytochemistry was then used to produce ascites fluid in Balb/c mice. Antibodies reacted immunocytochemically with neurofibrillary tangles and neurites involved in plaque formation in AD but did not show a cross-reaction to human control brain and rat brain. The results indicate that the antibody which has been raised reacts with an antigen component of PHF.
Over the last 12 years, treatment of bleeding esophageal and gastric varices has improved considerably. By the use of new techniques and with increased experience the results of endoscopic sclerotherapy have been optimized. Acute variceal bleeding, esophageal or gastric, can now be reliably and definitively stopped using the tissue adhesive Histoacryl Blau. This is also applicable to all patients irrespective of their liver status at presentation. As expected, the mortality of acute variceal bleeders has decreased considerably, no death from bleeding occurring in the last 5 years. This has obviated the need for emergency surgery, balloon tamponade or vasopressin infusion. Using an aggressive sclerotherapy technique in the bleeding-free interval, varices of all grades can now be effectively eliminated within an average of 3 sessions covering 3-4 weeks. With the intra- cum peri-variceal injection technique not only are the visible veins eradicated, but also fibrosis of the inner esophageal wall is achieved at the same time. If careful attention is paid to certain details of the technique and instruments, and with close follow-up, patients of portal hypertension can now live well in terms of liver function, without the danger of further variceal bleeding.
We present a case report of a patient with two large pancreatic abscesses and an associated colonic fistula originating from acute gallstone pancreatitis, which we treated endoscopically. The common bile duct stones were extracted after a papillotomy. The abscess in the pancreatic head was drained into the duodenum and the one in the pancreatic tail irrigated through a nasopancreatic catheter using normal saline mixed with gentamycin. The colonic fistula was finally obliterated using a two-component fibrin glue.
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We report on a new method of stent exchange using a threaded device that enables removal of the clogged stent while simultaneously maintaining the original pathway without withdrawing the endoscope. With this method stent replacement has become more reliable, safer, simpler and quicker. This technique is also suitable for removal of stents dislodged inside the duct.
A holding device was introduced by mean teeth for transplantation can be fixed during all extraoral procedure.
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We report on our 10 years' experience in endoscopic sclerotherapy. A total of 1054 patients (90% of them with liver cirrhosis) were treated. During the first seven years (1978-1985) the hospital mortality of the bleeders was 31.5%. During the last three years after the introduction of tissue adhesive the mortality rate has falling to 14.5%. The rate of patients with late recurrent hemorrhages sank from 16.6 to 7.8%. This improvement of the results is in our opinion due to the more sufficient control of bleeding and treatment of fundic varices. The sclerotherapy in the interval has an overall hospital mortality of 5-6% (for all patients regardless the Child-classification). Perforations occurred in less than 1% and stenoses requiring bougienage in 2-3%. The cumulative survival curve shows that after 10 years about 40% of the patients are still alive.
We present a simple technique for the fixation of esophageal tubes. The endoprosthesis is anchored to a thin polyethylene catheter which is passed transnasally and attached to the ear. This method of treatment effectively prevents dislodgement. It is also suitable for placing a tube into the esophagus when the stenosis essential for anchorage is absent, for example in large fistulae, perforations, or suture dehiscence.
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Mechanically dissociated cells from embryonic rat brain regions (telencephalon and metencephalon 15-16 days gestation) reassociate in a rotation culture to form aggregates. These reaggregate cultures show a variety of developmental phenomena, expression of specific cell types and the formation of synapses as the most prominent ultrastructural change. The biochemical maturation is evident in increasing specific activities of choline acetyltransferase (ChAT, EC 2.3.1.6.) and acetylcholinesterase (AChE, EC 3.1.1.7.). The binding of 3H-quinuclidinylbenzilate(3H-QNB) represents the presence of the muscarinic acetylcholine receptor (mAChR) in these cultures. The expression of the cholinergic character was also shown by histochemical demonstration of specific AChE activity in cryostat sections of reaggregates.