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Biomedical subjects

M Brandt

Publications and source records attributed to M Brandt.

At least 19 recordsLinked to original sources
PubMed1979

Evaluation of the chronic inhalation toxicity of a manganese oxide aerosol. III. Pulmonary function, electromyograms, limb tremor, and tissue manganese data.

Monkeys and rats were exposed to 11.6, 112.5, and 1152 micrograms Mn/m3 as an Mn3O4 aerosol twenty-four hours per day for nine months. Various evaluations of pulmonary function, electromyographic activity, limb tremor, and tissue manganese levels were conducted. No exposure related effects on pulmonary function, limb tremor, or electromyographic activity were observed. After nine months of exposure Mn levels were elevated in a near dose related manner in kidney, lung, spleen, and blood. However, by six months postexposure there were no differences as compared to the control group in tissue Mn levels which could be attributed to the exposure conditions.

Aerosols↗
PubMed1978

The effects of stress on cortical bone thickness in rodents.

The right and left femora of three groups of rodents, cold stressed, noise stressed, and heat stressed, were sectioned transversely at the most inferior point of the third trochanter. Cortical bone thickness of the proximal section for all three groups was determined by measuring an enlargement obtained with a Wild stereo microscope with a camera lucida drawing attachment. Cold stressed animals were found to have significantly thinner cortical bone than did controls, noise stressed animals did not differ from controls, and heat stressed animals had thinner cortical bone than did controls. It is concluded that stress may be responsible for the thinner cortex of cold and heat stressed animals, but that other factors may be at work and that it is not possible to tell whether different types of stress act through the same or through different mechanisms.

Animals↗
PubMed1977

[Growth hormone, LH and FSH under function dynamical conditions in serum and basic corticol and testosterone serum levels in brain-injured patients during dexamethasone treatment].

In 14 male patients with severe head injury the following hormones were measured by radioimmunological methods in plasma: Basal levels of LH, FSH, GH, testosterone and total corticoids; furthermore LH-releasing-hormone- and insulin-hypoglycaemia-tests were done. The investigations have shown, that in patients with severe head injury no essential impairment of the hypothalamus-hypophyseal-system controlled by LH-, FSH- and GH-secretion could be detected. Diminished testosterone and accelerated LH-levels are measurable, whereas total corticoids were not significantly accelerated. Because of treatment with dexamethasone the effect of this substance has to be discussed.

Adolescent↗
PubMed1977

Occult thoracic and sacral meningoceles.

Two cases of occult meningoceles are reported. The first case exhibited a combination of thoracic meningocele and neurofibromatosis with additional generalised osteomalacia. The second case was an anterior sacral meningocele. Based on these reports pathogenesis, diagnosis and therapy are discussed. The importance of myelography for the diagnosis of this condition and the indications for operative treatment are pointed out.

Adult↗
PubMed1977

[Contribution to carcinosarcoma of the uterus (author's transl)].

The histogenesis of carcinosarcomas of the uterus is not clear yet. The different histologic structures of a collisions-tumor which is characterized by a secondary intermingling of sarcomatous and carcinomatous elements are described, and their etiolgy and pathogenesis are discussed.

Aged↗