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Biomedical subjects

M Breda

Publications and source records attributed to M Breda.

At least 37 records · Page 2Linked to original sources
PubMed1992

A study of the effects of rifabutin on isoniazid pharmacokinetics and metabolism in healthy volunteers.

The effect of repeated administration of rifabutin on the pharmacokinetics and metabolism of isoniazid was evaluated in 6 healthy volunteers. The subjects received on day 1 and 9 a single oral dose of 300 mg isoniazid and from day 2 to 8 a single daily oral dose of 300 mg rifabutin. Two out of 6 subjects were shown to be rapid acetylators. No significant modification of the plasma pharmacokinetic profiles of isoniazid and acetylisoniazid was found. Evidence exists in the present study for autoinduction of rifabutin metabolism; this is shown by the lower plasma concentrations obtained 24 h after the seventh dose as compared to the theoretical concentrations.

Acetylation↗
PubMed1991

Plasma morphine and morphine-6-glucuronide patterns in cancer patients after oral, subcutaneous, sublabial and rectal short-term administration.

Clinical studies on the effectiveness of morphine administered through different routes are contradictory. In order to further elucidate this point, the plasma concentrations of morphine and its 3- and 6-glucuronated metabolites were measured after short-term oral, sublabial, rectal and subcutaneous administration of the opiate. The bioavailability of free morphine and the 6-glucuronated active metabolite was comparable through the different routes. It was concluded that the choice of the route of morphine administration should be mainly guided by the needs of each individual patient.

Aged↗
PubMed1990

Effect of nifedipine on morphine-induced analgesia.

Experimental data show that opiates interfere with calcium influx in the cell and that some calcium-channel blockers are analgesic. We therefore studied the effect of the calcium-receptor blocker nifedipine on the analgesic effect of morphine in the rat, using tail-flick responses, and in humans, using measurements of the intensity of postoperative pain. In both the experimental animals and humans nifedipine significantly (P less than 0.001) increased the analgesic effect of morphine independently of any effect on the metabolism of morphine. Respiratory and cardiovascular functions were not significantly changed by nifedipine. The data indicate that Ca2+ is important in mediating the analgesic effects of opiates and suggest that calcium-receptor blockers might find a place in the treatment of pain.

Adult↗
PubMed1983

Rupture of multiple hepatic adenoma and oral contraceptive use: a case report.

A 38-year-old woman was seen with a hemoperitoneum caused by rupture of a hepatic adenoma of the right lobe. The patient had been taking oral contraceptives for ten years, but discontinued their use three years previously. During the postoperative course a second adenoma of the contralateral lobe, not diagnosed at the first operation, ruptured. The relationship between oral contraceptive use and hepatic cell adenoma is briefly reviewed.

Adenoma↗
PubMed1982

[Comparison of the growth of subjects from 6 to 12 years of age in the province of Naples and the province of L'Aquila].

The authors studied weight, height and thoracic circumference of 419 children 6 to 12 years old who were born in Naples county. They transcribed data on special anthropometrical forms and computed arithmetical mean and standard deviation for every series of biometrical values. Then they plotted the graphs of growth-state obtaining so the growth curves. Comparing these graphs with those obtained by the same methods in children from L'Aquila of the same age, the following conclusions can be drawn: 1) Neapolitan children have a slight more increased growth with respect to children born in L'Aquila; 2) the growth of both groups is similar since the shape of their growth curves is overlapping.

Anthropometry↗
PubMed1982

[Phospholipid fractions of the hypothalamus and liver morphology and function in the rat].

The Authors studied the effects induced by long administration of hypothalamic phospholipids on the rat liver. They showed that the most important histologic changes can be observed in the liver of animals who received the longest treatment. Such changes consist of significant infiltration of lymphocytes and red blood cells that have overflowed into the pericentrolobular space. This picture of a not-too-serious blood stasis could justify the alterations of the epatocytes contemporarily observed.

Animals↗
PubMed1982

[Observations of the thyroid function after treatment of the laryngeal carcinoma with 60Co].

We have examined 16 patients with laryngeal carcinomas who had been submitted to laryngectomy and subsequent 60Co therapy (dose 60-70 Gy, thyroid exposure 50-60 Gy). After an interval of several years, some patients showed alterations of the thyroid function, i.e. a problematic hypothyreosis in two patients and a latent or compensated hypothyreosis in six patients. The latter could be demonstrated by several functional in-vitro tests (T3 saturation, T4, T3-RIA, TSHV, TRH). Especially the TRH test showed significant alterations in four patients. The results obtained from this relatively small number of cases correspond to the descriptions in literature of irradiation damages to the thyroid caused by the treatment of the laryngeal carcinoma. Despite the necessity of further control examinations of a greater number of patients, the results achieved hitherto suggest a prophylactic or substituting hormone treatment during the radiotherapy of the laryngeal carcinoma.

Adult↗
PubMed1981

Lack of AKR ecotropic provirus amplification in AKR leukemic thymuses.

A DNA fragment from the 3' region of a molecularly cloned AKR ecotropic provirus was identified to be specific for the AKR ecotropic murine leukemia virus (MuLV). This selected DNA fragment was used to analyze the integrated MuLV proviruses in normal and leukemic tissue DNAs of AKR mice. In comparison with a DNA fragment from the 5' region of the cloned AKR genome or one representing the entire genome, this selected probe hybridized to only a few MuLV proviruses. By comparing transformed and nontransformed tissue DNAs, it appeared that no amplification of proviral sequences related to the AKR ecotropic MuLV had occurred in thymomas of AKR mice during the development of leukemia in these animals. Analysis of the AKR ecotropic MuLV proviruses revealed a significant degree of polymorphism for these sequences among individuals in the AKR/J strain of mouse.

AKR murine leukemia virus↗
PubMed1981

[Uncommon locations of celomic cysts: a possible cause of error in mediastinal radiology (author's transl)].

Five cases of uncommon locations of mediastinal celomic cysts are presented. All cases were surgically proved. The importance of these locations in the differential diagnosis of mediastinal masses is stressed. The evaluation of their inner structure by computerized tomography is, without doubt, the best progress in radiological diagnosis of the mediastinum. This method allows, atraumatically, to confirm or exclude the cystic nature of the lesion in one with its precise spatial localization.

Adult↗