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Biomedical subjects

M Brion

Publications and source records attributed to M Brion.

11 recordsLinked to original sources
PubMed1979

[2d-generation cephalosporins in the treatment of gram-negative superinfections].

The second generation cephalosporins are those drugs that are totally or partially resistant to betalactamases (cefamandole, cefuroxime) or the cephamycins (cefoxitine). This property allows them to destroy the enterobacteria resistant to cefalotine and they may have a place in the treatment of certain post-operative infections (abdominal, gynaecological, urinary) on their own or in combination with an aminoglycoside. They also may be of use in combination with an aminoglycoside in the management of secondary septicaemia infections. Outside of these indications which are dependent on the bacteriological findings, their use should be limited even when there is an absence of organisms that are Cefalotine sensitive on the antibiogram. This careful approach (which applies particularly for cefotaxine) may be abandoned once a certain quantity of resistant strains have emerged. For the time being, the second generation cephalosporins ought to be used only for specific indications, and as a general rule should not be first line antibiotic treatment.

Cephalosporins↗
PubMed1977

[Current place of the Pneumococcus in infectious pathology].

This work regroups an important number of acute pneumococcal infections with septicemia, which recalls that these infections are of current importance, owing to their frequency and poor prognosis. Present diagnositc, clinical, radiological and bacteriological methods are discussed and criticised. An important, but not exclusive place, is reserved for routine blood culture. Finally, the authors discuss future prospects of acute pneumococcal infections, mainly diagnostic and prophylactic.

Acute Disease↗
PubMedDate not supplied

[Ultrastructural odontological study of a case of Papillon-Lefèvre disease].

An ultrastructural study of the teeth and alveolar bone was carried out in a case of Papillon-Lefevre disease, using sweep electron microscopy. There were structural abnormalities of the enamel, numerous zones of cement resorption, the absence of mineralisation of the parodontal fibres inserted in the cement. Osteogenesis was disturbed and the lamina dura showed a granular pattern without any defined orientation.

Alveolar Process↗