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Biomedical subjects

M Brish

Publications and source records attributed to M Brish.

7 recordsLinked to original sources
PubMed1979

Breast milk thyroxine and not cow's milk may mitigate and delay the clinical picture of neonatal hypothyroidism.

Thyroxine concentration was measured in human milk and Cow's milk products by a specific radioimmunoassay. The mean (+/- S.E.M.) milk T4 concentration during the first 5 days postpartum was 0.7 +/- 0.3 microgram/dl (n = 11). The mean T4 concentration between 6-49 days postpartum rose to 3.1 +/- 0.2 microgram/dl (n = 108), falling after 50 days to a mean of 1.4 +/- 0.2 microgram/dl (n = 39). The mean (+/- S.E.M.) T3 concentration in breast milk in the first 50 days postpartum was 386 +/- 17 ng/dl (n = 56). T4 concentration in cow's milk products was less than 0.3 microgram/dl. Thyroxine concentration in 24 hours breast milk collection ranged from 0.7 to 7.7 microgram/dl and the total T4 in this milk ranged from 0.7 to 28 microgram/day. These data suggest that milk of human but not bovine origin may provide a significant exogenous source of T4 to the premature infant. This amount of exogenous T4 which is insufficient in preventing the proceeding of neonatal hypothyroidism, may delay the clinical recognition of this disorder. This once again emphasized the importance of early screening for neonatal hypothyroidism.

Animals↗
PubMed1979

Intra-amniotic thyroxine (T4) absorption by the premature human foetus.

We reported previously on the beneficial influence of intra-amniotic T4 injection in accelerating human foetal lung maturity. Twenty-four h after T4 (250 microgram) intra-amniotic injection, the mean cord serum T4 concentration in 13 premature newborns was 17 +/- 2.1 microgram/100 ml, while the T4 concentration in a matched group was only 11.6 +/- 0.9 microgram/100 ml: in 5 of the infants who received intra-amniotic thyroxine T4 was measured 12 h post-partum and rose from 16.1 +/- 1.8 to 24.3 +/- 2.6 microgram/100 ml. No change in maternal T4 concentration was observed. The mean cord serum T4 concentration in premature newborns delivered more than 3 days following T4 intra-amniotic injection, however, was not significantly different from that of the controls. These data suggest that T4 (250 microgram) injected intraamniotically is absorbed by the premature human foetus. Furthermore, the hyperthyroxinaemia is only transient, and does not prevent the post-natal T4 surge.

Absorption↗
PubMed1978

Enhancement of fetal lung maturity by intra-amniotic administration of thyroid hormone.

Following preliminary results in animal studies demonstrating that thyroxine (T4) injected directly into the fetus or the amniotic sac is capable of enhancing fetal lung maturity, a trial of thyroxine treatment in mean was carried out. Two hundred micrograms of T4 were injected intra-amniotically in eight women with high-risk pregnancies in which premature delivery was inevitable or indicated. Fetal lung maturity was evaluated by a recently developed, accurate, and rapid method using the microviscosity value epsilon (this being the linear expression of the polarization value P) of the lipid assembly of the amniotic fluid as a parameter of the surfactant content. epsilon Values, which were very high before T4 injection, dropped steeply to below the value of 4.344, indicating fetal lung maturity. Eight newborn infants delivered, five by caesarean section, soon after the T4 injection did not develop respiratory distress syndrome, although they were born prematurely. Intra-amniotic injection of T4 appears to be of therapeutic value in enhancing fetal lung maturity.

Amnion↗
PubMed1975

Congenital atrial flutter.

Two cases of congenital atrial flutter, one of which was documented electrocardiographically before birth, are reported. In both patients sinus rhythm was restored with digoxin treatment; in one patient the transition was preceded by various arrhythmias. No cardiac malformation was found in either case, and no materal disease occurred during pregnancy. Both mothers had received medication during pregnancy, but its role as a causative factor is questionable.

Atrial Flutter↗