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Biomedical subjects

M Brody

Publications and source records attributed to M Brody.

At least 19 recordsLinked to original sources
PubMed1997

Comparison of personal history with patch test results in metal allergy.

In order to compare the validity of patient personal history of contact sensitivity to metal alloys with patch test results, 160 patients with hand eczema were patch tested with a standard series according to the ICDRG after a special questionnaire. In 65%, history and patch test results were identical. Seventy-eight (48.8%) patients thought they would be allergic to metal ions, whereas the patch test revealed a positive result in only 21.3% cases. Positive history but negative test was more frequent in women; in the male group, negative history and positive patch test was the most common finding. Although 82 patients had a negative history, the patch test was positive for contact sensitivity to metal allergens in 12 of them. Both false positive patch tests and false negative histories are possible. Since many factors influence a positive patch test, not only the patient's history but also a synopsis of the anamnesis and patch testing will help to achieve the correct diagnosis of metal contact hypersensitivity.

Dermatitis, Allergic Contact↗
PubMed1996

Low back pain.

Explore the source record for details and available documents.

Emergency Medicine↗
PubMed1995

Expression of the genes encoding the rat renal insulin-like growth factor-I system.

Insulin-like growth factor-I (IGF-I) modulates renal function, growth, and repair. IGF-I produced in the kidney is one component of the intrarenal IGF-I system comprising the IGF-I receptor (IGF-IR) and six IGF-binding proteins (IGFBP). Because of the physiologic importance of IGF-I and its potential therapeutic properties, the renal sites of mRNA synthesis for IGF-I, IGF-IR, and IGFBP-I through IGFBP-5 were characterized in rat kidney by in situ hybridization. Anatomical heterogeneity was prominent. IGF-I mRNA was present in the thick ascending limb of Henle in the outer medulla, whereas IGF-IR mRNA was diffusely present at low levels throughout the kidney. IGFBP-I mRNA was localized to cells within the distal convoluted tubules as well as the thick ascending limb of Henle. IGFBP-2 mRNA was expressed in glomeruli, medullary ray collecting ducts, pelvic smooth muscle and uroepithelium, and the papilla tip; IGFBP-3 mRNA was localized to the cortical interstitium, whereas IGFBP-4 mRNA was expressed in proximal tubules, medullary ray collecting ducts, and glomeruli. IGFBP-5 was strongly positive throughout the medulla with lesser expression in the distal convoluted tubules and glomeruli. This study highlights the complexity of the intrarenal IGF-I system. The striking heterogeneity of IGFBP gene expression suggests that the various IGFBP may have diverse modulatory effects on the action of IGF-I or discrete effects of their own.

Animals↗
PubMed1994

[Successful treatment of panarteritis nodosa with low-dose methotrexate therapy].

We report on a 45-year-old male patient who presented a classic polyarteritis nodosa (PAN). The clinical course extended over 7 years. In spite of 2 years immunosuppressive therapy with azathioprine and methylprednisolone the course was progressive. Low-dose methotrexate therapy was the only treatment that controlled the disease, leading to rapid clinical and histopathological remission. In low concentrations methotrexate acts as an IL-1 inhibitor, and it obviously suppresses the pathogenetic mechanism of PAN.

Arteries↗
PubMed1994

Validation of a new instrument for determining migraine prevalence: the UCSD Migraine Questionnaire.

To provide a reliable instrument for use in large population surveys, we developed a short questionnaire based on existing International Headache Society diagnostic criteria and administered the questionnaire to 50 consecutive patients seeking evaluation at a university-based headache clinic. A single neurologist subsequently examined all patients. Based only on the questionnaires, reviewers scored each patient as having migraine with aura, migraine without aura, or nonmigrainous headache. High predictive validity and low interobserver variability between the examining neurologist and the independent reviewers suggest that the questionnaire may be quite useful as a survey instrument.

Adolescent↗
PubMed1993

Mechanism of action of methotrexate: experimental evidence that methotrexate blocks the binding of interleukin 1 beta to the interleukin 1 receptor on target cells.

Interleukin 1, a multifunctional cytokine, plays a central role in inflammatory processes and induction of the immune response. Target cells possess 200-5000 (or more) interleukin 1 receptors per cell, but they exhibit a full biological response when only 1-2% of these receptors are occupied by interleukin 1 alpha or 1 beta. Methotrexate has been reported to be beneficial in several inflammatory and autoimmune diseases. On the other hand, many of these diseases are known to share an overproduction of interleukin 1. It has been demonstrated that methotrexate has no influence on the interleukin 1 synthesis, so we focused our attention on the ability of methotrexate to interfere with the binding of interleukin 1 beta to the interleukin 1 receptor. The experiments were performed on monocytes, lymphocytes and granulocytes using a recombinant human cytokine probe. Methotrexate led to an astonishing decrease in the binding of interleukin 1 beta to the interleukin 1 receptor of peripheral blood cells, whereas methylprednisolone and indomethacin were not inhibitory. The inhibitory effect of methotrexate was dose dependent. An excess of interleukin 1 beta abolished the inhibition of cytokine binding by methotrexate. We also demonstrated that methotrexate does not affect the integrity of the interleukin 1 receptor or of the target cells. Our results demonstrate that methotrexate blocks the interleukin 1 beta-interleukin 1 receptor pathway. Methotrexate is therefore another interleukin 1 inhibitor and a clinically efficient anticytokine.

Flow Cytometry↗
PubMed1992

[Cold agglutinin syndrome after rubella infection].

Cold agglutinins are antibodies against erytrocyte membrane antigens, and are produced primarily or secondarily. We report on the case of a 5 year old girl who developed cold agglutinin disease 3 days after an attack of German measles. Following exposure to cold, appeared blue-red cutaneous manifestations of the fingers, hands cheeks and nose. The clinical manifestations cleared up without any specific therapy. The occurrence of cold agglutinins after German measles is rare. The case report is discussed within the context of reports in the literature.

Agglutinins↗
PubMed1989

Characterization of the relation between sodium channels and electrical activity in cultured rat skeletal myotubes: regulatory aspects.

The relation among sodium channel density, frequency of electrical activity and maximal rate of rise of the action potential was studied in developing and mature rat skeletal myotubes in culture. The number of tetrodotoxin (TTX)-sensitive Na-channels was determined by measurements of the amount of [3H]saxitoxin (STX) bound to the cultures, and electrical properties were recorded with intracellular microelectrodes. The EC50 for TTX-induced decreases in maximal STX-binding, frequency and rate of rise of action potentials was in the range 8-20 nM. The 3 variables increased in parallel with age in culture to reach peak values at age 7-8 days, and then decreased in parallel until 10-12 days in culture. The age-related increase in Na-channel density was decreased, but not abolished, by prevention of myoblast fusion. Treatment with the Ca2+ ionophore, A23187, down-regulated, and blockade of Ca-channels with verapamil up-regulated the number of Na-channels. Na-channel density was also increased by chronic treatment with TTX and elevated external [K+], which eliminated spontaneous electrical and contractile activity. Parallel effects were observed on frequency and rate of rise of action potentials. Up-regulation of Na-channels was prevented by simultaneous treatment of myotubes with inhibitors of protein synthesis. We conclude that electrical and mechanical activity of cultured myotubes regulate de novo synthesis of Na-channels through alterations in the level of cytosolic Ca2+.

Action Potentials↗
PubMed1986

Discharge planning for the mentally disabled.

Discharge planning is an idiosyncratic process that depends on each patient's needs and situation. Consequently, each mental health professional plays various roles as the process evolves. The most fundamental and pervasive issue in planning for the discharge and placement of the mentally ill patient is balancing the client's need for stability and security against the need for independence and unrestricted functioning. Although the needs and resources relevant to each individual situation must be analyzed, everyone requires some degree of continuity in his or her relationships and in such fundamental aspects of his or her life such as living arrangements and financial security, in order to function well. Stability and consistency are vital for the mentally disabled person, whose very illness is often characterized by severe difficulties with trusting, forming lasting relationships, and an inability to cope with frustrations and problems. Conversely, stability and consistency can translate into overdependence on others or a restricted view of the world that may contribute to overdependence. The discharge planner must maintain a reasonable degree of stability and consistency without totally extinguishing the spark that encourages the degree of risk taking necessary for a normal existence. The discharge planner will also be forced to deal with other issues such as public reactions to the mentally ill and fiscal constraints. The mentally ill have no real constituency to advocate for them; therefore, the services provided for them are often easy targets of a budget crunch. In addition, residences for the mentally ill are difficult to establish because of public attitudes and fears; often communities resist having one developed in their midst. Consequently, many residences are located in impoverished areas where clients are subjected to innumerable obstacles in attempting to live normal, productive lives. The discharge planner also may struggle with the discouragement of repeatedly placing the same patients. Many patients can manage community life for a limited time only before they decompensate and require read-mission, which starts the discharge planning process all over again. Other patients may learn to manipulate the system by getting readmitted when they want respite from the responsibilities of everyday life in the community. Community placement philosophy dictates that, assuming some measure of psychiatric stability, any time spent in the community as opposed to the hospital is advantageous to the patient. Thus readmission rates are not accurate indicators of success or failure in community placement.(ABSTRACT TRUNCATED AT 400 WORDS)

Adult↗
PubMed1983

In vitro release of immunoreactive substance P from putative afferent nerve endings in bovine pia arachnoid.

The release of substance P-like immunoreactivity was examined using bovine pia arachnoid and its attendant blood vessels in vitro. At concentrations of 20,51, and 100 mM, potassium ions evoked the release of substance P-like immunoreactivity in a dose-dependent manner. The drug capsaicin released substance P at concentrations greater than 10(-8) M. Both potassium- and capsaicin-induced release were abolished by omitting calcium ions from the superfusion buffer. When subjected to separation by reverse phase high performance liquid chromatography, the superfusate from capsaicin perfused tissues contained a peak of immunoreactivity which migrated at the retention time corresponding to substance P. During basal and stimulated states, the percent endogenous substance P released ranged between 0.4-6.5 X 10(-2) and 1.3-11.6 X 10(-2) per minute, rates comparable to those previously reported by others using slices of dorsal horn or spinal cord segments. The immunoreactivity measurable in the conditioned buffer probably reflected release from afferent nerve endings in as much as most of the substance P immunoreactivity in pia arachnoid arises from trigeminal ganglia. Release of substance P, a cerebrovasodilating peptide from perivascular nerve endings in pia arachnoid suggests a possible role for substance P in the pathophysiology of disorders associated with pain of cerebrovascular origin.

Animals↗
PubMed1980

Screening for congenital hypothyroidism in the Republic of Ireland.

A national pilot study for detecting congenital hypothyroidism by radioimmunoassay of thyroid-stimulating hormone concentrations in dried blood was incorporated into the newborn screening programme in Ireland on 1 August 1979. The programme has been monitored by a steering committee and follows the guidelines set by the European Society of Paediatric Endocrinologists. During the first 12 months 76 224 infants were screened and 19 cases confirmed, giving an incidence of 1:4012. Fifty infants (0.07%) were recalled for a serum sample, though most of the recalls (31; 0.04%) occurred during the first three months, before the methodology had become established. No case was detected clinically. At recall only three of the 19 affected infants had obvious features, and nine inconspicuous features. Organisation was directed at early diagnosis and treatment, the mean age at beginning treatment being 15 days. These results confirm the efficacy of screening for congenital hypothyroidism and suggest that capital and running costs will be offset by savings in maintenance treatment of untreated patients. Screening does not, however, remove the need for continued vigilance, and clinicians should request thyroid-function tests in any suspected case.

Age Factors↗
PubMed1979

Cerebrospinal fluid immunoglobulins in children.

Cerebrospinal fluid (CSF) immunoglobulins were measured in 62 normal children, in 9 children with purulent meningitis, and in 10 children with presumptive viral meningitis. The mean values in normal children were IgA 0, IgM 0, and IgG 0.84 +/- 1.4 mg/100 ml (+/- SD). The mean levels of all CSF immunoglobulins were raised in acute bacterial meningitis and were significantly greater than the levels found in viral meningitis. CSF IgM was 0.16 +/- 0.5 mg/100 ml in viral meningitis compared with 2.64 +/- 2.06 mg/100 ml in bacterial meningitis (P less than 0.01). However, these values overlapped to a considerable extent and, generally, measurement of CSF immunoglobulins did not enhance diagnostic accuracy in this group of children.

Cerebrospinal Fluid Proteins↗