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Biomedical subjects

M Bross

Publications and source records attributed to M Bross.

At least 19 recordsLinked to original sources

Emmert's law in the dark: active and passive proprioceptive effects on positive visual afterimages.

The relationship between apparent size and apparent distance is given by Emmert's law, which states that a retinal image is proportional in size to the distance of the surface it is projected upon. This principle also applies to retinal afterimages in that they, too, will change in apparent size if distance cues suggest that the location of the object onto the retinal image has been altered. It has also been known for some time that non-retinal cues can produce quantitative and qualitative effects on an afterimage when it is viewed in the dark. In the present two studies, positive afterimages of an observer's hand, as well as objects held by that hand, were used as targets to investigate the effects on size-constancy scaling of moving the hand to and fro along the line of sight for different distances in the dark. Results show that, when observers focus on a held object, the changes in size predicted by Emmert's law occur in response to both active and passive proprioceptive or haptic cues. The most intriguing result consisted of the finding that, when only the hand is the target, there appears to be a limit to the decrease in apparent hand size. It appears that the visual system 'refuses' to size-scale the hand below a limit it accepts as representative or acceptable of 'its' hand.

Adult↗

Strobilurin D and strobilurin F: two new cytostatic and antifungal (E)-beta-methoxyacrylate antibiotics from Cyphellopsis anomala (1).

Strobilurin D and strobilurin F, two new cytostatic and antifungal antibiotics of the (E)-beta-methoxyacrylate class, have been isolated from mycelial cultures of the basidiomycete Cyphellopsis anomala (Pers. ex Fr.) Sing. The structures were elucidated by spectroscopic methods. The antibiotics inhibit the growth of human and animal cells and a wide variety of fungi. Like strobilurins A and B, the new metabolites are potent inhibitors of respiration.

Animals↗

Antibiotics from basidiomycetes. XXXVII. New inhibitors of cholesterol biosynthesis from cultures of Xerula melanotricha Dörfelt.

Three new inhibitors of cholesterol biosynthesis have been isolated from cultures of Xerula melanotricha and their structures elucidated by spectroscopic methods. Dihydroxerulin (1) in admixture with xerulin (2) strongly inhibits the incorporation of 14C- acetate into cholesterol in HeLa cells while the incorporation of 14C-mevalonate is not affected. Xerulinic acid (3) shows similar biological activities but a higher cytotoxicity.

Agaricales↗

Asperfuran, a novel antifungal metabolite from Aspergillus oryzae.

Asperfuran is a novel antifungal dihydrobenzofuran derivative produced by a strain of Aspergillus oryzae. Asperfuran weakly inhibited chitin synthase from Coprinus cinereus. This inhibition could be abolished by the addition of egg lecithin. In the agar diffusion assay asperfuran induced morphological changes in Mucor miehei at very low concentrations (20 ng/disc) while growth was only partly inhibited. In HeLa S3 and L1210 cells it showed weak cytotoxicity, the IC50 was 25 micrograms/ml.

Antifungal Agents↗

Effect of monocular occlusion on rotary pursuit performance.

An experiment was conducted comparing a monocularly occluded to a control group (n = 8 per group) on a rotary pursuit task over a 24-hr. period. The results show that, notwithstanding a practice effect, the monocular group exhibited a significant depression-enhancement effect previously reported only for measures of temporal visual acuity. Evidently this effect generalizes to more complex tasks.

Adult↗

Effect of monocular occlusion on lateral phoria.

Several experiments have shown that monocular occlusion (MO) leads to a variety of changes in the visual functioning of the non-occluded eye. An experiment was conducted to assess the effect of 24 hr of MO on the lateral phoria, a binocular phenomenon. The results demonstrated marked tendencies for increased esophoria after MO, especially for near vision. Follow-up tests revealed that normal phoria was re-established 24 hr after the termination of MO. The results are discussed in the context of the use of MO in treatment procedures for visual dysfunctions and their implication for future investigations.

Accommodation, Ocular↗

Effect of subliminal visual material on an auditory signal detection task.

An experiment assessed the effect of subliminally embedded, visual material on an auditory detection task. 22 women and 19 men were presented tachistoscopically with words designated as "emotional" or "neutral" on the basis of prior GSRs and a Word Rating List under four conditions: (a) Unembedded Neutral, (b) Embedded Neutral, (c) Unembedded Emotional, and (d) Embedded Emotional. On each trial subjects made forced choices concerning the presence or absence of an auditory tone (1000 Hz) at threshold level; hits and false alarm rates were used to compute non-parametric indices for sensitivity (A') and response bias (B"). While over-all analyses of variance yielded no significant differences, further examination of the data suggests the presence of subliminally "receptive" and "non-receptive" subpopulations.

Adult↗

Temporal auditory acuity in blind and sighted subjects: a signal detection analysis.

Temporal auditory sensitivity was compared in five adventitiously blind and five normally sighted subjects in a signal-detection paradigm. Following determination of individual auditory flutter fusion (AFF) thresholds the subjects were required to make forced-choice responses between a fluttering and fused white noise under stimulus probabilities of 0.25, 0.50, and 0.75. From these data indices of sensory sensitivity (d') and response bias (Beta) were computed and compared. Analysis indicated no significant differences in auditory sensitivity between the two groups. These findings further weaken the traditional hypothesis of sensory compensation.

Adolescent↗

Visual effects of auditory deprivation: common intermodal and intramodal factors.

Visual temporal acuity, as measured by the critical flicker frequency decreased and then increased during 24 hours of auditory deprivation. This intermodal effect is similar to intramodal changes in the critical flicker frequency of the nonoccluded eye during monocular deprivation; a single mechanism appears to underlie both phenomena.

Adult↗

Signal detection analysis of visual flicker in deaf and hearing individuals.

A comparison of deaf and hearing subjects on temporal visual resolving power was conducted within a signal-detection paradigm. Subjects were required to make forced-choice judgments of a visual-flicker task under three stimulus probability conditions (0.25, 0.50, 0.75). A total of 600 trials were given each subject from which d' and Beta, indices for sensory sensitivity and response bias respectively, were computed. No significant differences existed on sensory sensitivity or response bias which questions some traditional assumptions about sensory compensation.

Adolescent↗

Residual sensory capacities of the deaf: a signal detection analysis of a visual discrimination task.

This experiment compared the visual sensory sensitivity of deaf and hearing subjects in a signal detection paradigm. Subjects (ns = 6) were required to give forced-choice responses to a brightness discrimination task under three stimulus probability conditions (0.25, 0.50, and 0.75). A total of 1,800 trials were given to each subject and utilized to construct isosensitivity functions and d' and Beta, indices for sensory sensitivity and response bias, respectively. The results showed that no enhanced sensory sensitivity is present for these deaf children and questions the classical sensory compensation hypothesis. Furthermore, the deaf subjects responded in a relatively bias-free manner to variations in stimulus probability.

Attention↗

Response bias in deaf and hearing subjects as a function of motivational factors.

This experiment assessed the effect of different payoff matrices on 6 deaf and 6 hearing subjects on a visual brightness discrimination task. Subjects were required to make forced-choice responses to three different monetary payoff conditions, designed to induce a liberal, a conservative, and an equal-bias response criterion, respectively. The results showed that the deaf did not select the superior response strategies they had exhibited in a previous study (Bross, 1979) on the effect of changes in stimulus probability. Furthermore, the deaf earned significantly less money than the controls for all three conditions, indicating that the introduction of motivational demands affects their response strategies adversely.

Child↗

Assimilation theory, attentive fields, and the Müller-Lyer illusion.

The assimilation theory of geometric illusions was employed to predict changes in the outgoing and ingoing forms of the Mûller-Lyer illusions as a function of attentive field size. It was found that the theory predicted correctly the form of the function relating amount of illusion and size of attentive field only for the outgoing Müller-Lyer. For the ingoing illusion the prediction was opposite to the empirically obtained results. The findings are seen as additional evidence for the untenability of a unitary theory, such as assimilation theory, for both versions of the Müller-Lyer illusion as they fail to account for substantial difference between them.

Female↗

Improvement of visual acuity in partially and fully sighted subjects as a function of practice, feedback, and instructional techniques.

Three experiments were conducted to examine improvement of partially (20/200 or 6/60) and normally (20/20 or 6/6) sighted adults. Measures of resolution and vernier acuity were examined in the first two experiments to determine whether practice, feedback, and instructions would have differential effects on the degree of visual improvement achieved in a 20-min. testing session. The results indicated extensive visual work to be the important factor in the improvement of impaired vision. The third experiment compared monocular and binocular depth perception of individuals with unilateral optic atrophy. The results yielded an unexpected finding where binocular depth perception was, in most cases, inferior to that of the strong eye alone. The first two experiments demonstrated the possibility of improving impaired visual functions and the third experiment suggests important implications for a theoretical model of depth perception with limited vision.

Depth Perception↗