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Biomedical subjects

M Bruhn

Publications and source records attributed to M Bruhn.

6 recordsLinked to original sources
PubMed2005

Immersion autometallographic tracing of zinc ions in Alzheimer beta-amyloid plaques.

An easy to perform autometallographic technique (AMG) for capturing zinc ions in Alzheimer plaques is presented. The possibility of visualizing loosely bound or free zinc ions in tissue by immersion autometallography (iZnS(AMG)) is a relatively recent development. The iZnS(AMG) staining is caused by zinc-sulphur nanocrystals created in 1-2 mm thick brain slices that are immersed in a 0.1% sodium sulphide, 3% glutaraldehyde phosphate buffered solution, the NeoTimm Solution (NTS), for 3 days. When the zinc-sulphur nanocrystals are subsequently silver-enhanced by autometallography, the plaques are readily identified as spheres of dark interlacing strands of different sizes, embedded in the pattern of zinc-enriched terminals. The zinc specificity of the iZnS(AMG) technique was tested by immersion of brain slides in the chelator DEDTC prior to the NTS immersion. The iZnS(AMG) detection of zinc ions is easily standardized and can be used in the quantification of plaques with stereological methods. This technique is the first to detect zinc in plaques in the cerebellum of transgenic PS1/APP mice and the first to detect zinc ions in plaques and dystrophic neurites at electron microscopical levels.

Aged↗
PubMed1991

Experiences with depression in a dementia clinic.

Of 317 consecutive cases seen in a dementia clinic, 19 (6%) had little or no objective evidence of cognitive impairment on clinical examination and extensive neuropsychological testing. Of the remaining 298 cases, 192 (64%) were diagnosed as probable or possible Alzheimer's disease (AD). Of the 19 nondemented cases, 8 (42%) were thought to have cognitive difficulty due to depression. In the AD group, only 4 cases (2%) were thought to be depressed and only 2 of the 4 met DSM-III-R criteria for major depression. There was no relationship between Hamilton Rating Scale for Depression scores and either cognitive or behavioral measurements of dementia severity, suggesting that the difference between the two groups was not due to underreporting by AD patients. The authors concluded that a tertiary care setting, depression is a common cause of cognitive complaints in persons without organic disease and a rare cause of excess morbidity in AD.

Adult↗
PubMed1987

Cutaneous alternariosis. Case report.

A case of cutaneous alternariosis is reported in the wife of a 73-year-old farmer. The diagnosis was verified culturally and histologically. The skin lesions were localized to legs, arms and face and were characterized by alternating spontaneous healing and formation of new lesions possibly due to autoinoculation from the lesions or re-exposure to the environment. The patient had a decreased resistance to infections owing to cancer - for which she had received X-ray treatment, chemotherapy and cortisone. This is the first reported Danish case.

Aged↗
PubMed1980

Working for women's health: The Women's Health Alliance of Long Island, Inc.

This article discusses the history of Long Island's feminist health organization, The Women's Health Alliance of Long Island, Inc. This community-based women's group was formed in 1975 by a group of educators, practitioners, students, and intersted laywomen who were concerned about health care for women in New York City and Long Island. Today, services include a major Women and Health conference held each spring, a feminist health education center, several smaller presentations for specific groups, and related projects. Through our history, we have faced difficult decisions regarding our functions, goals, and structure. This article addresses the means we have used to mediate these decisions in order to continue our programs and to open our voluntary agency, Healthouse, which functions as a resource and educational center for women.

Female↗