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Biomedical subjects

M Brzosko

Publications and source records attributed to M Brzosko.

9 recordsLinked to original sources
PubMed1997

Effects of ionic and non-ionic contrast media on platelet function as evaluated by plasma concentration of beta-thromboglobulin.

The aim of the study was to evaluate the effects of ionic and non-ionic contrast media on platelet function. In 44 patients who underwent angiography, the plasma concentration of beta-thromboglobulin (beta TG) was measured before and after ionic contrast medium (diatrizoate) administration in 22 patients and non-ionic contrast medium (iopromide) in the other 22 patients. A significant decrease in the plasma beta TG levels after intraarterial contrast medium injection occurred in both groups of patients. No significant beta TG level changes occurred in patients with normal pre-examination beta TG levels in both groups. In patients with elevated beta TG levels before arteriography, beta TG returned to normal values after contrast medium injection in both groups. There was no significant correlation between the amount of administered contrast medium and beta TG concentration after angiography. These results suggest that platelet function is not affected by either ionic or non-ionic contrast medium in patients with normal platelet activation. In patients with enhanced platelet activation, the activation became normal after contrast medium administration.

Adult↗
PubMed1997

[Backache and and related absenteeism].

The aim of this work was to compare the outcome of the questionnaire survey of low back pain with data on related sickness absenteeism. The questionnaire was responded by 585 (88.8%) employees. Of these number 288 (49.2%) respondents complained of low back pain. Sick leaves were given to 48 (16.7%) persons who had reported low back pains in the questionnaire and to 25 (8.4%) employees of 297 who had not reported the pain and also to 4 (5.4%) persons of 57 who had not responded to the questionnaire. Among those who had not complained of low back pain and were given sick leaves, mostly short ones, there were mainly men and blue collar workers. On the basis of our survey it seems that the analysis of sickness absenteeism due to low back pain does not completely reflect the prevalence of this disease, and that epidemiological studies of the prevalence should also take into consideration relevant sickness absenteeism.

Absenteeism↗
PubMed1995

[Gastrointestinal non-Hodgkin's lymphomas. Personal observations].

The localization, symptoms, endoscopic findings, histologic type, infiltration of bone marrow, lymphoma cell presence in the blood, and results of therapy were evaluated in 18 patients with gastrointestinal lymphoma. Only 9 patients met the criteria of primary gastrointestinal lymphoma, the remaining 9 presenting an extra-nodular localization of systemic disease, i.e. secondary lymphoma. The most common site of process was stomach, and most of the patients had histologically documented a high grade malignant lymphoma. Necessity of supplementing surgery with chemo- and/or radiotherapy was discussed. Such combined treatment should give a 10-year survival time in 60% of the treated patients (confirmed with the Kaplan-Meier's method). The authors concluded that stomach is the most common localization of gastrointestinal lymphoma, and that gastrointestinal non-Hodgkin's lymphoma diagnosis should include peripheral blood and bone marrow haematological examinations which clearly rise the reliability of differentiation between primary or secondary lymphomas.

Adult↗
PubMed1994

[Incidence of malignant lymphomas in Western Maritime Provinces in the years 1980-1984].

Incidence rate of malignant lymphomas was determined in the population of Western Pomerania region. The period of studies covered the years from 1980 to 1984 and the patients being over 14 years old. In the Western Pomerania region malignant lymphoma was diagnosed during that period in 528 subjects: low grade malignancy lymphomas were diagnosed in 268, therein lymphocytic lymphomas 135, with high grade malignancy 54: malignant granulomatosis 125 cases and 77 plasmocytic myelomas. The following data were taken into consideration: sex, place of residence, type of lymphoma: in case of malignant granulomatosis also the histopathologic subtype, and in multiple myeloma the type of monoclonal protein. Szczecin Voivodeship was found to have the highest incidence rate of malignant lymphoma, namely 9,1/10(5) of inhabitants: in Koszalin and Gorzów Voivodeships respectively 6.9/10(5) and 6.1/10(5) of inhabitants annually. The difference in the incidence rate in Szczecin Voivodeship and two other ones was significant (p < 0.001). No significant differences in the morbidity existed between Koszalin and Gorzów Voivodeships. In the region there was a preporderance of malignant lymphomas in relation to malignant granulomatosis. Morbidity in malignant lymphoma more frequently involved men than women. Morbidity rate of lymphoma with low and high malignancy, as well as plasmocytic myeloma increases with the age. On the other hand, in malignant granulomatosis no statistically significant differences depending on the age and sex were recorded. The incidence rate in respective groups of malignant lymphoma was the highest in Szczecin, followed by other towns in the region, being the lowest in rural environment. In our region, with regard to all malignant lymphomas, the disease is more frequently diagnosed in the advanced clinical stage.

Adult↗
PubMedDate not supplied

FC gamma RIIa polymorphism in patients with rheumatoid arthritis.

OBJECTIVE: Polymorphism of phagocyte IgG receptor Fc gamma RIIa may modulate immune complex mediated inflammation, particularly when immune complex contain IgG2. METHODS: Fc gamma RIIa genotyping in 82 patients with rheumatoid arthritis (RA) and 148 healthy subjects was performed using the polymerase chain reaction technique with allele specific primers. RESULTS: No significant relation between Fc gamma RIIa genotypes and susceptibility to RA was observed, but extraarticular complications with high frequency were revealed in patients with R/R131 genotype. CONCLUSION: The results suggest that the Fc gamma RIIa polymorphism is not a risk factor for RA.

Adolescent↗
PubMedDate not supplied

[Secondary malignant neoplasms in patients with non-Hodgkin's lymphoma].

In 1979-1987, 570 patients with non-Hodgkin's lymphomas (226 female and 344 male patients) were treated at the Department of Hematology of the Pomeranian Medical Academy and hematological outpatient clinic. The second malignant tumors were diagnosed in 25 (4.4%) patients. Two patients suffered from three malignant tumors. The most frequent combination of 2 tumors were: non-Hodgkin lymphoma and cancer of the lungs in 8 patients, non-Hodgkin lymphoma and cancer of the skin in 6 patients, non-Hodgkin lymphoma and cancer of the larynx in 4 patients, non-Hodgkin lymphoma combined with cancer of the stomach in 2 patients, and non-Hodgkin lymphoma together with cancer of the bladder in 2 patients. Moreover, non-Hodgkin lymphoma coexisted with cancer of the colon, cervix and prostate (one case of each). The authors stress the possibility of other malignant tumors in patients with non-Hodgkin lymphomas and occurrence of the subsequent neoplasms without preceding chemo- or radiotherapy.

Adult↗
PubMedDate not supplied

[Encephalopathy in the course of idiopathic hypereosinophilic syndrome -- clinical-morphological correlations].

A case of 33-year-old man, who underwent numerous hospital admissions caused by multiple progressing disseminated neurological abnormalities is presented. At first multiple sclerosis was a tentative diagnosis. Because of persistent eosinophilia, after exclusion of other causes of increased eosinophil count, idiopathic hyperoesinophilic syndrome was diagnosed. The case was confirmed neuropathologically. The authors discuss causes of idiopathic hyperoesinophilic syndrome. Very exceptional history of the syndrome, with dominant CNS involvement, is discussed.

Adult↗