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Biomedical subjects

M Buczek

Publications and source records attributed to M Buczek.

11 recordsLinked to original sources
PubMed1993

[Deep penetrating brain injury with 20 years of asymptomatic survival: a case report].

Authors report the case of penetrating injury of the head with large metallic fragment embedded to the brain with 20 years asymptomatic survival. Patient sustained head injury during work, 20 years ago and for these period of time was not aware of having foreign body intracranially with excellent general condition and no signs of neurological deficit. Metal nail was detected incidentally by plain skull X-ray films (and subsequent CT scan) during routine procedures when patient was admitted to the Laryngologic Dpt. for surgical procedure. In our opinion presented case in uncommon because of asymptomatic course. Most of penetrating head injuries are considered as life threatening due to sudden onset, severe general patient condition and possible deterioration according to the type of injury and extent of cerebral destruction. For those reasons earliest possible definitive neurosurgical treatment is recommended. We emphasize the role of debridement for most of brain penetration injuries.

Adult↗
PubMed1992

[Effect of metabolic stress on the release of glutamic acid and GABA in the brain tissue of Mongolian hamsters].

The concentrations of glutamic acid and GABA were determined in the brain tissue in gerbils under conditions simulating "metabolic stress", that is ischaemia, aglycaemia and anoxia. The material for the determinations was taken from fragments of the hippocampus incubated under these conditions in artificial cerebrospinal fluid, and the concentrations of these neurotransmitters were determined by histochemical methods in vitro. The release of glutamic acid and GABA into the extracellular space increased with longer duration of the incubation in a linear fashion in all experimental groups and was most pronounced in ischaemia. In case of calcium absence in the extracellular space inhibition was observed of the release of these neurotransmitters which suggested an important role of bivalent cations in the regulation of the studied process, especially under control conditions. During anoxia and ischaemia a considerable part of the release of glutamic acid and GABA seems to be calcium-independent which may suggest presence of additional sources of release of the amino acid neurotransmitters, apart from their release from the direct pool. It is possible that these sources are activated during metabolic stress involving nerve cells.

Animals↗
PubMed1992

[Metabolic effects of experimental thermal damage of the brain in rats--cold lesion].

Experimental thermal brain injury leads to significant reduction of glucose utilization in the damaged hemisphere particularly evident in the cortex 3 days after the injury. The rate of development of these changes is not parallel with the observed damage to the blood-brain barrier, coexistent brain oedema and slight disturbances of cerebral blood flow. In a series of experiments it was possible to demonstrate significant accumulation of glucose, high-energy phosphate compounds and their metabolites in the areas of the brain near the damaged part. The authors think that this is an evidence of reduced glucose uptake by the brain resulting from reduced energy needs of the damaged brain tissue despite sufficient supply of energy-yielding substances. Since cerebral metabolism and functions are in close interrelationship reduced glucose metabolism in the damaged tissue leads to reduced activity of the cortex, which contributes to transient (or permanent) functional neurological deficits observed after cranio-cerebral trauma in humans. The knowledge and understanding of these processes regulating the development of local depression of cerebral metabolic processes may help in better results of treatment in such cases.

Adenosine Triphosphate↗
PubMed1991

Effects of focal cortical freezing lesion on regional energy metabolism.

Freezing lesions have been shown to cause a depression in glucose use, particularly in cortical areas of the brain ipsilateral to the lesion, and this effect was interpreted to be caused by a depressed functional activity in these regions. The metabolic status of the affected areas has not been previously examined and could be a factor in the observed changes in local CMRglc. In frozen-cut and dried sections taken from brains 3 days after freeze lesioning, discrete pieces of the median and lateral parietal cortex, striatum, hippocampus, and hypothalamus were dissected and analyzed for ATP, P-creatine, glucose, and lactate. CMRglc measurements were also made in the same animals. The concentrations of the four metabolites were significantly increased in the lesioned hemisphere, with the most predominant effects observed in the cortical areas that exhibited the greatest depression in CMRglc. The enriched metabolite profile, particularly in the cortical areas, is consistent with the hypothesis that decreased glucose use in the traumatized brain is caused by diminished need rather than by decreased supply of energy. Because the lumped constant in the operational equation of the deoxyglucose method for determination of CMRglc is a function of brain glucose content and decreases gradually in hyperglycemia, the degree of metabolic depression in cortical areas of lesioned hemisphere probably have been somewhat overestimated in this and previous publications. However, provisionally recalculated local CMRglc in the lesioned hemisphere remain significantly lower than in the contralateral hemisphere and in the normal brain.

Adenosine Triphosphate↗
PubMed1989

[Conservative treatment of post-traumatic intracerebellar hematoma].

In previous years many authors stressed the very rare occurrence and difficulties in establishing of early diagnosis in cases of posttraumatic haematomas in the posterior cranial caeity, among them also the intracerebellar ones. The detection rate of this condition has increased greatly after introduction of computed tomography in the diagnosis of complications following craniocerebral trauma, changing also the view on the method of its treatment. Although before the introduction of CT the prevailin view was that all intracerebellar haematomas should be treated sugically the present opinion is that some of them meeting certain criteria (small size, peripheral situation in the cerebellar hemispheres laterally to the midline, absence of symptoms of intracranial hypertension, and the possibility of frequent CT control) may be treated successively without surgical intervention with adwantage to the patient. Two cases are presented in which intracerebellar haematomas were treated conserwatively. The authors review the pertinent literature stressing the criteria which should be considered in the qualification of patients for this management.

Adolescent↗
PubMedDate not supplied

The central nervous system in deaf adolescents.

Studies were made on 100 pupils, recruited from occupational rehabilitation schools for the deaf in Kraków. They underwent general medical as well as specialist examinations. Deafness was found up to the age of 3 years in 75% of those examined. In 30% of the subjects, their vestibular system was paralysed, ophthalmological disorders were found in 95% of cases, neurological disturbances in 15% and pathological changes of the central nervous system in 65% of cases were recorded by EEG. We did not look for evidence that deafness causes anatomical changes in the central nervous system, but the disturbances observed nevertheless indicate a correlation with congenital or early acquired deafness.

Adolescent↗
PubMedDate not supplied

[Post-traumatic cerebellar hematomas].

The authors present 16 cases of post-traumatic intracerebellar haematomas treated in the Department of Neurosurgery and the Division of Neurotraumatology, Chair of Neurosurgery, Medical Academy in Lódź in the years 1948-1987. The analysis included the type of trauma, the clinical course, the laboratory investigations and treatment methods. The following conclusions have been reached: Intracerebellar haematomas are post-traumatic complications of adult age following most frequency falls. On the basis of the clinical pattern it has not been possible to isolate a clinical syndrome characteristic for intracerebellar haematoma. A similar clinical course is observed in cases of other haematomas situated in other parts of the posterior cranial fossa. In the diagnosis of decisive importance is CT or operation. Mortality in intracerebellar haematomas is similar to that in epidural haematomas. Deaths occurred in cases operated on in acute stage. Owing to increasing availability of CT conservative treatment of intracerebellar haematomas has become possible. Follow-up shows that worse results of surgical treatment were obtained in cases of acute haematomas. In cases of chronic haematoma late results of treatment were good.

Acute Disease↗
PubMedDate not supplied

[A case of favorable outcome of conservative treatment of acute otogenic cerebellar abscess].

The authors report a case of conservatively cured abscess in the left cerebellar hemisphere demonstrated by CT. The patient was admitted in serious condition to a neurotraumatology centre. After pharmacological treatment a quick improvement of patient's health was achieved and control CT examination during his stay in hospital and after discharge from hospital confirmed the relation between clinical improvement and regression of changes in CT. The presented case points to the possibility of conservative treatment of brain abscesses if the patient meets certain clinical criteria, and CT provides the possibility of repeated checking of the dynamics of intracranial lesion.

Acute Disease↗
PubMedDate not supplied

[Diagnosis and treatment of central nervous system arachnoid cyst].

Arachnoid cysts of the CNS are uncommon lesions of considerable interest and importance, the origins and exact nature of which remain uncertain (congenital, posttraumatic, infectious or other). They form a well defined pathological entity and account for less than 1% of all CNS space-occupying lesions. Their membranous walls resemble slightly thickened arachnoid with CSF-like fluid. They are loosely attached to the dura mater and cerebral cortex, and are often adherent along the base of the skull or falx or located next to midline of the posterior fossa. A variety of clinical problems may be produced by such lesions depending on the location. The authors report five cases of arachnoid cysts diagnosed by CT and MRI. Four cysts were treated surgically (2 within posterior fossa, 2 spinal) and one intracellar cyst was treated conservatively. The value of CT and MRI in preoperative diagnosis and postoperative follow-up is emphasized and the symptomatology and choice of treatment are discussed.

Adult↗