Biomedical subjects
Publications and source records attributed to M Bursche.
The excretion capacity of 24 kidney allografts which had been dialyzed because of non-function was examined. It has been shown that only 4 out of 24 allografts (16.7%) were truly without function. All other transplants did show a slight or more improvement of the excretion capacity prior to irreversible loss of graft function. As a cause the non-identified graft rejection is discussed.
Twenty retransplant patients were serially screened for donor-reactive antibodies (DRA). DRA appeared exclusively in patients whose grafts permanently failed and these DRA shared some common features, namely early appearance (days 4-8 post-transplant), high titers (1:10 up to more than 1:400), and broad anti-HLA specificity. This preliminary data would suggest that regrafted patients with primary graft failure represent a distinct subgroup of particularly immune responsive individuals.