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Biomedical subjects

M Busch

Publications and source records attributed to M Busch.

At least 37 records · Page 2Linked to original sources
PubMed1990

Optimized afterloading therapy of cervix carcinoma with the discontinuous movement of the iridium source.

Optimization of brachytherapy means first of all a physical adaptation of isodoses to shape and tolerances of radiosensitive tissues surrounding the target volume, and also to shape and dosage requirements of the tumor to be treated. Dose computation algorithms for optimizing afterloading therapy postulate the discontinuous movement of the iridium source. A new method for the application of the discontinuous movement to our afterloading equipment was worked out. It combines the abilities of the source movements and the demands of the clinical optimization of the isodoses used for the brachytherapy of cervix carcinoma.

Brachytherapy↗
PubMed1990

[The disease picture of melorheostosis].

The rare syndrome of Lér's melorheostosis is described on the basis of a case encountered in one of our own patients, a 29 year old male patient. Particular attention is given to the symptoms, the specific results of clinical examination, and the differential diagnosis.

Adult↗
PubMed1989

Epidemiologic background of blood donors with antibody to human T-cell lymphotropic virus. Transfusion Safety Study Group.

We interviewed 51 blood donors in four major US metropolitan areas subsequently found to have had antibodies to human T-cell lymphotropic virus (anti-HTLV) in late 1984-early 1985. Sixteen donors (31%) reported that they or a sexual contact had a history of blood transfusion. Twelve donors (24%) reported that they or a sexual contact used intravenous drugs. Ten donors (20%) were blacks born in the southeastern US. Four of the male donors (15%) reported homosexual contact. The most common characteristic was an association with Japan or the Caribbean basin (61%). These results show a broader variation of epidemiologic backgrounds than anticipated.

Adult↗
PubMed1989

Direct methods for detection of HIV-1 infection.

The detection of human immunodeficiency virus type 1 (HIV-1) antibodies has proved to be a highly sensitive and specific means for the diagnosis of HIV-1 infection. Serologic methods have limitations in several specific clinical situations, however. In response to these problems, a wide variety of alternative diagnostic tests has been developed that detect infectious virus or structural components of the virus. All of the macromolecular constituents of HIV-1, DNA, RNA, and protein, have served as markers for the presence of the virus. In this article, we review the use of such direct methods and attempt to determine the likely place for each class of direct test in the diagnostic armamentarium.

AIDS Serodiagnosis↗
PubMed1988

Effects of interleukin 2 and large envelope glycoprotein (gp 120) of human immunodeficiency virus (HIV) on lymphocyte proliferative responses to cytomegalovirus.

Lymphocytes from many HIV-infected asymptomatic individuals or patients with AIDS-related conditions (ARC) and from all AIDS patients were unable to proliferate in vitro in response to UV-inactivated cytomegalovirus (CMV). The addition of recombinant IL2 (rIL2) restored proliferative responses of lymphocytes from most HIV-infected asymptomatic individuals and ARC patients to levels similar to those of HIV-seronegative (HIV-) CMV-seropositive (CMV+) individuals. In contrast, rIL2 augmented CMV-specific lymphocyte proliferation of only 33% (6/18) of AIDS patients. Proliferative responses to CMV with or without rIL2 did not correlate well with the levels of CD4+ lymphocytes, HIV antigen levels or ratios of CD4+ and CD8+ lymphocytes. Proliferative responses to CMV were inhibited by relatively high concentrations (greater than or equal to 10 micrograms/ml) of recombinant HIV envelope glycoprotein (rgp120) and this immunosuppression was completely overcome by rIL2. These results indicate that defects in antigen-driven lymphocyte responses of HIV-infected individuals are not simply the result of reduced numbers of CD4+ lymphocytes but are influenced by defects in IL2 pathways and by immunosuppressive effects of HIV gp120.

Acquired Immunodeficiency Syndrome↗
PubMed1988

[Recent application methods of high dose-rate brachytherapy in head and neck tumors].

A striking development has been made in intracavitary and interstitial brachytherapy of head and neck tumors by the use of very active and very small ray emitters and, last but not least, by the step movement of the source developed 1974 in Essen and its computer optimization. The present study mentions 22 different sites of the head and neck area which have been treated by 31 different intracavitary or interstitial techniques, frequently under general anaesthesia. All application methods used here follow uniform rules for the dosage of the single application. Furthermore, generally accepted rules can be defined for the contra-indications of brachytherapy which, according to our experiences, should be strictly observed. The observance of these rules as well as the use of a radiobiological gap were among the reasons for the complete recovery of some cases of local recurrence which could be no longer treated by other methods.

Brachytherapy↗