Biomedical subjects
Publications and source records attributed to M C BENNETT.
Methods of preparing liver for the microbiological assay of folic-acid activity have been compared. Maximum values were obtained by incubating an alkaline homogenate of liver in the presence of ascorbic acid for five hours at 37 degrees C. Most other procedures resulted in significant loss of folic-acid activity.
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Urinary excretion of urocanic acid and formimino-glutamic acid in abnormal amounts following oral doses of histidine has been observed not only in most cases of megaloblastic anaemia, but in iron-deficiency anaemia, haemolytic anaemia, and neoplastic disease. The urinary excretion of these substances is increased in those disease states in which an abnormally rapid rate of removal from the plasma of intravenously injected folic acid has been demonstrated.
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