[Controlling pain in renal transplantation].
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Humans↗
Biomedical subjects
M C Becq
Publications and source records attributed to M C Becq.
[Lumbar disk herniation with surgical option: general versus local anesthesia. Round table].
Lumbar disc hernia is a frequent pathology whose treatment remains essentially surgical. The type of anesthesia can be general anesthesia with intubation and controlled ventilation, both mandatory due to the position, peridural or spinal anesthesia. The usual position is knee-chest position which impairs circulation and ventilation if some precaution are not taken. Spinal anesthesia has been chosen in more than 40% of the patients by Lille CHU Team. This choice is justified by the important level of satisfaction of the patients and the absence of complications due to the anesthesia in a series of 1871 consecutive spinal anesthesia for lumbar disc surgery.
Adolescent↗
[Hemodynamic effects of genu-pectoral position during the surgery of lumbar disk herniation: spinal anesthesia versus general anesthesia].
Spinal anesthesia (SA) for lumbar disk surgery in the genu-pectoral position (GP) has been proposed as an alternative to general anesthesia (GA). This study compares the haemodynamic effects of GP in two groups of patients undergoing either SA (n = 43) or GA (n = 40). Mean arterial pressure (MAP) and heart rate (HR) were recorded before and after GP. MAP and HR were significantly lower in the GA group after GP. We conclude that SA during GP for lumbar disk surgery is haemodynamically well tolerated.
Adult↗
[TNF and sepsis].
Recent experiments have demonstrated that TNF plays an important role in the pathogenesis of septic shock. To confirm the involvement of TNF in human septic shock, serum TNF levels were measured in 10 adult patients admitted to the intensive care unit for sepsis with or without shock. Septic shock was corroborated by hemodynamic data (right catheterization, measurement of cardiac output by thermodilution). For TNF measurement, venous blood samples were withdrawn, as soon as possible after the onset of sepsis, into a pyrogen--free tube. Serum TNF levels were determined using a radioimmunoenzymatic assay (IRE Medgenix). During septic shock (n = 7), TNF levels were significantly higher (m = 354 +/- 131 pg/ml) than during sepsis without shock (n = 8; m = 145 +/- 35 pg/ml) (p less than 0.0005). TNF levels were also significantly higher in non-survivors (m = 392 +/- 111 pg/ml) than in survivors (m = 167 +/- 81 pg/ml) (p less than 0.0005). The value of 250 pg/ml seems to be critical: no patient without shock had TNF levels above 250 and all the patients who died early during the first 24 h) had TNF levels above 250. The TNF level is negatively correlated with the platelet count (r = -0.70; p less than 0.05). These data favor a pathophysiological for TNF in human sepsis and septic shock.
Adolescent↗
[Cachectin in septic states].
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Adolescent↗
Effect of propofol on the malignant hyperthermia susceptible pig model.
Anaesthetic techniques for malignant hyperthermia susceptible (MHS) patients should include drugs which do not trigger MH and provide stress free conditions. Thus all new drugs should be screened for their susceptibility to trigger MH. We have screened propofol, using the MHS pig model. In none of the animals exposed to propofol, were there signs of MH, even after challenge with suxamethonium. However, the same animals developed MH when exposed to halothane alone or with suxamethonium. Despite the problems of extrapolating from this study to man, it is unlikely that propofol may trigger an episode of MH.
Anesthetics↗