Biomedical subjects

M C Coordt

Publications and source records attributed to M C Coordt.

2 recordsLinked to original sources

PubMed1996

Effects of caloric restriction and source of dietary carbohydrate on glycemic status of the Fischer 344 rat.

The effects of caloric restriction and dietary carbohydrate source on the regulation of insulin secretion were evaluated in vivo and using islets of Langerhans isolated from 9-month-old male Fischer 344 rats. Serum glucose and insulin concentrations of rats fed a calorie-restricted diet for 6 months were significantly less than those of rats fed ad libitum, regardless of carbohydrate source. Rats fed diets containing fructose, either as a monosaccharide or as a component of a disaccharide, had generally greater serum insulin and glucose concentrations than rats fed diets containing no fructose. Glucose-stimulated insulin secretion by islets isolated from rats fed the restricted diet was significantly less than those of rats fed ad libitum. No differences in islet insulin secretion associated with carbohydrate source were observed. These results suggest that caloric restriction and the source of dietary carbohydrate can have significant effects on the glycemic status of the rat.

Animals↗

PubMed1995

Aging and insulin secretion.

Aging in mammals has often been associated with decreased insulin secretion and a subsequent deterioration in the ability to maintain glucose homeostasis. However, recent studies have demonstrated that factors such as disease, obesity, and physical activity more closely reflect diminished insulin secretion rather than aging per se. Thus, the purpose of this article is to review recent studies of how biological aging, i.e. the process independent of disease states such as type II diabetes, may affect insulin secretion. To this end, this review will address the impact of aging on insulin secretion in terms of in vivo and in vitro assessment, as well as possible age-related alterations in the hormonal and neural regulation of insulin secretion. Finally, this review describes some evidence that alterations in the functional heterogeneity of the beta-cell population may represent a means by which the endocrine pancreas is able to maintain appropriate insulin secretion during senescence.

Aging↗