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Biomedical subjects

M C Flannery

Publications and source records attributed to M C Flannery.

11 recordsLinked to original sources
PubMed1997

Calcium alginate as haemostatic swabs in hip fracture surgery.

Blood loss as a consequence of internal fixation of intertrochanteric fractures of the proximal femur was measured in two groups to compare the haemostatic effect of calcium alginate fibre swabs with that of simple gauze swabs. The patients in the gauze swab group lost 139.4 +/- 9.6 mL per-operatively, whilst those in the alginate swab group lost 98.8 +/- 9.9 mL (P < 0.01). The post-operative suction drainage loss in the gauze group was 158.4 +/- 17.3 mL, and that in the alginate swab group was 96.6 +/- 11.7 mL (P < 0.01). This study shows that alginate swabs significantly decrease per-operative blood loss and post-operative suction drainage loss, and suggests that haemostatic swabs could have wider applications in orthopaedic surgery.

Aged↗
PubMed1992

Fractures of the distal clavicle: a case for fixation.

We present a series of 43 Neer type 2 fractures of the distal one-third of the clavicle. These displaced fractures are associated with a high incidence of non-union. In those patients treated non-operatively there was a higher incidence of local complications, residual shoulder dysfunction and non-union than in those treated by open reduction and internal fixation. We recommend that type 2 fractures should be treated by open reduction and internal fixation.

Adolescent↗
PubMed1983

Dose-response curve analysis of gastric secretory responses in the dog and man to impromidine: a new histamine-H2-receptor agonist.

The new histamine-H2-receptor agonist, impromidine, was assessed for its effect on gastric acid secretion using a dose-response format. Maximal acid output and ED50 were calculated for infusions of impromidine in the Heidenhain pouch dog (0.05-1.6 x 10(-8) mol/kg/hr) and in man (0.39-6.22 x 10(-8) mol/kg/hr). Analysis of the responses was carried out by nonlinear regression using the logistic function. This allowed the data to be analyzed without making assumptions about the steepness of the curve which in man was almost twice that found in the dog (1.8:1). The ED50 in the dog was 0.26 +/- 0.029 x 10(-8) mol/kg/hr. The control dose-responses could be inhibited in a competitive manner by histamine-H2-receptor antagonists. Analysis of the control curve and three curves in the presence of increasing doses of antagonist was carried out by fitting all the curves simultaneously to calculate an in vivo ID50. In the dog, the antagonist was tiotidine (0.05, 0.1 and 0.2 x 10(-6) mol/kg/hr) and the ID50 was 0.012 +/- 0.002 x 10(-6) mol/kg/hr. In man, cimetidine (1.05, 2.10 and 4.2 x 10(-6) mol/kg/hr) was used to inhibit secretion. The calculated ID50 was 0.63 +/- 0.085 x 10(-6) mol/kg/hr. Comparison of the effect of cimetidine and tiotidine against both impromidine and histamine showed that the ID50 was the same for both stimulants. Impromidine proved to be a potent stimulant of gastric acid secretion acting via the H2-receptor to produce readily definable dose-response curves in the dog and in man.

Adult↗
PubMed1982

Gastric acid secretion induced by impromidine in the dog and man: analysis of dose-response relationships.

The new histamine H2-receptor agonist, impromidine, was used to assess three models of dose-response curves in vivo. Vm and ED50 values were calculated for gastric acid output to infusions of impromidine in the dog with a Heidenhain pouch and in man. In two models Michaelis-Menten kinetics were assumed: the linear transformation using the Eadie-Hofstee plot and the non-linear hyperbola, but in the third method the logistic function allowed the data to be analysed without making assumptions about the steepness of the curves. In the dog all three models gave similar results both for calculated Vm and ED50. Curve steepness from the logistic function was found to be 0.98 +/- 0.023 - not different from that assumed for the hyperbola (where steepness = 1). The results in man were different: the Eadie-Hofstee plot did not produce a significantly linear fit while the logistic function produced the smallest standard errors. The logistic curve slope was almost twice that assumed for the hyperbola (1.8 : 1) and it seems, therefore, that impromidine-induced gastric acid secretion does not follow Michaelis-Menten kinetics in man and data should be analysed using methods which allow the calculation of curve steepness.

Animals↗