Ocular hypertensive response to dexamethasone.
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Administration, Topical↗
Biomedical subjects
M C Hagan
Publications and source records attributed to M C Hagan.
The lens in hereditary hyperferritinaemia cataract syndrome contains crystalline deposits of L-ferritin.
BACKGROUND/AIM: Hereditary hyperferritinaemia cataract syndrome (HHCS) is an autosomal dominant disorder characterised by elevated serum L-ferritin and bilateral cataracts. The ocular manifestations of this disorder are poorly studied. This study therefore sought to determine the origin of cataracts in HHCS. METHODS: L-ferritin ELISA, immunohistochemical and ultrastructural analysis of a lens nucleus from an HHCS individual. RESULTS: The HHCS lens L-ferritin content was 147 microg/g dry weight of lens compared with <16 microg/g for a non-HHCS control cataract lens. The cataract comprised discrete crystalline inclusions with positive staining with anti-L-ferritin but not anti-H-ferritin. CONCLUSIONS: This unusual finding of crystalline opacities in the lens may be unique to HHCS and is likely to result from disturbed metabolism of L-ferritin within the lens or an abnormal interaction between L-ferritin and lens proteins.
Animals↗
Day case strabismus surgery without post-operative ocular medication. A masked randomised study.
A masked, randomised study was designed to test the hypothesis that day case strabismus surgery and the absence of post-operative topical medication is a plan of management that does not compare unfavourably with discharge from hospital on the day after surgery with topical antibiotic and anti-inflammatory therapy for 14 days. The results indicate that patients who have day case surgery do not have more complications than overnight stay patients and that their inflammation and discomfort settle just as quickly without topical therapy. Medical, social and financial benefits of day case surgery are noted.
Ambulatory Surgical Procedures↗