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Biomedical subjects

M C Meyer

Publications and source records attributed to M C Meyer.

At least 91 records · Page 5Linked to original sources
PubMed1976

Bioavailability of 17 ampicillin products.

The bioavailability of single lots of 250-mg ampicillin capsules, available from 17 distributors and/or manufactures, was determined. Each product was evaluated in terms of the serum ampicillin levels achieved at 1, 2, 3, 4, 6, and 8 hr postadministration, the peak serum levels, the time of peak serum level, and the area under the serum level-time curve. There was no statistically significant difference (p is greater than 0.05) between any of the 17 products tested.

Adult↗
PubMed1976

Bioavailability of 11 sulfisoxazole products in humans.

Single lots of 11 commercially available 500-mg sulfisoxazole tablets were evaluated in vitro and in vivo. All products tested met USP XVIII specifications for weight variation and product assay. However, three products failed to meet the USP XVIII dissolution requirement. The only statistically significant difference observed between the 11 products was a lower peak plasma level exhibited by one product. No useful correlation was observed between the in vivo and in vitro studies for the dosage forms tested.

Adult↗
PubMed1976

Hydrochlorothiazide.

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Biological Availability↗
PubMed1975

Folic acid dosage for chronic hemodialysis patients.

The doses of folic acid, necessary to avoid folic acid deficiency in patients being maintained on hemodialysis, have been estimated to be between 1 and 5 mg daily. To more precisely define an adequate dose of folic acid, 6 anephric patients were studied. The patients were maintained on hemodialysis and received, in a crossover fashion, 1 mg and 5 mg of folic acid for 3 wk. In a second crossover study, 3 anephric patients were first maintained on 0 and then on 1 mg of folic acid after each dialysis for 3 wk periods. Pre- and postdialysis folic acid blood levels were measured and dialyzer clearances of folic acid were determined. The results of this study support the conclusion of the Food and Drug Administration report suggesting that daily doses of 1 mg of folic acid are adequate to sustain therapeutic folate levels. The data further indicate that the administration of 1 mg of folic acid after each dialysis, rather than 1 mg of folic acid daily, can provide adequate folate.

Administration, Oral↗
PubMed1974

Rapid, precise, turbidometric assay for low levels of ampicillin in serum after single-dose oral administration.

A turbidometric assay is described for the quantitative measurement of ampicillin in serum. Standard curves prepared with known concentrations of ampicillin in serum exhibited acceptable linearity over a concentration range of approximately 0.2 to 1.8 mug/ml. Data are presented to show the excellent precision of the assay and the application of the assay to clinical studies. The advantages of this method over other procedures are discussed. Because of the questionable stability of ampicillin, samples containing known concentrations of ampicillin in serum were assayed after storage for various lengths of time. Serum samples maintained in the frozen state until the time of assay exhibited approximately 12% degradation after 7 days, whereas those samples which were subjected to repeated thawing and refreezing exhibited approximately 25% degradation after the same time interval.

Administration, Oral↗