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Biomedical subjects

M C Ormiston

Publications and source records attributed to M C Ormiston.

12 recordsLinked to original sources
PubMed1985

Controlled trial of Iodosorb in chronic venous ulcers.

Cadexomer iodine (Iodosorb) is a hydrophilic starch powder containing iodine, which is a suitable dressing for granulating wounds such as venous ulcers. A total of 61 outpatients with chronic venous ulcers participated in a randomised optional crossover trial using cadexomer iodine or a standard dressing for their ulcers. The trial lasted for 24 weeks or until the ulcer had healed. Two patients withdrew during the course of the trial. Both treatments were highly effective, but the epithelium of ulcers dressed with cadexomer iodine grew again significantly faster (p less than 0.001). At the midpoint of the trial (12th week) 13 of 30 patients receiving standard treatment were changed to cadexomer iodine, while only three of 29 receiving cadexomer iodine changed to the standard dressing (p less than 0.02). In most cases ulcers were dressed and rebandaged daily by the patients themselves after instruction and supervision. This may be better than having dressings and bandages applied by professionals less regularly.

Adult↗
PubMed1985

A study of rat intestinal wound healing in the presence of radiation injury.

Anastomotic dehiscence is a common complication following the resection of intestine with late radiation damage, and can occur even after wide resection of obviously compromised tissue. In this study using male rats, exteriorized segments of terminal ileum and/or the fatty appendages of the testes were exposed to single doses of irradiation (10, 15 and 20 Gy) producing early and late damage of varying severity. Wounds made at intervals from 2-24 weeks after irradiation in normal or irradiated ileum were repaired immediately and wrapped in normal or irradiated appendages. Post mortem examination of the wounds 4-7 days later showed that, in general, control wounds made in unirradiated tissues healed soundly. The incidence of wound breakdown in irradiated tissues was dose-dependent. After irradiation of the ileum alone, the frequency of suture line dehiscence increased with the interval between irradiation and wounding. When the ileum and appendages or appendages alone had been irradiated, the frequency of dehiscence was increased from 2 weeks post-irradiation onwards. This study emphasizes the important role played by adhesions in rat intestinal wound healing and shows that dehiscence may occur if irradiated tissues are positioned next to a suture line made in normal rat intestine. The findings suggest that, in clinical practice, it may be advisable to ensure that anastomoses at risk from radiation damage area wrapped in unirradiated tissue such as omentum.

Animals↗
PubMed1985

Is follow up of patients after surgery for breast cancer worthwhile?

The effectiveness of routine outpatient follow up in detecting recurrent disease after 'curative' surgery for breast cancer has been evaluated in a retrospective study of 148 patients. In all, 32 patients developed recurrent cancer. In 3 cases, asymptomatic disease was discovered by routine X-rays. In 25 cases, the patient noticed local disease or complained of symptoms due to distant spread, and over half of these returned to the clinic before the next routine appointment. In only 4 cases was routine examination by a doctor solely responsible for the discovery of recurrent disease. It is concluded that routine follow up made little contribution to the welfare of these patients.

Bone Neoplasms↗
PubMed1982

Urothelial abnormalities in the obstructed bladder.

Bladder mucosa from patients undergoing prostatectomy was examined histologically for evidence of pre-malignant change. The mucosal appearances were compared with tissue taken from control patients without bladder outlet obstruction. The appearances in patients with uncomplicated obstruction and in control patients were found to be similar and dysplastic change was uncommon. However, dysplasia was found relatively frequently in patients with bladder outlet obstruction complicated by the presence of infection, catheters or stones. In all, 10 out of 74 patients were found to have dysplasia and 7 of these agreed to have a further cystoscopy and biopsy taken at an interval of between 10 and 28 months after the first examination. Persistent dysplasia was found in all 7 cases and in 3 of these it had progressed from mild to moderate in severity. The significance of these findings is discussed.

Adult↗
PubMed1982

Five year follow-up study of gastritis.

This paper describes a five year follow-up study of the incidence and course of gastritis affecting the antrum and body of the stomach of 50 patients, most of whom presented with non-ulcer dyspepsia and a few with peptic ulceration. We have shown that antral gastritis, like gastritis affecting the fundus, becomes more severe in a proportion of patients as time goes by. Perhaps more important is the increased severity and progression of atrophic and metaplastic change in the antrum compared with the fundus. The significance of these changes with regard to the development of peptic ulceration and malignancy is discussed.

Adult↗