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M C Pinto

Publications and source records attributed to M C Pinto.

38 records · Page 3Linked to original sources

Severely injured patients in the intensive care unit: a critical analysis of outcome and unexpected deaths identified by the TRISS methodology.

An analysis of the factors related to the morbidity and mortality of 64 patients sustaining abdominal trauma requiring intensive care during the postoperative period, and an evaluation of the unexpected deaths based on trauma indices was carried out to identify factors that could have contributed to the observed outcome. Head and chest injuries occurred in approximately 40% of all patients. Pneumonia was the most common complication. ISS (p = 0.03), but not TS was statistically significant as predictor of outcome. Probability of survival (TRISS) was 62.4 +/- 4.2%, while observed overall survival rate was 54.7%. Multivariate analysis identified age greater than 45 years (p = 0.02; RR = 2.5) and ISS greater than 20 (p = 0.03; RR = 4.0) as the most predictive factors for systemic complications. Mortality was directly influenced by age greater than 45 years (p = 0.05; RR = 2.4) and by the presence of a systemic complication (p = 0.003; RR = 5.5). Eleven patients were classified as "unexpected death"; 5 were considered preventable, 3 non preventable, 1 potentially preventable, and 2 cases had incomplete data and could not be classified. Changes in the care of the severely injured due to a review of complications and deaths may ultimately lead to a reduction in errors and a better quality of care.

Abdominal Injuries↗

[Gene amplification in bladder tumors].

Eight patients with transitional cell bladder carcinoma were analyzed viewing the detection of ras oncogene mutations. This sample was picked out from a preliminary study of 20 cases of transitional cell tumors where complex chromosomal rearrangements were observed in tumors of grade II/III. In this first stage of the study non invasive tumors presented an almost diploid chromosome number while the most infiltrative ones displayed pseudo triploidy, triploidy or tetraploidy. A Subsequent study searched for the mutational frequency of the oncogene n-ras using the knowledge of direct DN sequencing and based on the technology of polymerase chain reaction amplification (PCR) in view to establish a relationship between the mutational frequency and the tumor stage and grade. The wild type allele was present in all the tumors examined. Point mutations were detected in 1/3 of the analyzed samples. These samples displayed a grade II-III histology as opposed to the other tumors. These data appear to indicate that n-ras mutations may be early phenomena in the development and progress of a number of human tumors of the urothelium.

Aged↗