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M C Shen

Publications and source records attributed to M C Shen.

At least 91 records · Page 5Linked to original sources
PubMed1984

Anti-HTLV antibodies in cancer patients, hemophiliacs and uremics: a preliminary report.

A total of 132 sera were studied for anti-HTLV antibodies using the Biotech ELISA test. Among the HTL group, two were, one, and the other two (+/-). Among 23 hemophiliacs one was. None of the lympho- and myelo-proliferative disorders, chronic uremics and normal controls showed positive results. Our results show that the ELISA anti-HTLV test is quite specific for HTL and related disorders, but the antibody titers may be low in some cases in the late stage. The significance of frequent high ELISA readings in hepatomas and NPCs awaits for further studies. The occurrence of one hemophiliac with definite positive anti-HTLV calls for a routine screening of the blood preparations for HTLV.

Acquired Immunodeficiency Syndrome↗
PubMed1982

A comparative study of carrier detection in haemophilia A by linear discriminant function.

Blood samples collected from 37 definite carriers, 31 normal women and 64 possible carriers were examined for factor VIII-related activities. Five variables: factor VIII coagulant activity (VIII:C) (X1), factor VIII-related antigen (VIIIR:Ag) (X2), ristocetin co-factor (VIIIR:RC) (X3), ratio of VIIIR:Ag to VIII:C (A/C) (X4) and ratio of VIII:RC to VIII:C (R/C) (X5), and 28 combinations of one to five variables were used to derive 28 linear discriminant functions. The calculation of discriminant function coefficient, individual discriminant score and cut-off point, and the identification of normals or carriers were processed by the computer package of a biomedical computer program used at University of California at Los Angeles. A comparison of 28 linear discriminant functions for carrier detection in haemophilia A has indicated that the best and simplest is y = 0.11668X1 (VIII:C)--0.06042X2 (VIIIR:Ag), (cut-off point y = 2.03742). It identified 94.6% of carriers without a single misclassification in the normal group, and the overall identification rate was 97.1%. Of 29 daughters of definite carriers who had no haemophilic sons, 13, or 44.8%, could be identified as carriers. It was found that VIII:RC was not as good as VIIIR:Ag for carrier detection; however, it may be concluded from this study that VIIIR:RC can be used as a supplement, if not a substitute, for VIII:Ag in the carrier detection of haemophilia A.

Adolescent↗