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Biomedical subjects

M C Turner

Publications and source records attributed to M C Turner.

12 recordsLinked to original sources
PubMed1992

The perioperative management of pheochromocytoma in children.

The perioperative experiences of 15 children and adolescents who underwent a total of 18 surgical procedures for resection of a pheochromocytoma were analyzed to determine clinical or hemodynamic events associated with intraoperative or postoperative complications. Of the pre- and intraoperative factors assessed, only preoperative resolution of symptoms and normalization of blood pressure were predictive of uncomplicated outcome. No intraoperative factors were statistically associated with outcome, but the four patients with complicated outcomes had had aggressively administered intraoperative fluids. Noninvasive measures of cardiac function did not help predict outcome; however, echocardiography results were available only for six patients. Two of the patients with complicated outcomes had cardiac dysfunction, suggesting undiagnosed catecholamine-induced cardiomyopathy in the other two with complicated outcomes. Intraoperative fluids should be given based on intraoperative blood pressures, the presence or absence of prior adrenergic blockade, and assessment of preoperative myocardial function. If preoperative myocardial dysfunction is revealed, intraoperative measurement of right atrial and pulmonary capillary wedge pressures may be indicated.

Adolescent↗
PubMed1990

Low-dose ciclosporin, prednisone, and azathioprine after initial immunosuppression with ciclosporin and prednisone in a pediatric renal transplant population.

The use of a triple therapy regimen after initial immunosuppression with prednisone and ciclosporin in the pediatric age groups has not been described. Twenty-two patients were switched to low-dose ciclosporin, prednisone, and azathioprine due to toxicity, noncompliance, and long-term ciclosporin treatment. The acute rejection rate was 13.5%; one graft was lost to irreversible rejection. No infections occurred. There was no difference in the frequency of return to dialysis in the group converted to triple therapy when compared to a control group remaining on double therapy with prednisone and ciclosporin. The efficacy and safety of changing immunosuppression in the pediatric age group needs to be confirmed in a prospective, randomized fashion.

Actuarial Analysis↗
PubMed1987

Multicentric osteolysis: report of the second successful renal transplant.

A patient with end stage renal disease due to sporadic idiopathic multicentric osteolysis (type 3 multicentric osteolysis) is described. His pre-transplant course was similar to those of previously described patients, while his post-transplant course has been uncomplicated. The pathology and pathogenesis of the nephropathy of sporadic idiopathic multicentric osteolysis is not well characterized. The short term outcome of renal transplantation is excellent in our patient and in the other similar case known to have been transplanted.

Adolescent↗
PubMed1986

Childhood familial pheochromocytoma. Conflicting results of localization techniques.

Childhood familial pheochromocytoma was investigated in four patients by abdominal computed tomographic scan, [131I]metaiodobenzylguanidine scan, and vena caval catecholamine sampling. Results conflicted with surgical findings. Computed tomographic scan identified all four adrenal tumors but missed two midline tumors in one patient. [131I]metaiodobenzylguanidine scan identified two of three adrenal tumors but also suggested extra-adrenal tumors not confirmed at operation in two of three patients. Vena caval sampling for catecholamines confirmed all adrenal tumors but suggested additional tumors not verified at operation in two of three patients. All patients are asymptomatic and have normal urinary catecholamines 15 to 51 months after operation. Because of the frequency of multiple tumors in familial pheochromocytoma, different diagnostic techniques were employed. False-positive results were more frequent with [131I]metaiodobenzylguanidine and vena caval sampling. Reinterpretation of the [131I]metaiodobenzylguanidine scans at a later date led to less false-positive interpretation, although the false-negative rate remained unchanged. More pediatric experience with [131I]metaiodobenzylguanidine scans and vena caval sampling in familial pheochromocytoma is needed. Confirmation of tumor and its localization rest with meticulous surgical exploration.

3-Iodobenzylguanidine↗
PubMed1979

Unusual ultrastructural features in a case of acute diffuse proliferative glomerulonephritis.

A case consistent with recurrent acute poststreptococcal glomerulonephritis but with atypical features is described. Light microscopy revealed a diffuse proliferative glomerulonephritis. A spectrum of ultrastructural features, from the typical "humpy bumpy" subepithelial deposits to the apparent disappearance of the deposits within the epithelial cells, is presented. An unusual piling up of basement membrane material around the deposits is described, together with some areas showing an appearance reminiscent of membranous glomerulopathy. Resorption of the dense deposits within epithelial cells is suggested and a hypothesis advanced that the basement membrane reaction may indicate an incipient chronic immune complex lesion.

Acute Disease↗
PubMed1977

Deformed kittens.

Explore the source record for details and available documents.

Abnormalities, Drug-Induced↗
PubMed1977

Renal failure as a presenting sign of diffuse sarcoidosis in an adolescent girl.

We report a renal failure due to sarcoid granulomatous infiltration of the kidney that was documented by renal biopsy in an adolescent black albino girl. Treatment with prednisone was associated with improvement in the clinical disease and the histologic picture on repeat biopsy. With cessation of prednisone there was clinical and histological relapse while reinstitution of prednisone therapy was again associated with improvement. Experience with this child, as well as that reported previously in seven similar adult patients, would indicate that prednisone is an effective drug to control this unusual problem.

Acute Kidney Injury↗