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Biomedical subjects

M C Wan

Publications and source records attributed to M C Wan.

4 recordsLinked to original sources
PubMed2001

Ankle brachial pressure index in systemic sclerosis: influence of disease subtype and anticentromere antibody.

OBJECTIVE: To test the hypothesis that patients with limited cutaneous systemic sclerosis (SSc) have a higher incidence of lower limb large vessel disease than patients with diffuse cutaneous disease, and that anticentromere antibody is a risk factor for lower limb large vessel disease. METHODS: Clinical and laboratory data from 119 patients with SSc (91 patients with limited cutaneous disease, 28 patients with diffuse cutaneous disease) who had bilateral ankle brachial pressure indices (ABPI) measured between March 1997 and January 2000 were reviewed retrospectively. RESULTS: There was no evidence of reduced ABPI in limited cutaneous disease (P=0.65), average reduction 0.01 [95% confidence interval (CI) -0.04 to +0.07]. There was some suggestion of reduced ABPI in anticentromere-positive patients (P=0.12), average reduction 0.04 (95% CI -0.01 to +0.09). CONCLUSIONS: The severity of large vessel macrovascular disease, as assessed by ABPI, is not dependent on disease subtype. Anticentromere antibody may be weakly associated with a reduction in ABPI.

Adult↗
PubMed1986

An evaluation of fetal weight prediction using a simple equation containing the fetal femur length.

The accuracy of sonographic fetal weight estimation based on five published regression equations and two new equations generated from data at the authors' institution was evaluated on 41 small-for-gestational age (SGA) fetuses and 57 appropriate-for-gestational age (AGA) fetuses. Equations which contained the fetal femur length (FL) in addition to the biparietal diameter (BPD) and abdominal circumference (AC) yielded lower systematic and random errors in the SGA group but not in the AGA group. These findings support the contention that consideration of the FL is important in sonographic estimation of fetal weight in the growth-retarded fetus as head and limb growth may be affected to different degrees in different fetuses. A new equation, where birthweight in grams = 1.4 X (BPD(cm) X AC(cm) X FL(cm)) - 200, was developed which had a standard deviation of 98 g/kg in SGA fetuses and 68 g/kg in AGA fetuses. This equation yielded significantly lower random errors in the SGA but not in the AGA fetuses when compared with another linear equation without the FL. The new model is simple and practical to use, which makes it a viable alternative to more elaborate models containing three parameters.

Abdomen↗