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Biomedical subjects

M C Woussen-Colle

Publications and source records attributed to M C Woussen-Colle.

At least 55 records · Page 3Linked to original sources
PubMed1976

Effect of jejunal resection on the gastric acid secretory response to pentagastrin, histamine and feeding in dogs.

In dogs with gastric fistulas and denervated pouches from the oxyntic area, the acid secretory responses to a meal and to graded doses of histamine and pentagastrin were measured before and after resection of the upper half of the small bowel. Intestinal resection caused a small but significant increase in submaximal and maximal response from the pouch to histamine and pentagastrin without modification of the ED50. This effect was not observed in the innervated stomach. The response from the pouch to feeding was markedly increased and prolonged. These data indicate that both an increase in stimulation and an increase of the response to this stimulation are responsible for the increased acid secretion observed in the pouch when resected dogs were fed. These effects could be explained by the withdrawal of inhibitors of intestinal origin.

Animals↗
PubMed1976

[Effect of cortisone acetate on acid secretion induced by histamine, pentagastrin, gastrin and food in dogs].

The effects of long term treatment with cortisone on the gastric secretion induced by histamine, pentagastrin, porcine gastrin and a meal have been investigated in four dogs with both gastric fistula and Heidenhain pouch. Cortisone increased the postcibal acid output and the observed maximal acid response from the pouch to all three exogenous stimuli. The ED 50'S remained unchanged. The same effects although less marked were observed in the innervated stomach. These data indicate that the increased acid secretion observed after long term treatment with cortisone is largely due to an increased secretory capacity of the gastric mucosa. This latter could result from an increase in the number of secretory units or to partial removal of a non competitive inhibitor of gastric secretion.

Animals↗
PubMed1976

Effect of feeding on catabolism and activity of exogenous gastrin in dogs.

The effect of meal upon the catabolism and activity of exogenous gastrin was tested in 4 antrectomized and 4 non antrectomized dogs with Heidenhain pouches. In both antrectomized and non antrectomized dogs infused with exogenous gastrin, the meal decreased the serum gastrin level. This decrease amounted to about 20%, 60 minutes after feeding and the gastrinemia then returned gradually to control levels. In non antrectomized dogs, infusion of a near maximal dose of gastrin increased the acid response to the meal to a level above the maximal histamine acid output. Exogenous gastrin also increased the acid response to a meal in antrectomized dogs. These data indicate: 1) That feeding increases the metabolic clearance rate of exogenous gastrin. This effect could be at least partly related to changes in the intestinal blood flow. 2) That, after feeding, one or several hormones capable of stimulating the acid secretion but unrelated to gastrin are probably released. These hormones could be of major importance in the response of denervated pouches to feeding.

Animals↗
PubMed1976

Failure to pentagastrin administration to restore postprandial acid secretion from Heidenhain pouches after antrectomy in dogs.

In four dogs with Heidenhain pouche, acid outputs from the pouch were measured in response to feeding boiled liver with or without simultaneous administration of pentagastrin. Antrectomy was performed and the experiments were repeated. Antrectomy decreased the acid response to feeding by 90 percent. The preantrectomy response was restored by infusing pentagastrin but near maximal doses were needed and the maximal response to feeding plus pentagastrin could not be restored. These results indicate that the decrease of the acid secretory response to feeding from Heidenhain pouches after antrectomy cannot be explained fully through suppression of endogenous gastrin release. Antrectomy probably interferes with the intestinal phase of gastric secretion.

Animals↗
PubMedDate not supplied

[Physiological control and pharmacological inhibition of digestive secretions].

The pharmacological treatment of alimentary tract fistulas was for a long time limited to the use of atropine and related substances. More recently H2 blockers, pirenzepine, omeprazole and loperamide have been used. It is likely that in the coming years specific and long acting derivatives of somatostatin and enkephalins inhibiting digestive secretions will be synthetized.

Bile↗