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Biomedical subjects

M C de Krom

Publications and source records attributed to M C de Krom.

26 records · Page 2Linked to original sources
PubMed1990

Efficacy of provocative tests for diagnosis of carpal tunnel syndrome.

The validity of twelve provocative tests for carpal tunnel syndrome (CTS) in a random sample of 504 people from the general population was assessed. 50 woke up at night due to paraesthesiae (with or without numbness or pain) in the fingers innervated by the median nerve (CTS symptoms) in 93 hands. CTS was neurophysiologically confirmed in 28 subjects (44 hands)--a prior probability for CTS of 47%. All clinical diagnostic tests had a low validity. Posterior probability of CTS ranged from 35 to 70% for positive test results and from 41 to 62% for negative test results. A combination of three tests with relatively high validity (paresis of abductor pollicis brevis muscle, hyperpathia, and flick sign) did not significantly change the probability of CTS. Patients with CTS symptoms should be referred directly for neurophysiological examination.

Adult↗
PubMed1990

Risk factors for carpal tunnel syndrome.

Between September 1983 and July 1985, a case-control study was performed of carpal tunnel syndrome risk factors in the general population of Maastricht, The Netherlands, and some surrounding villages. Twenty-eight of the 501 participants were found to suffer from carpal tunnel syndrome. These 28 were added to a series of 128 consecutive carpal tunnel syndrome patients from the same area. The 156 (131 women and 25 men) subjects in whom carpal tunnel syndrome had been diagnosed on the basis of clinical history and neurophysiologic testing were compared with the remaining 473 (310 women and 163 men) subjects. After adjustment for age and sex, the following carpal tunnel syndrome risk factors could be identified: activities with a flexed wrist or with an extended wrist (exposure-related increased risk), hysterectomy without oophorectomy, last menstrual period in menopausal women 6-12 months ago, height, weight, Quetelet index, slimming courses, and in men, varicosis. Associations between carpal tunnel syndrome and the use of oral contraceptives, age at menopause, diabetes, thyroid dysfunction, rheumatism, typing, and pinch grasp could not be demonstrated.

Adult↗
PubMed1989

Schilder's diffuse sclerosis: case study with three years' follow-up and neuro-imaging.

Schilder's diffuse myelinoclastic sclerosis, a rarely described disease in childhood, was diagnosed in the case of a 6-year-old girl with subacute cerebral disease. CT-scanning showed asymmetric rim-enhancing lesions within the cerebral white matter. Spontaneous clinical improvement occurred prior to corticosteroid treatment. Follow-up by CT and MRI for three years showed the development of stable amyelinic lesions. Improvement in motor control and in electrophysiological recordings contrasted with an arrest in neuropsychological development. The differential diagnosis and the prognostic implications of this disease are stressed.

Child↗
PubMed1983

Two Dutch siblings with congenital muscular dystrophy (Fukuyama type).

Two Dutch siblings are described suffering from muscular weakness, hypotonia, severe joint contractures, mental retardation and epileptic fits. E.M.G. showed a characteristic myopathic pattern. Muscle biopsy revealed changes consistent with congenital muscular dystrophy. On CT marked hypodensities of the cerebral white matter were noticed. These findings are consistent with congenital muscular dystrophy of the Fukuyama type, a peculiar form of congenital muscular dystrophy, extremely rare outside Japan.

Adult↗