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Biomedical subjects

M COUPERUS

Publications and source records attributed to M COUPERUS.

5 recordsLinked to original sources
PubMed1954

Ammoidin (xanthotoxin) in the treatment of vitiligo.

Eighteen patients with vitiligo were treated with two crystalline substances, xanthotoxin (Ammoidin) and imperatorin (Ammidin) from the plant Ammi majus. Four patients improved more than 50 per cent. One had complete cure, but depigmentation recurred after a few months. Six patients had moderate improvement (less than 50 per cent), three had slight repigmentation, and in five cases there was no improvement. These results are similar to those reported by other investigators.Pronounced local inflammatory reactions are to be expected after exposure to ultraviolet light in nearly all patients treated with xanthotoxin. In one case prolonged sensitivity to sunlight, manifest by vesiculating dermatitis, occurred.

Adult↗
PubMed1953

Early diagnosis of malignant melanoma of the skin.

About five per cent of all malignant lesions of the skin are malignant melanomas. The poor prognosis associated with this malignant lesion emphasizes the importance of early diagnosis. A large proportion of malignant melanomas arise in preexisting lesions such as junction nevi, precancerous melanoses and, much more rarely, blue nevi. Early malignant changes in these precursor lesions include increasing pigmentation, enlargement, thickening, crusting, bleeding, ulceration, tumor formation, and development of satellite lesions. Many pigmented, and some non-pigmented, lesions of the skin must be differentiated from malignant melanoma. Since even with radical surgical treatment the prognosis of malignant melanoma is poor, junction nevi which are subject to continual trauma or have signs of probable malignant degeneration should be prophylactically excised.

Early Diagnosis↗