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Biomedical subjects

M Cadot

Publications and source records attributed to M Cadot.

At least 19 recordsLinked to original sources
PubMed1996

Localized epidermolysis bullosa acquisita of the esophagus in a patient with Crohn's disease.

Epidermolysis bullosa acquisita is a rare autoimmune subepidermal bullous disease that affects both the skin and mucosae and is frequently associated with Crohn's disease. We report the case of a 27-yr-old man with Crohn's disease who presented with localized epidermolysis bullosa acquisita of the esophagus, without any other mucosal or cutaneous lesions. The patient was successfully treated with sulfasalazine.

Adult↗
PubMed1993

The dark choroid in systemic argyrosis.

Argyrosis is a cutaneous discoloration caused by silver. Ocular involvement, including conjunctival and corneal discoloration, has been previously reported. To our knowledge, a retinal involvement was never reported and no data is available about fluorescein angiography patterns of patients with argyrosis. Fluorescein angiography was performed in six consecutive patients with iatrogenic systemic argyrosis. A dark choroid was observed in each case. Red light monochromatic pictures disclosed a leopard spot pattern on the fundus, which was more clearly revealed in one patient by infrared light pictures. These findings suggest that the silver deposit in Bruch's membrane may be responsible for the obscuration of choroidal fluorescence during dye transit and for the visualization of choriocapillary units in pictures using long-wavelength light. The dark choroid is not only present in central retinal dystrophies, but may be observed in other conditions, such as systemic argyrosis.

Adult↗
PubMed1989

[Rothmund's syndrome].

Rothmund's syndrome was observed in a 9 year old boy. Parental consanguinity was present, but no siblings were affected. He presented with rapidly progressive bilateral cataracts. Visual recuperation was excellent after "in the bag" phakoemulsification and intercapsular implantation. There were no other ocular anomalies. Extensive erythematous skin changes appeared when the boy was 3 months old and, at the time of presentation, he had poïkiloderma predominantly in those areas exposed to light (face and hands). There were no associated anomalies of the nails or hair, no endocrine disorder nor other malformations. A brief review of this syndrome is presented and treatment of these cataracts discussed.

Cataract↗
PubMed1989

[Parry-Romberg progressive facial hemiatrophy and localized scleroderma. Nosologic and pathogenic problems].

A case of a 65-year-old caucasian woman with progressive hemifacial atrophy (Parry-Romberg syndrome) is reported. The atrophy had begun ten years before. At time of presentation, she was suffering from facial pain and diplopia. She presented with severe enophthalmos associated with eyelid atrophy, loss of cilia and mild blepharoptosis. There was a patch of alopecia and atropic areas of skin, recognised as scleroderma "en coup de sabre". Ophthalmic examination showed miosis. Horner's syndrome and ocular motility disturbance. Biomicroscopic examination of anterior and posterior segments was normal; there was no heterochromia and no disc atrophy. Aesthetic surgical treatment was proposed. The etiology of hemifacial atrophy remains controversial, and its relations with scleroderma and autonomic nervous system disorders are discussed.

Aged↗
PubMed1984

[Skin manifestations of sarcoidosis. Review of the literature and 53 personal cases].

The authors review the literature and 53 personal cases, and describe the very variable appearances of the skin lesions in sarcoidosis: these may be divided into two main groups: non-specific "vasculitis" mainly represented by acute lesions of the erythema nodosum type, and specific polymorphic lesions often difficult to diagnose clinically and requiring skin biopsy. As in previous reports, the personal cases bring out a number of special features: silicotic granulomatous sarcoid like lesions may be observed in authentic cases of sarcoidosis; lesions identical to those described in systemic sarcoidosis may appear in isolation without other localisations. Is this cutaneous sarcoid? or sarcoid-like granulomata of unknown origin? The treatment of sarcoid skin lesions is described briefly.

Adrenal Cortex Hormones↗
PubMed1983

Ketone bodies in cold-acclimated rats.

Acclimation temperature (28 or 5 degrees C) modifies acetoacetate (AA) and beta-hydroxybutyrate (BOH) levels in blood and liver. In the fed state AA and BOH levels were increased in blood and liver of 5 degrees C adapted rats. In the fasting state (24 or 48 hr) an antiketotic action of cold acclimation was observed. It was found to be more pronounced with high fat diet. These effects were more marked in the blood than in the liver. The variations in ketonemia are discussed with relation to the role of liver in cold adapted rats.

3-Hydroxybutyric Acid↗
PubMed1981

Cold-induced developmental changes in fat cell size and number in brown adipose tissue of the rat.

Seven-week-old Long-Evans rats were acclimated to a constant temperature of either 28 degrees C (control group) or 5 degrees C (cold-acclimated group). Cold acclimation induced a 70% increase in the interscapular brown adipose tissue (IBAT) relative mass, a 35% increase in DNA content, and a 44% decrease in triglyceride (TG) content, which resulted in a 51% decrease of the TG/DNA ratio. A procedure is described by which brown fat cells were isolated, with a yield of 21% from the IBAT of the control group and of 38% in the cold-acclimated group. In both groups, the brown fat cells accounted for 35-37% of the total cells in the tissue. Cold acclimation induced decreases in the mean fat cell diameter (about 20%), the mean fat cell TG content (50%), and the fat cell TG/DNA ratio (50%). The total number of IBAT fat cells was significantly increased in cold-acclimated rats. It is concluded that cold acclimation involves a hyperplasia of the IBAT, associated with a decrease of fat cell size without any alteration of the fat cell-to-nonfat cell ratio.

Acclimatization↗
PubMed1979

Cellularity and composition of epididymal adipose tissue from cold-acclimatized rats.

Cold acclimatization induces morphological and compositional modifications of rat epididymal adipose tissue: a decrease in fat cell size, an increase of fat cell number per g of tissue, but no significant increase in total fat cell number in the tissue; finally, an increase in protein content and a decrease in triglyceride content.

Acclimatization↗
PubMed1979

The lipid composition of plasma membrane and mitochondrial fractions from epididymal adipocytes of cold-acclimated rats.

1. The effects of cold acclimation (5 degrees C) on the lipid composition of plasma membrane and mitochondrial fractions from epididymal adipocytes of rats were studied. 2. The adipocyte plasma membrane fraction of the cold-acclimated rats had lower lipid, phospholipid and cholesterol to protein weight ratios, a lower cholesterol to sphingomyelin molar ratio, and a higher linoleic acid content in the phospholipids than controls. 3. The mitochondrial fraction of the cold-acclimated rat adipocyte had lower ratios of cholesterol to protein (weight), to phospholipid and to cardiolipin (molar), and less sphingomyelin content than did controls. 4. These data, discussed in terms of alterations in physical and biochemical properties, indicate cold-induced changes at the membrane level in rat epididymal adipocytes.

Acclimatization↗
PubMed1978

[Successive bilateral adrenal phaeochromocytoma. One case (author's transl)].

A patient underwent surgery for the first time at the age of ten years for a right-sided adrenal phaeochromocytoma. She underwent a second operation at the age of 27 years, for a contro-lateral localisation. Phaeochromocytomas are rare in the child. They are frequently bilateral, multiple and situated extra-adrenally. They fall within the context of Sipple's syndrome more rarely than in the adult. Treatment of these bilateral forms requires bilateral adrenalectomy in one or two stages, followed by substitute hormone therapy.

Adolescent↗