[Relationships between the hemodynamic and metabolic aspects of patients during shock. Significance of the average-body intracellular pH].
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Gastrointestinal Hemorrhage↗
Biomedical subjects
M Cagossi
Publications and source records attributed to M Cagossi.
[Hemodynamic evaluation of chronic uremic patients undergoing periodical hemodialytic treatment].
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Chronic Disease↗
Gastric cancer in the elderly.
Nowadays an increased number of elderly patients undergo surgery for gastric cancer. The old age by itself does not seem to represent a prohibitive risk factor anymore. Two groups of patients operated on of gastric cancer at our surgical unit (Group A = 378 patients younger or as old as 65 years and Group B = 330 patients older than 65 year) were compared. There were not statistically significant differences between the two groups in terms of number of performed radical exereses (57.7% vs. 42.3% respectively), kind of resective operation (total gastrectomy or subtotal gastrectomy) and extent of lymphadenectomy (D2-D3 type: 64.7% vs 63.8% respectively). The location of tumor, the distribution by stage and the long term survival of radically resected cases were not statistically different in the two groups of patients. Five-year survival after radical resection was 56.8% and 54.0% respectively. We conclude that elderly patients in good clinical conditions affected by gastric cancer should undergo radical resection with lymphadenectomy such extensive as D2-D3 type.
Age Factors↗
Twenty-four-hour intragastric pH-metry: evidence of nightly gastric alkalinization in subjects with and without active duodenal ulcer.
Continuous 24-hour gastric pH monitoring was performed in 68 subjects to evaluate the spontaneous nightly alkalinization phenomenon (SNA). Two groups of patients were compared: the first (group A) was composed of 27 subjects with active duodenal ulcer disease; group B included 12 healthy volunteers and 29 patients with gastroesophageal reflux. Patients with duodenal disease had an alkalinization of 196.2 +/- 97.9 seconds in duration, while healthy subjects and even gastroesophageal refluxers exhibit a SNA lasting 5269 +/- 748.3 seconds (t = 6.72; p < 0.001). The absence of SNA was used as a predictive test of duodenal ulcer disease and its discriminating ability was evaluated. The evidence of this phenomenon was able to exclude the disease in 90% of group B subjects (negative predictive value) while its absence suggested correctly the presence of duodenal disease in 82% of patients (positive predictive value). The lack of SNA in duodenal ulcer patients is so frequent that its absence might be a diagnostic sign of the peptic disease.
Adult↗
Twenty-four-hour intragastric pH-metry: H2-receptor antagonist restoration of nightly gastric spontaneous alkalinization in duodenal ulcer healing.
Continuous 24-hour intragastric pH monitoring allows the evaluation of spontaneous late night gastric alkalinization phenomenon (SNA). This nocturnal increase of intragastric pH is strongly evident in healthy volunteers but is insignificant in patients with active duodenal ulcer. Gastric acidity was monitored by 24-hour continuous pH-metry in nine patients with active duodenal ulcer disease before and after two weeks of therapy with ranitidine. A twice daily dose of the drug (150 mg at 08.00 h and 150 mg at 20.00 h) was orally administered to each subject. Before treatment the ulcer patients did not show the SNA phenomenon, but the therapy led it to reappear. Ranitidine significantly reduced the time during which the gastric acidity was lower than 4 pH units; moreover the drug was effective on the ulcer healing during a period as brief as two weeks of therapy. At least a complete healing of the duodenal ulcer could be seen in patients whose overall gastric acidity time was reduced almost to the 40% of the pre-treatment value, meal times excluded from the pH-metric calculation.
Adult↗
[The mental variable in oncological research. Elaboration of the medico-psychologic literature on problems of cancerogenesis].
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Central Nervous System↗
Pulmonary vascular resistance changes in experimental hemorrhagic shock.
Hemorrhagic shock was experimentally induced in 40 mongrel dogs, and the resulting pulmonary vascular resistances studied. A mechanical test with closure of the left branch of the pulmonary artery and two pharmacological tests with isoproterenol (isuprel) and cyclic adenosine-monophosphate (cAMP) were performed. The results suggest that there is a block in the beta-control during prolonged shock, and that beta-control is restored by cAMP.
Animals↗
The nightly spontaneous alkalinization of the stomach.
Authors evaluated eighty-four 24-hour intragastric pH recordings of 73 subjects in different pathophysiologic conditions. Among them there were 12 healthy subjects, 27 duodenal ulcer patients, 10 of whom were examined both before and after treatment with H2 receptor antagonists, 18 gastro-esophageal refluxers and 16 other patients who complained of dyspepsia of various origins. Authors observed a spontaneous nocturnal alkalinization phenomenon of the stomach (SNA) which began in the latter part of the night; its onset was strongly related with sleeping and interrupted by waking up. This phenomenon was absent in duodenal ulcer patients but could be restored by treatment with anti-H2 drugs. The authors, moreover, gave evidences of a relation between SNA and the vagal integrity and modulation of the gastric secretions.
Circadian Rhythm↗