[Prenatal diagnosis of thalassemia: experience in Piedmont].
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Biomedical subjects
Publications and source records attributed to M Campogrande.
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CB04 monoclonal antibody which reacts with an epitope of a surface molecule expressed on human monocytes has been elicited using peripheral blood lymphocytes as immunizer. The characterization of the monoclonal antibody examined at the phenotypic, molecular, and functional levels indicates that the CB04 antibody defines a structure present on monocytes, tissue macrophages, B cells, polymorphonucleates, and erythrocytes. The molecular weight (220 kD), the tissue distribution in health and disease conditions, and the involvement in relevant biological processes indicate that the CB04 structure is the receptor for the C3b fragment of the complement. The binding of the antibody to the cell surface induces inhibition of the C3bi receptorial function.
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Fetal biparietal diameter, transverse thoracic diameter abdominal circumference and area were measured by ultrasound in 50 pregnant women at term not more than 48 hours before delivery. Multiple regressions correlating birth weight with all these parameters were obtained and estimated birth weight (calculated from the regressions) was compared with the actual birth weight. The error in prediction was under 200 g in 56%, under 300 g in 66% and under 400 g in 84% of patients when all fetal measurements were used. It was under 200 g in 48%, under 300 g in 66% and under 400 g in 74% when only the abdominal area was used; and it was under 200 g in 46%, under 300 g in 56% and under 400 g in 82% when the abdominal circumference alone was used. Biparietal diameter and transverse thoracic diameter alone were not useful in predicting birth weight.
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