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Biomedical subjects

M Caputo

Publications and source records attributed to M Caputo.

At least 91 records · Page 5Linked to original sources
PubMed1982

[Value of vectorcardiography in the diagnosis of postero-septal infarct].

Posteroinferior infarction often complicated by the contemporaneous antero-septal necrosis due to anterior descending coronary artery critical stenosis. To confirm the value of VCG in the diagnosis of these two necrosis as regards ECG, the Authors have studied with echocardiogram, 19 patients with postero infarction, with or without inferior necrosis. The results were: frequent association of antero-septal infarction in postero-inferior necrosis; morphological and chronological VCG criteria in the diagnosis of postero-septal infarct; VCG use as bloodless method, to distinguish among the subjects with postero necrosis, the patients who must be subjected coronary angiography.

Coronary Disease↗
PubMed1982

[Comparison between clinical and electrophysiological data before and after definitive pacemaker implantation for the sick sinus syndrome].

Personal observations of 22 patients with permanent inhibited ventricular PM for SSS during the period July 1976-February 1979 and re-examined with electrophysiological study after a follow-up made for an average period 25,5 months (14 to 49 months), after PM inhibition from the outside are presented. Patients were divided into 2 groups (group 1 with bradycardia and group 2 with brady-tachy arrhythmia). In spite of relative exiguity and uniformity of this casuistry, the conclusion is drawn that CSNRT and atropine test were more significant than SACT, in particular in forms with less pathological electrophysiological parameters.

Aged↗
PubMed1980

[Value of the Di Maria leads in the electrocardiographic diagnosis of posterior myocardial infarct].

Authors retain, on the basis of their experiences, that right chest leads proposed by Di Maria for the infer-posterior and postero-basic myocardium wall study can overall be useful in those cases which had posterior myocardial infarction and where standard leads did not show variations or showed untrustworthy variations. Therefore Authors also supported by vectorcardiographic findings, recommend the routine use of Di Maria leads.

Electrocardiography↗
PubMed1980

[Myocardial infarct in the aged subject. Its prognostic significance].

After our study on 72 patients over 70 years, admitted to a coronary care unit since january 1975 to december 1977 and compared with a control group of 119 patients under 70 years, we found that the hospital mortality rate was of 32% for the geriatric subjects and of 9,3% for the control group. Women over 70 years had a higher mortality: 14 (over 72) to 3 (over 119). The AMI was the more diffused, with a death percent rate higher (40%) than infarctions elsewhere localized. Between death causes, cardiogenic shock often occurred in AMI (69,5%). From a follow-up carried out in january 1978 it resulted that 57% of the 49 geriatric dismissed patients 28 survived and 15 (30,5%) died.

Age Factors↗
PubMed1980

[Methodological problems concerning the assay of sex hormone binding globulin with DEAE-cellulose].

Since 1966 a carrier protein for the sex hormones, testosterone and estradiol, has been identified. Mickelson and Petra measured SHBG concentration by adsorption method in 1974. The SHBG contained in serum is incubated with DHT-3H and adsorbed to a cellulose filter. In this study we have reviewed this method. The method showed good reproducibility with a coefficient of variation of 8,1% for low concentration of SHBG and 11,6% for high concentration. No effects of serum dilution was observed. Normal values, expressed as micrograms DHT bound in 100 ml serum, resulted: females, 0,88 +/- 0,08 (ES); males, 0,58 +/- 0,04; pregnancy, 2,94 +/- 0,4. The mean value for males was significantly lower than the mean value for normal females (P < 0,005); pregnancy had a mean value statistically different from the normal females (P < 0,001).

DEAE-Cellulose↗
PubMed1980

Chemotherapeutic activity and histopathologic feature of BCNU + 5-FU effect on Lewis lung carcinoma.

In this study we investigated the effects of BCNU + 5-FU on the intramuscularly implanted Lewis lung carcinoma and on its spontaneous lung metastases. Chemotherapeutic agents were given i. v. either alone and in combination seven days after transplantation of 2.5 x 10(5) viable tumor cells, when the average weight of the primary tumor was 500 mg. The analysis of the following parameters: T/C, T--C, of %-metastases reduction, indicates that the simultaneous administration of BCNU + + 5-FU induces a more relevant response on the Lewis lung carcinoma than single drug therapy, especially evident at level of lung metastases.

Animals↗
PubMed1979

In vitro and in vivo selection of two Lewis lung carcinoma cell lines.

Two tumor cell lines adapted to grow in vitro were originated from an explant of lung metastases of Lewis lung carcinoma. These lines differ in their malignancy when reinoculated into syngeneic animals; nevertheless, they do not show any difference for their in vitro clonogenic ability. From these lines 2 in vivo sublines of 3LL carcinoma were developed. The TD50 of the 2 in vivo sublines are different, and both the values obtained are lower than that of the original line. These results are interpreted as a selection of more malignant tumor cell lines.

Animals↗
PubMed1979

Cyclophosphamide and iphosphamide against Lewis lung carcinoma: evaluation of toxic and therapeutic effects.

In the present report, investigations have been carried out to evaluate toxic and therapeutic effects of cyclophosphamide vs its isomer iphosphamide. Cytostatic action of the 2 drugs was assayed on the murine Lewis lung carcinoma (3LL). It has been observed that iphosphamide is less toxic as compared to cyclophosphamide (LD50 IP LD50 CP = 1.5); on the other hand, to reach the same therapeutic effectiveness on 3LL, an iphosphamide dose 1.6 - 2 times higher than that of its parent compound is necessary.

Animals↗