Peripheral polyneuropathy during treatment with alpha-2 interferon.
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Humans↗
Biomedical subjects
M Caramia
Publications and source records attributed to M Caramia.
[Usefulness of an amoxicillin/clavulanic-acid combination in respiratory tract infection: bacterial resistance and antibiotic therapy].
The continual use of antibiotics and the defence works of microorganisms have induced less activity of many antibiotics once particularly effective for their excellent therapeutic index. The association of clavulanic acid with amoxicillin, the latter a long time used for its excellent therapeutic index particularly in respiratory tract infections, has restored and some ways potentiated the once activity of the latter.
Amoxicillin↗
[2 cases of mitochondrial encephalomyopathy].
Two cases of mitochondrial myopathy are described. An electrophysiological study was also accomplished to investigate the concomitant involvement of the central nervous system (CNS), by means of evoked potentials (EP). The EPs in fact can reveal minimal signs of CNS lesions also when muscular damage is the only clinical evidence.
Adult↗
Non-clinical tests for the diagnosis of multiple sclerosis.
Liquoral, Neurophysiological and Nuclear Imaging data were investigated in 29 patients suffering from Definite (11 cases), Probable (11 cases) and Possible (7 cases) Multiple Sclerosis (MS). The most sensitive tests were: Visual Evoked Potentials (VEPs), altered in 75% of patients, Motor Evoked Potentials (MEPs), abnormal in 75%, Nuclear Magnetic Resonance Imaging (MRI) in 72.4%. Somatosensory Evoked Potentials (SEPs) were altered in 69.2% in PN-SEPs and in 53.6% in MN-SEPs, whilst Brainstem Evoked Potentials (BAEPs) were altered in 30.8% of cases. The results suggest that patients with suspected forms of MS should be submitted, as routine diagnostic protocol, to a battery of EPs, including as a first choice VEPs, MEPs and PN-SEPs. MRI should be performed to confirm a diagnosis not supported by EP data, or for a comprehensive localization of the demyelinating plaques.
Adolescent↗
The treatment of severe forms of myasthenia gravis.
In this study we introduced and tested the clinical efficacy of a combined treatment based on the association of plasma exchange (PE) with high daily doses of prednisone in 18 patients with severe forms of myasthenia gravis (MG). A myasthenic score based on strength and resistance was evaluated in each patient in basal condition and during the treatment. The study design included 5 sessions of PE, performed within a period of 15 days, 1 session every 3 days, associated with administration of oral prednisone (1 mg/kg of body weight), which began at the same time as the first session and was continued following a daily schedule for at least three months. A significant improvement was obtained from the start of the therapy, with a reduction of the myasthenic score from 26.56 to 11.44 by day 10 and with further reduction after PE interruption. An early improvement, recorded within 24-48 hours of the beginning of the study design, was observed in 11/18. The administration of steroid therapy was never followed by a worsening of myasthenic symptoms (as reported when it is administered in the absence of concomitant PE). No recurrence of symptoms was reported after 29 months' follow-up. This type of therapeutic association was generally well tolerated and no unwanted side effects were observed. According to our results we can conclude that medium-high doses of oral prednisone in simultaneous association with PE lead to a successful control of severe forms of MG and may be considered a valid therapeutic strategy.
Adolescent↗